There is always a football match nearby!
Matchdaylist is the easiest way finding football matches in top and lower leagues.
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| home | away | date | time |
| Varzim | Farense | 12-01-2022 | 16:30 |
| Atalanta | Venezia | 12-01-2022 | 17:30 |
| Barcelona | Real Madrid | 12-01-2022 | 20:00 |
| West Ham | Norwich | 12-01-2022 | 20:45 |
| Tottenham | Chelsea | 12-01-2022 | 20:45 |
| Crewe | Charlton | 12-01-2022 | 20:45 |
| Barnsley | Stoke City | 12-01-2022 | 20:45 |
| Inter | Juventus | 12-01-2022 | 21:00 |
| Napoli | Fiorentina | 13-01-2022 | 18:00 |
| Bourg-en-bresse 01 | Bastia-Borgo | 13-01-2022 | 19:00 |
| Famalicao | Belenenses | 13-01-2022 | 19:00 |
| Atletico Madrid | Athletic Club | 13-01-2022 | 20:00 |
| Benevento | Monza | 13-01-2022 | 20:30 |
| Lecce | Vicenza Virtus | 13-01-2022 | 20:30 |
| Liverpool | Arsenal | 13-01-2022 | 20:45 |
| AC Milan | Genoa | 13-01-2022 | 21:00 |
| Besiktas | Gazi?ehir Gaziantep | 14-01-2022 | 18:00 |
| Menemen Belediyespor | Band?rmaspor | 14-01-2022 | 18:00 |
| Yeni Malatyaspor | Goztepe | 14-01-2022 | 18:00 |
| Hansa Rostock | Hannover 96 | 14-01-2022 | 18:30 |
| Dynamo Dresden | Hamburger SV | 14-01-2022 | 18:30 |
| Boulogne | RED Star FC 93 | 14-01-2022 | 19:00 |
| Chambly Thelle FC | Stade Briochin | 14-01-2022 | 19:00 |
| Creteil | Le Mans | 14-01-2022 | 19:00 |
| Sedan | Villefranche | 14-01-2022 | 19:00 |
| Concarneau | Orleans | 14-01-2022 | 19:00 |
| Chateauroux | Avranches | 14-01-2022 | 19:00 |
| Havelse | MSV Duisburg | 14-01-2022 | 19:00 |
| Excelsior | De Graafschap | 14-01-2022 | 20:00 |
| Dordrecht | Jong AZ | 14-01-2022 | 20:00 |
| NAC Breda | FC Volendam | 14-01-2022 | 20:00 |
| Telstar | MVV | 14-01-2022 | 20:00 |
| Almere City FC | Roda | 14-01-2022 | 20:00 |
| FC Eindhoven | Jong Utrecht | 14-01-2022 | 20:00 |
| VVV Venlo | Jong PSV | 14-01-2022 | 20:00 |
| PEC Zwolle | Willem II | 14-01-2022 | 20:00 |
| Emmen | Helmond Sport | 14-01-2022 | 20:00 |
| Borussia Dortmund | SC Freiburg | 14-01-2022 | 20:30 |
| Ternana | Ascoli | 14-01-2022 | 20:30 |
| Penybont | Barry Town | 14-01-2022 | 20:45 |
| Newtown AFC | Cardiff MET | 14-01-2022 | 20:45 |
| The New Saints | Cefn Druids AFC | 14-01-2022 | 20:45 |
| Gent | Kortrijk | 14-01-2022 | 20:45 |
| Flint Town United | GAP Connah S Quay FC | 14-01-2022 | 20:45 |
| Bala Town | Caernarfon Town | 14-01-2022 | 20:45 |
| Newry City AFC | H&W Welders | 14-01-2022 | 20:45 |
| Newry City AFC | H&W Welders | 14-01-2022 | 20:45 |
| Partick | Kilmarnock | 14-01-2022 | 20:45 |
| Newry City AFC | H&W Welders | 14-01-2022 | 20:45 |
| Newry City AFC | H&W Welders | 14-01-2022 | 20:45 |
| Newry City AFC | H&W Welders | 14-01-2022 | 20:45 |
| Brighton | Crystal Palace | 14-01-2022 | 21:00 |
| Aberystwyth Town | Haverfordwest County AFC | 14-01-2022 | 21:00 |
| Nice | Nantes | 14-01-2022 | 21:00 |
| Denizlispor | Manisa BBSK | 15-01-2022 | 11:30 |
| Adana Demirspor | Kayserispor | 15-01-2022 | 11:30 |
| Casa Pia | Academico Viseu | 15-01-2022 | 12:00 |
| Luton | Bournemouth | 15-01-2022 | 13:30 |
| Newport County | Harrogate Town | 15-01-2022 | 13:30 |
| Cardiff | Blackburn | 15-01-2022 | 13:30 |
| Manchester City | Chelsea | 15-01-2022 | 13:30 |
| Werder Bremen | Fortuna Dusseldorf | 15-01-2022 | 13:30 |
| FC St. Pauli | Erzgebirge AUE | 15-01-2022 | 13:30 |
| FC Nurnberg | SC Paderborn 07 | 15-01-2022 | 13:30 |
| VfL Osnabruck | FC Saarbrucken | 15-01-2022 | 14:00 |
| FC Kaiserslautern | SV Meppen | 15-01-2022 | 14:00 |
| Freiburg II | FC Magdeburg | 15-01-2022 | 14:00 |
| Hallescher FC | Türkgücü-Ataspor | 15-01-2022 | 14:00 |
| FSV Zwickau | FC Viktoria Koln | 15-01-2022 | 14:00 |
| TSV 1860 Munich | SV Wehen | 15-01-2022 | 14:00 |
| Cremonese | como | 15-01-2022 | 14:00 |
| Parma | Crotone | 15-01-2022 | 14:00 |
| Cittadella | Nuova Cosenza | 15-01-2022 | 14:00 |
| Reggina | Brescia | 15-01-2022 | 14:00 |
| Sivasspor | Trabzonspor | 15-01-2022 | 14:00 |
| Quick Boys | HHC | 15-01-2022 | 15:00 |
| Rijnsburgse Boys | Volendam II | 15-01-2022 | 15:00 |
| Kozakken Boys | Ijsselmeervogels | 15-01-2022 | 15:00 |
| Spakenburg | TEC | 15-01-2022 | 15:00 |
| Queen's University | Knockbreda | 15-01-2022 | 15:00 |
| Sampdoria | Torino | 15-01-2022 | 15:00 |
| Ajaccio | Auxerre | 15-01-2022 | 15:00 |
| Guilsfield | Holywell | 15-01-2022 | 15:30 |
| Sparta Rotterdam II | ASWH | 15-01-2022 | 15:30 |
| FC Koln | Bayern Munich | 15-01-2022 | 15:30 |
| FSV Mainz 05 | VfL BOCHUM | 15-01-2022 | 15:30 |
| VfB Stuttgart | RB Leipzig | 15-01-2022 | 15:30 |
| VfL Wolfsburg | Hertha Berlin | 15-01-2022 | 15:30 |
| Union Berlin | 1899 Hoffenheim | 15-01-2022 | 15:30 |
| Millwall | Nottingham Forest | 15-01-2022 | 16:00 |
| Fulham | Bristol City | 15-01-2022 | 16:00 |
| QPR | West Brom | 15-01-2022 | 16:00 |
| AFC Wimbledon | Morecambe | 15-01-2022 | 16:00 |
| Barnet | Chesterfield | 15-01-2022 | 16:00 |
| Wealdstone | Dover | 15-01-2022 | 16:00 |
| Stevenage | Sutton Utd | 15-01-2022 | 16:00 |
| Wycombe | Oxford United | 15-01-2022 | 16:00 |
| Gillingham | Burton Albion | 15-01-2022 | 16:00 |
| Colchester | Barrow | 15-01-2022 | 16:00 |
| Newcastle | Watford | 15-01-2022 | 16:00 |
| Northampton | Forest Green | 15-01-2022 | 16:00 |
| Portsmouth | Milton Keynes Dons | 15-01-2022 | 16:00 |
| Peterborough | Coventry | 15-01-2022 | 16:00 |
| Cheltenham | Charlton | 15-01-2022 | 16:00 |
| Norwich | Everton | 15-01-2022 | 16:00 |
| Bristol Rovers | Hartlepool | 15-01-2022 | 16:00 |
| Derby | Sheffield Utd | 15-01-2022 | 16:00 |
| Wolves | Southampton | 15-01-2022 | 16:00 |
| Lincoln | Cambridge United | 15-01-2022 | 16:00 |
| Mansfield Town | Walsall | 15-01-2022 | 16:00 |
| Port Vale | Swindon Town | 15-01-2022 | 16:00 |
| Grimsby | Altrincham | 15-01-2022 | 16:00 |
| Sheffield Wednesday | Plymouth | 15-01-2022 | 16:00 |
| Doncaster | Wigan | 15-01-2022 | 16:00 |
| Crewe | Shrewsbury | 15-01-2022 | 16:00 |
| Barnsley | Blackpool | 15-01-2022 | 16:00 |
| Exeter City | Scunthorpe | 15-01-2022 | 16:00 |
| Huddersfield | Swansea | 15-01-2022 | 16:00 |
| Oldham | Leyton Orient | 15-01-2022 | 16:00 |
| Bradford | Salford City | 15-01-2022 | 16:00 |
| Bolton | Ipswich | 15-01-2022 | 16:00 |
| Tranmere | Rochdale | 15-01-2022 | 16:00 |
| Burnley | Leicester | 15-01-2022 | 16:00 |
| Accrington ST | Sunderland | 15-01-2022 | 16:00 |
| Preston | Birmingham | 15-01-2022 | 16:00 |
| Fleetwood Town | Rotherham | 15-01-2022 | 16:00 |
| Middlesbrough | Reading | 15-01-2022 | 16:00 |
| Newcastle | Watford | 15-01-2022 | 16:00 |
| Carlisle | Crawley Town | 15-01-2022 | 16:00 |
| Annan Athletic | Forfar Athletic | 15-01-2022 | 16:00 |
| Stranraer | Stirling Albion | 15-01-2022 | 16:00 |
| Warrenpoint Town | Crusaders FC | 15-01-2022 | 16:00 |
| Ards | Dundela | 15-01-2022 | 16:00 |
| Linfield | Ballymena United | 15-01-2022 | 16:00 |
| Carrick Rangers | Glenavon FC | 15-01-2022 | 16:00 |
| Larne | Dungannon Swifts | 15-01-2022 | 16:00 |
| Annagh United | Ballinamallard United | 15-01-2022 | 16:00 |
| Ayr Utd | Morton | 15-01-2022 | 16:00 |
| Ballyclare Comrades | Institute | 15-01-2022 | 16:00 |
| Portadown | Coleraine FC | 15-01-2022 | 16:00 |
| Airdrie United | Falkirk | 15-01-2022 | 16:00 |
| Raith Rovers | Arbroath | 15-01-2022 | 16:00 |
| Dunfermline | Hamilton Academical | 15-01-2022 | 16:00 |
| Kelty Hearts | Edinburgh City | 15-01-2022 | 16:00 |
| Stenhousemuir | Cowdenbeath | 15-01-2022 | 16:00 |
| Alloa Athletic | Queen's Park | 15-01-2022 | 16:00 |
| Dumbarton | East Fife | 15-01-2022 | 16:00 |
| Middlesbrough | Reading | 15-01-2022 | 16:00 |
| Dergview | Loughgall | 15-01-2022 | 16:00 |
| Cove Rangers | Montrose | 15-01-2022 | 16:00 |
| Peterhead | Clyde | 15-01-2022 | 16:00 |
| Elgin City | Albion Rovers | 15-01-2022 | 16:00 |
| Inverness CT | Queen of the South | 15-01-2022 | 16:00 |
| Mallorca | Espanyol | 15-01-2022 | 16:00 |
| Wolves | Southampton | 15-01-2022 | 16:00 |
| OH Leuven | KV Mechelen | 15-01-2022 | 16:15 |
| Pisa | Frosinone | 15-01-2022 | 16:15 |
| ADO Den Haag | FC OSS | 15-01-2022 | 16:30 |
| Penafiel | Vilafranquense | 15-01-2022 | 16:30 |
| Boavista | GIL Vicente | 15-01-2022 | 16:30 |
| Penafiel | Vilafranquense | 15-01-2022 | 16:30 |
| Saint Etienne | Lens | 15-01-2022 | 17:00 |
| Istanbul Basaksehir | Konyaspor | 15-01-2022 | 17:00 |
| Kocaelispor | Ankaragucu | 15-01-2022 | 17:00 |
| Antalyaspor | Fenerbahce | 15-01-2022 | 17:00 |
| De Treffers | Katwijk | 15-01-2022 | 18:00 |
| De Treffers | Katwijk | 15-01-2022 | 18:00 |
| Salernitana | Lazio | 15-01-2022 | 18:00 |
| Aston Villa | Manchester United | 15-01-2022 | 18:30 |
| Zulte Waregem | Oostende | 15-01-2022 | 18:30 |
| Seraing United | Union St. Gilloise | 15-01-2022 | 18:30 |
| Borussia Monchengladbach | Bayer Leverkusen | 15-01-2022 | 18:30 |
| Sporting Gijon | Cadiz | 15-01-2022 | 18:30 |
| Girona | Rayo Vallecano | 15-01-2022 | 18:30 |
| NEC Nijmegen | Heracles | 15-01-2022 | 18:45 |
| Quevilly | Amiens | 15-01-2022 | 19:00 |
| Guingamp | Grenoble | 15-01-2022 | 19:00 |
| Nancy | Bastia | 15-01-2022 | 19:00 |
| Niort | Dunkerque | 15-01-2022 | 19:00 |
| Sochaux | Caen | 15-01-2022 | 19:00 |
| Rodez | Dijon | 15-01-2022 | 19:00 |
| Toulouse | PAU | 15-01-2022 | 19:00 |
| Nimes | Valenciennes | 15-01-2022 | 19:00 |
| SC Braga | Maritimo | 15-01-2022 | 19:00 |
| Feyenoord | Vitesse | 15-01-2022 | 20:00 |
| Twente | Heerenveen | 15-01-2022 | 20:00 |
| SV Darmstadt 98 | Karlsruher SC | 15-01-2022 | 20:30 |
| Club Brugge KV | St. Truiden | 15-01-2022 | 20:45 |
| Juventus | Udinese | 15-01-2022 | 20:45 |
| Paris Saint Germain | Stade Brestois 29 | 15-01-2022 | 21:00 |
| GO Ahead Eagles | Waalwijk | 15-01-2022 | 21:00 |
| Estoril | Arouca | 15-01-2022 | 21:30 |
| Real Betis | Sevilla | 15-01-2022 | 21:30 |
| Tuzlaspor | Alt?nordu | 16-01-2022 | 11:30 |
| Altay | Alanyaspor | 16-01-2022 | 11:30 |
| Nacional | Benfica B | 16-01-2022 | 12:00 |
| Utrecht | Ajax | 16-01-2022 | 12:15 |
| Sassuolo | Verona | 16-01-2022 | 12:30 |
| Hull City | Stoke City | 16-01-2022 | 13:00 |
| Rennes | Bordeaux | 16-01-2022 | 13:00 |
| Verl | FC Wurzburger Kickers | 16-01-2022 | 13:00 |
| Antwerp | Charleroi | 16-01-2022 | 13:30 |
| FC Schalke 04 | Holstein Kiel | 16-01-2022 | 13:30 |
| SV Sandhausen | Jahn Regensburg | 16-01-2022 | 13:30 |
| FC Heidenheim | FC Ingolstadt 04 | 16-01-2022 | 13:30 |
| Viktoria Berlin | Eintracht Braunschweig | 16-01-2022 | 14:00 |
| Elche | Villarreal | 16-01-2022 | 14:00 |
| Giresunspor | Kasimpasa | 16-01-2022 | 14:00 |
| Koninklijke HFC | AFC Amsterdam | 16-01-2022 | 14:30 |
| Cambuur | Sparta Rotterdam | 16-01-2022 | 14:30 |
| Groningen | PSV Eindhoven | 16-01-2022 | 14:30 |
| West Ham | Leeds | 16-01-2022 | 15:00 |
| Liverpool | Brentford | 16-01-2022 | 15:00 |
| Reims | Metz | 16-01-2022 | 15:00 |
| Lorient | Angers | 16-01-2022 | 15:00 |
| Strasbourg | Montpellier | 16-01-2022 | 15:00 |
| Monaco | Clermont Foot | 16-01-2022 | 15:00 |
| Venezia | Empoli | 16-01-2022 | 15:00 |
| Trofense | FC Porto B | 16-01-2022 | 15:00 |
| FC Augsburg | Eintracht Frankfurt | 16-01-2022 | 15:30 |
| AS Eupen | Cercle Brugge | 16-01-2022 | 16:00 |
| Monza | Perugia | 16-01-2022 | 16:15 |
| Spal | Benevento | 16-01-2022 | 16:15 |
| Pordenone | Lecce | 16-01-2022 | 16:15 |
| Santa Clara | Tondela | 16-01-2022 | 16:30 |
| Santa Clara | Tondela | 16-01-2022 | 16:30 |
| Fortuna Sittard | AZ Alkmaar | 16-01-2022 | 16:45 |
| Bursaspor | Erzurum BB | 16-01-2022 | 17:00 |
| Hatayspor | Galatasaray | 16-01-2022 | 17:00 |
| Estac Troyes | Lyon | 16-01-2022 | 17:05 |
| Tottenham | Arsenal | 16-01-2022 | 17:30 |
| Arminia Bielefeld | SpVgg Greuther Furth | 16-01-2022 | 17:30 |
| AS Roma | Cagliari | 16-01-2022 | 18:00 |
| Anderlecht | Standard Liege | 16-01-2022 | 18:30 |
| Vicenza Virtus | Alessandria | 16-01-2022 | 18:30 |
| Vizela | Sporting CP | 16-01-2022 | 19:00 |
| Famalicao | Pacos Ferreira | 16-01-2022 | 19:30 |
| Chaves | Varzim | 16-01-2022 | 20:30 |
| Atalanta | Inter | 16-01-2022 | 20:45 |
| Marseille | Lille | 16-01-2022 | 20:45 |
| Genk | Beerschot Wilrijk | 16-01-2022 | 21:00 |
| Belenenses | FC Porto | 16-01-2022 | 21:30 |
| Genclerbirligi | Adanaspor | 17-01-2022 | 18:00 |
| AC Milan | Spezia | 17-01-2022 | 18:30 |
| Bologna | Napoli | 17-01-2022 | 18:30 |
| Waldhof Mannheim | Borussia Dortmund II | 17-01-2022 | 19:00 |
| Academica | Rio Ave | 17-01-2022 | 19:00 |
| Farense | Leixoes | 17-01-2022 | 19:00 |
| Jong Ajax | Den Bosch | 17-01-2022 | 20:00 |
| Celtic | Hibernian | 17-01-2022 | 20:45 |
| Paris FC | LE Havre | 17-01-2022 | 20:45 |
| Laval | Annecy | 17-01-2022 | 20:45 |
| Cliftonville FC | Glentoran | 17-01-2022 | 20:45 |
| Celtic | Hibernian | 17-01-2022 | 20:45 |
| Fiorentina | Genoa | 17-01-2022 | 20:45 |
| Portimonense | Guimaraes | 17-01-2022 | 21:15 |
| Konyaspor | Adana Demirspor | 18-01-2022 | 15:00 |
| Lazio | Udinese | 18-01-2022 | 17:30 |
| Lucchese | Imolese | 18-01-2022 | 18:00 |
| FC Koln | Hamburger SV | 18-01-2022 | 18:30 |
| TSV 1860 Munich | Karlsruher SC | 18-01-2022 | 18:30 |
| Waalwijk | ADO Den Haag | 18-01-2022 | 18:45 |
| Mafra | Estrela | 18-01-2022 | 19:00 |
| Vitesse | DVS 33 Ermelo | 18-01-2022 | 20:00 |
| Real Betis | Alaves | 18-01-2022 | 20:00 |
| Burnley | Watford | 18-01-2022 | 20:30 |
| Fulham | Birmingham | 18-01-2022 | 20:45 |
| AFC Wimbledon | Portsmouth | 18-01-2022 | 20:45 |
| Sutton Utd | Colchester | 18-01-2022 | 20:45 |
| Maidenhead | Chesterfield | 18-01-2022 | 20:45 |
| Stevenage | Crawley Town | 18-01-2022 | 20:45 |
| Cambridge United | Doncaster | 18-01-2022 | 20:45 |
| Caernarfon Town | Bala Town | 18-01-2022 | 20:45 |
| Forest Green | Mansfield Town | 18-01-2022 | 20:45 |
| Cardiff MET | Newtown AFC | 18-01-2022 | 20:45 |
| Barry Town | Penybont | 18-01-2022 | 20:45 |
| Port Vale | Salford City | 18-01-2022 | 20:45 |
| Rotherham | Lincoln | 18-01-2022 | 20:45 |
| Stockport County | Eastleigh | 18-01-2022 | 20:45 |
| Cefn Druids AFC | The New Saints | 18-01-2022 | 20:45 |
| GAP Connah S Quay FC | Flint Town United | 18-01-2022 | 20:45 |
| Preston | Sheffield Utd | 18-01-2022 | 20:45 |
| Caernarfon Town | Bala Town | 18-01-2022 | 20:45 |
| Haverfordwest County AFC | Aberystwyth Town | 18-01-2022 | 20:45 |
| Morecambe | Wigan | 18-01-2022 | 20:45 |
| Carlisle | Hartlepool | 18-01-2022 | 20:45 |
| VfL BOCHUM | FSV Mainz 05 | 18-01-2022 | 20:45 |
| Caernarfon Town | Bala Town | 18-01-2022 | 20:45 |
| Heart OF Midlothian | ST Johnstone | 18-01-2022 | 20:45 |
| Livingston | Dundee | 18-01-2022 | 20:45 |
| Dundee Utd | ST Mirren | 18-01-2022 | 20:45 |
| Aberdeen | Rangers | 18-01-2022 | 20:45 |
| FC St. Pauli | Borussia Dortmund | 18-01-2022 | 20:45 |
| Ross County | Motherwell | 18-01-2022 | 20:45 |
| Brighton | Chelsea | 18-01-2022 | 21:00 |
| Heerenveen | GO Ahead Eagles | 18-01-2022 | 21:00 |
| Juventus | Sampdoria | 18-01-2022 | 21:00 |
| SC Covilha | Feirense | 18-01-2022 | 21:15 |
| Cadiz | Espanyol | 18-01-2022 | 21:30 |
| Real Sociedad | Atletico Madrid | 19-01-2022 | 01:00 |
| Athletic Club | Barcelona | 19-01-2022 | 01:00 |
| Barcelona | Rayo Vallecano | 19-01-2022 | 01:00 |
| Elche | Real Madrid | 19-01-2022 | 01:00 |
| Goztepe | Sivasspor | 19-01-2022 | 15:00 |
| Kayserispor | Istanbul Basaksehir | 19-01-2022 | 15:00 |
| Rizespor | Antalyaspor | 19-01-2022 | 15:00 |
| Sassuolo | Cagliari | 19-01-2022 | 17:30 |
| Lecco | PRO Vercelli | 19-01-2022 | 18:00 |
| Fenerbahce | Altay | 19-01-2022 | 18:00 |
| Hannover 96 | Borussia Monchengladbach | 19-01-2022 | 18:30 |
| RB Leipzig | Hansa Rostock | 19-01-2022 | 18:30 |
| RB Leipzig | Hansa Rostock | 19-01-2022 | 18:30 |
| Groningen | NEC Nijmegen | 19-01-2022 | 18:45 |
| Clermont Foot | Strasbourg | 19-01-2022 | 19:00 |
| Celta Vigo | Osasuna | 19-01-2022 | 19:00 |
| NAC Breda | PEC Zwolle | 19-01-2022 | 20:00 |
| Leicester | Tottenham | 19-01-2022 | 20:30 |
| Hull City | Blackburn | 19-01-2022 | 20:45 |
| Genk | KV Mechelen | 19-01-2022 | 20:45 |
| 1899 Hoffenheim | SC Freiburg | 19-01-2022 | 20:45 |
| Hertha Berlin | Union Berlin | 19-01-2022 | 20:45 |
| Brentford | Manchester United | 19-01-2022 | 21:00 |
| Reading | Luton | 19-01-2022 | 21:00 |
| Twente | AZ Alkmaar | 19-01-2022 | 21:00 |
| Inter | Empoli | 19-01-2022 | 21:00 |
| Lugo | Almeria | 19-01-2022 | 21:00 |
| Valencia | Sevilla | 19-01-2022 | 21:30 |
| Alanyaspor | Hatayspor | 20-01-2022 | 15:00 |
| Galatasaray | Kasimpasa | 20-01-2022 | 18:00 |
| PSV Eindhoven | Telstar | 20-01-2022 | 18:45 |
| Getafe | Granada CF | 20-01-2022 | 19:00 |
| Mallorca | Real Sociedad | 20-01-2022 | 19:00 |
| Arsenal | Liverpool | 20-01-2022 | 20:45 |
| Hibernian | Cove Rangers | 20-01-2022 | 20:45 |
| Ajax | Excelsior Maassluis | 20-01-2022 | 21:00 |
| AS Roma | Lecce | 20-01-2022 | 21:00 |
| Samsunspor | Kocaelispor | 21-01-2022 | 18:00 |
| Yeni Malatyaspor | Besiktas | 21-01-2022 | 18:00 |
| Fortuna Dusseldorf | FC Nurnberg | 21-01-2022 | 18:30 |
| Hamburger SV | FC St. Pauli | 21-01-2022 | 18:30 |
| Avranches | Sète | 21-01-2022 | 19:00 |
| RED Star FC 93 | Chambly Thelle FC | 21-01-2022 | 19:00 |
| Stade Briochin | Creteil | 21-01-2022 | 19:00 |
| Le Mans | Chateauroux | 21-01-2022 | 19:00 |
| Orleans | Boulogne | 21-01-2022 | 19:00 |
| Cholet | Bourg-en-bresse 01 | 21-01-2022 | 19:00 |
| Borussia Dortmund II | Freiburg II | 21-01-2022 | 19:00 |
| Villefranche | Laval | 21-01-2022 | 19:00 |
| Bastia-Borgo | Sedan | 21-01-2022 | 19:00 |
| RWDM | Lommel United | 21-01-2022 | 20:00 |
| Den Bosch | FC Eindhoven | 21-01-2022 | 20:00 |
| Jong PSV | Excelsior | 21-01-2022 | 20:00 |
| Helmond Sport | FC OSS | 21-01-2022 | 20:00 |
| MVV | FC Volendam | 21-01-2022 | 20:00 |
| Roda | ADO Den Haag | 21-01-2022 | 20:00 |
| De Graafschap | Almere City FC | 21-01-2022 | 20:00 |
| Roda | ADO Den Haag | 21-01-2022 | 20:00 |
| Arouca | Benfica | 21-01-2022 | 20:00 |
| Cambrian & Clydach | Carmarthen Town | 21-01-2022 | 20:30 |
| Guilsfield | Gresford Athletic | 21-01-2022 | 20:30 |
| Goytre United | Afan Lido | 21-01-2022 | 20:30 |
| Swansea University | Risca United | 21-01-2022 | 20:30 |
| Ammanford AFC | Port Talbot Town | 21-01-2022 | 20:30 |
| Llandudno | Holywell | 21-01-2022 | 20:30 |
| Holyhead Hotspur | Bangor City | 21-01-2022 | 20:30 |
| Eintracht Frankfurt | Arminia Bielefeld | 21-01-2022 | 20:30 |
| Parma | Frosinone | 21-01-2022 | 20:30 |
| Southend | King's Lynn Town | 21-01-2022 | 20:45 |
| Notts County | Barnet | 21-01-2022 | 20:45 |
| Oostende | Antwerp | 21-01-2022 | 20:45 |
| Penybont | Aberystwyth Town | 21-01-2022 | 20:45 |
| The New Saints | GAP Connah S Quay FC | 21-01-2022 | 20:45 |
| Cefn Druids AFC | Caernarfon Town | 21-01-2022 | 20:45 |
| Crusaders FC | Glentoran | 21-01-2022 | 20:45 |
| Larne | Cliftonville FC | 21-01-2022 | 20:45 |
| Edinburgh City | Stenhousemuir | 21-01-2022 | 20:45 |
| Rangers | Stirling Albion | 21-01-2022 | 20:45 |
| Verona | Bologna | 21-01-2022 | 20:45 |
| Watford | Norwich | 21-01-2022 | 21:00 |
| Watford | Norwich | 21-01-2022 | 21:00 |
| Ards | Annagh United | 21-01-2022 | 21:00 |
| Lyon | Saint Etienne | 21-01-2022 | 21:00 |
| Espanyol | Real Betis | 21-01-2022 | 21:00 |
| Tenerife | Oviedo | 21-01-2022 | 21:00 |
| Pacos Ferreira | Boavista | 21-01-2022 | 22:15 |
| Manisa BBSK | Genclerbirligi | 22-01-2022 | 11:30 |
| Antalyaspor | Gazi?ehir Gaziantep | 22-01-2022 | 11:30 |
| Vilafranquense | Nacional | 22-01-2022 | 12:00 |
| Bristol City | Cardiff | 22-01-2022 | 13:30 |
| Nottingham Forest | Derby | 22-01-2022 | 13:30 |
| Everton | Aston Villa | 22-01-2022 | 13:30 |
| SC Paderborn 07 | Werder Bremen | 22-01-2022 | 13:30 |
| Hansa Rostock | FC Heidenheim | 22-01-2022 | 13:30 |
| FC Ingolstadt 04 | SV Darmstadt 98 | 22-01-2022 | 13:30 |
| Swindon Town | Bristol Rovers | 22-01-2022 | 14:00 |
| FC Viktoria Koln | Verl | 22-01-2022 | 14:00 |
| FC Kaiserslautern | Viktoria Berlin | 22-01-2022 | 14:00 |
| SV Wehen | VfL Osnabruck | 22-01-2022 | 14:00 |
| FC Wurzburger Kickers | Waldhof Mannheim | 22-01-2022 | 14:00 |
| Eintracht Braunschweig | Hallescher FC | 22-01-2022 | 14:00 |
| como | Crotone | 22-01-2022 | 14:00 |
| Monza | Reggina | 22-01-2022 | 14:00 |
| Alessandria | Benevento | 22-01-2022 | 14:00 |
| Brescia | Ternana | 22-01-2022 | 14:00 |
| Spal | Pisa | 22-01-2022 | 14:00 |
| Levante | Cadiz | 22-01-2022 | 14:00 |
| Nuova Cosenza | Ascoli | 22-01-2022 | 14:00 |
| Sivasspor | Fenerbahce | 22-01-2022 | 14:00 |
| Adana Demirspor | Fatih Karagümrük | 22-01-2022 | 14:00 |
| Noordwijk | SVV Scheveningen | 22-01-2022 | 14:30 |
| AFC Amsterdam | Quick Boys | 22-01-2022 | 14:30 |
| GVVV Veenendaal | Spakenburg | 22-01-2022 | 14:30 |
| Virtus Entella | Gubbio | 22-01-2022 | 14:30 |
| Reggiana | Pistoiese | 22-01-2022 | 14:30 |
| Modena | Fermana | 22-01-2022 | 14:30 |
| Pontedera | Ancona | 22-01-2022 | 14:30 |
| Cesena | Viterbese | 22-01-2022 | 14:30 |
| Vis Pesaro | Teramo | 22-01-2022 | 14:30 |
| Olbia | Lucchese | 22-01-2022 | 14:30 |
| Pescara | Montevarchi Calcio | 22-01-2022 | 14:30 |
| Undy Athletic | Taffs Well | 22-01-2022 | 15:00 |
| Undy Athletic | Taffs Well | 22-01-2022 | 15:00 |
| Cwmbran Celtic | Trefelin | 22-01-2022 | 15:00 |
| Llantwit Major | llanelli AFC | 22-01-2022 | 15:00 |
| ASWH | Koninklijke HFC | 22-01-2022 | 15:00 |
| Ijsselmeervogels | De Treffers | 22-01-2022 | 15:00 |
| Auxerre | Paris FC | 22-01-2022 | 15:00 |
| Knockbreda | Ballyclare Comrades | 22-01-2022 | 15:00 |
| Cwmbran Celtic | Trefelin | 22-01-2022 | 15:00 |
| Genoa | Udinese | 22-01-2022 | 15:00 |
| Cardiff MET | Bala Town | 22-01-2022 | 15:30 |
| Barry Town | Flint Town United | 22-01-2022 | 15:30 |
| Newtown AFC | Haverfordwest County AFC | 22-01-2022 | 15:30 |
| Briton Ferry | Pontypridd Town | 22-01-2022 | 15:30 |
| Llanidloes Town | Colwyn Bay | 22-01-2022 | 15:30 |
| Ruthin Town | Airbus UK | 22-01-2022 | 15:30 |
| Penrhyncoch | Buckley Town | 22-01-2022 | 15:30 |
| Llanidloes Town | Colwyn Bay | 22-01-2022 | 15:30 |
| Conwy Borough | Prestatyn Town | 22-01-2022 | 15:30 |
| Katwijk | Volendam II | 22-01-2022 | 15:30 |
| Llangefni Town | Llanrhaeadr | 22-01-2022 | 15:30 |
| Llanidloes Town | Colwyn Bay | 22-01-2022 | 15:30 |
| Borussia Monchengladbach | Union Berlin | 22-01-2022 | 15:30 |
| HHC | Kozakken Boys | 22-01-2022 | 15:30 |
| Llanidloes Town | Colwyn Bay | 22-01-2022 | 15:30 |
| Bayer Leverkusen | FC Augsburg | 22-01-2022 | 15:30 |
| 1899 Hoffenheim | Borussia Dortmund | 22-01-2022 | 15:30 |
| SC Freiburg | VfB Stuttgart | 22-01-2022 | 15:30 |
| Llanidloes Town | Colwyn Bay | 22-01-2022 | 15:30 |
| SpVgg Greuther Furth | FSV Mainz 05 | 22-01-2022 | 15:30 |
| Leyton Orient | Port Vale | 22-01-2022 | 16:00 |
| Brentford | Wolves | 22-01-2022 | 16:00 |
| Charlton | Fleetwood Town | 22-01-2022 | 16:00 |
| Sutton Utd | Northampton | 22-01-2022 | 16:00 |
| Boreham Wood | Weymouth | 22-01-2022 | 16:00 |
| Woking | Wealdstone | 22-01-2022 | 16:00 |
| Maidenhead | FC Halifax Town | 22-01-2022 | 16:00 |
| Crawley Town | Tranmere | 22-01-2022 | 16:00 |
| Reading | Huddersfield | 22-01-2022 | 16:00 |
| Milton Keynes Dons | Doncaster | 22-01-2022 | 16:00 |
| Oxford United | Sheffield Wednesday | 22-01-2022 | 16:00 |
| Cambridge United | Crewe | 22-01-2022 | 16:00 |
| Ipswich | Accrington ST | 22-01-2022 | 16:00 |
| Bournemouth | Hull City | 22-01-2022 | 16:00 |
| Forest Green | Carlisle | 22-01-2022 | 16:00 |
| Solihull Moors | Dover | 22-01-2022 | 16:00 |
| Birmingham | Barnsley | 22-01-2022 | 16:00 |
| Coventry | QPR | 22-01-2022 | 16:00 |
| West Brom | Peterborough | 22-01-2022 | 16:00 |
| Walsall | Exeter City | 22-01-2022 | 16:00 |
| Burton Albion | AFC Wimbledon | 22-01-2022 | 16:00 |
| Yeovil Town | Wrexham | 22-01-2022 | 16:00 |
| Chesterfield | Aldershot Town | 22-01-2022 | 16:00 |
| Stoke City | Fulham | 22-01-2022 | 16:00 |
| Shrewsbury | Bolton | 22-01-2022 | 16:00 |
| Sheffield Utd | Luton | 22-01-2022 | 16:00 |
| Rotherham | Cheltenham | 22-01-2022 | 16:00 |
| Grimsby | Bromley | 22-01-2022 | 16:00 |
| Scunthorpe | Newport County | 22-01-2022 | 16:00 |
| Altrincham | Torquay | 22-01-2022 | 16:00 |
| Manchester United | West Ham | 22-01-2022 | 16:00 |
| Swansea | Preston | 22-01-2022 | 16:00 |
| Salford City | Colchester | 22-01-2022 | 16:00 |
| Leeds | Newcastle | 22-01-2022 | 16:00 |
| Rochdale | Bradford | 22-01-2022 | 16:00 |
| Wigan | Gillingham | 22-01-2022 | 16:00 |
| Cowdenbeath | Stranraer | 22-01-2022 | 16:00 |
| Harrogate Town | Oldham | 22-01-2022 | 16:00 |
| Plymouth | Lincoln | 22-01-2022 | 16:00 |
| Blackpool | Millwall | 22-01-2022 | 16:00 |
| Morecambe | Wycombe | 22-01-2022 | 16:00 |
| Barrow | Mansfield Town | 22-01-2022 | 16:00 |
| Hartlepool | Stevenage | 22-01-2022 | 16:00 |
| Sunderland | Portsmouth | 22-01-2022 | 16:00 |
| Boreham Wood | Weymouth | 22-01-2022 | 16:00 |
| Plymouth | Lincoln | 22-01-2022 | 16:00 |
| Ballymena United | Warrenpoint Town | 22-01-2022 | 16:00 |
| Coleraine FC | Carrick Rangers | 22-01-2022 | 16:00 |
| Dundela | Loughgall | 22-01-2022 | 16:00 |
| H&W Welders | Queen's University | 22-01-2022 | 16:00 |
| Linfield | Glenavon FC | 22-01-2022 | 16:00 |
| Ayr Utd | ST Mirren | 22-01-2022 | 16:00 |
| Livingston | Ross County | 22-01-2022 | 16:00 |
| Motherwell | Morton | 22-01-2022 | 16:00 |
| Kilmarnock | Dundee Utd | 22-01-2022 | 16:00 |
| Albion Rovers | Kelty Hearts | 22-01-2022 | 16:00 |
| Dungannon Swifts | Portadown | 22-01-2022 | 16:00 |
| Dunfermline | Inverness CT | 22-01-2022 | 16:00 |
| Ballymena United | Warrenpoint Town | 22-01-2022 | 16:00 |
| Coleraine FC | Carrick Rangers | 22-01-2022 | 16:00 |
| Cowdenbeath | Stranraer | 22-01-2022 | 16:00 |
| East Fife | Falkirk | 22-01-2022 | 16:00 |
| Clyde | Queen's Park | 22-01-2022 | 16:00 |
| Partick | Airdrie United | 22-01-2022 | 16:00 |
| Kelty Hearts | ST Johnstone | 22-01-2022 | 16:00 |
| Stirling Albion | Forfar Athletic | 22-01-2022 | 16:00 |
| Dumbarton | Dundee | 22-01-2022 | 16:00 |
| Arbroath | Darvel | 22-01-2022 | 16:00 |
| Ballymena United | Warrenpoint Town | 22-01-2022 | 16:00 |
| Coleraine FC | Carrick Rangers | 22-01-2022 | 16:00 |
| Ballinamallard United | Newry City AFC | 22-01-2022 | 16:00 |
| Ballymena United | Warrenpoint Town | 22-01-2022 | 16:00 |
| Coleraine FC | Carrick Rangers | 22-01-2022 | 16:00 |
| Dergview | Institute | 22-01-2022 | 16:00 |
| Ballymena United | Warrenpoint Town | 22-01-2022 | 16:00 |
| Coleraine FC | Carrick Rangers | 22-01-2022 | 16:00 |
| Aberdeen | Edinburgh City | 22-01-2022 | 16:00 |
| Peterhead | East Kilbride | 22-01-2022 | 16:00 |
| Elgin City | Annan Athletic | 22-01-2022 | 16:00 |
| Zaragoza | Valladolid | 22-01-2022 | 16:00 |
| Kortrijk | AS Eupen | 22-01-2022 | 16:15 |
| Villarreal | Mallorca | 22-01-2022 | 16:15 |
| Perugia | Pordenone | 22-01-2022 | 16:15 |
| Emmen | NAC Breda | 22-01-2022 | 16:30 |
| Moreirense | Santa Clara | 22-01-2022 | 16:30 |
| Varzim | Academica | 22-01-2022 | 16:30 |
| Stade Brestois 29 | Lille | 22-01-2022 | 17:00 |
| Istanbul Basaksehir | Goztepe | 22-01-2022 | 17:00 |
| Ankaragucu | Denizlispor | 22-01-2022 | 17:00 |
| Inter | Venezia | 22-01-2022 | 18:00 |
| Fuenlabrada | Las Palmas | 22-01-2022 | 18:15 |
| Dagenham & Redbridge | Stockport County | 22-01-2022 | 18:20 |
| Southampton | Manchester City | 22-01-2022 | 18:30 |
| Beerschot Wilrijk | OH Leuven | 22-01-2022 | 18:30 |
| St. Truiden | Seraing United | 22-01-2022 | 18:30 |
| VfL BOCHUM | FC Koln | 22-01-2022 | 18:30 |
| Alloa Athletic | Celtic | 22-01-2022 | 18:30 |
| Sevilla | Celta Vigo | 22-01-2022 | 18:30 |
| Vitesse | Groningen | 22-01-2022 | 18:45 |
| Dunkerque | Sochaux | 22-01-2022 | 19:00 |
| LE Havre | Rodez | 22-01-2022 | 19:00 |
| Amiens | Guingamp | 22-01-2022 | 19:00 |
| Valenciennes | Nancy | 22-01-2022 | 19:00 |
| Dijon | Quevilly | 22-01-2022 | 19:00 |
| Grenoble | Niort | 22-01-2022 | 19:00 |
| PAU | Nimes | 22-01-2022 | 19:00 |
| Bastia | Toulouse | 22-01-2022 | 19:00 |
| Tondela | Vizela | 22-01-2022 | 19:00 |
| AZ Alkmaar | Cambuur | 22-01-2022 | 20:00 |
| Heerenveen | PEC Zwolle | 22-01-2022 | 20:00 |
| Erzgebirge AUE | FC Schalke 04 | 22-01-2022 | 20:30 |
| Charleroi | Gent | 22-01-2022 | 20:45 |
| KVC Westerlo | Deinze | 22-01-2022 | 20:45 |
| Lazio | Atalanta | 22-01-2022 | 20:45 |
| Lens | Marseille | 22-01-2022 | 21:00 |
| Willem II | Twente | 22-01-2022 | 21:00 |
| Atletico Madrid | Valencia | 22-01-2022 | 21:00 |
| Malaga | Ibiza | 22-01-2022 | 21:00 |
| Sporting CP | SC Braga | 22-01-2022 | 21:30 |
| Kasimpasa | Kayserispor | 23-01-2022 | 11:30 |
| Adanaspor | Keçiörengücü | 23-01-2022 | 11:30 |
| Hatayspor | Rizespor | 23-01-2022 | 11:30 |
| Feirense | Mafra | 23-01-2022 | 12:00 |
| NEC Nijmegen | Feyenoord | 23-01-2022 | 12:15 |
| Cagliari | Fiorentina | 23-01-2022 | 12:30 |
| Metz | Nice | 23-01-2022 | 13:00 |
| SV Meppen | FSV Zwickau | 23-01-2022 | 13:00 |
| Standard Liege | Club Brugge KV | 23-01-2022 | 13:30 |
| Karlsruher SC | SV Sandhausen | 23-01-2022 | 13:30 |
| Hannover 96 | Dynamo Dresden | 23-01-2022 | 13:30 |
| Jahn Regensburg | Holstein Kiel | 23-01-2022 | 13:30 |
| MSV Duisburg | FC Saarbrucken | 23-01-2022 | 14:00 |
| Burgos | Leganes | 23-01-2022 | 14:00 |
| Granada CF | Osasuna | 23-01-2022 | 14:00 |
| Altay | Konyaspor | 23-01-2022 | 14:00 |
| Boluspor | Tuzlaspor | 23-01-2022 | 14:00 |
| Giresunspor | Alanyaspor | 23-01-2022 | 14:00 |
| Telstar | Jong Ajax | 23-01-2022 | 14:30 |
| TEC | Sparta Rotterdam II | 23-01-2022 | 14:30 |
| PSV Eindhoven | Ajax | 23-01-2022 | 14:30 |
| Heracles | GO Ahead Eagles | 23-01-2022 | 14:30 |
| Giana Erminio | Trento | 23-01-2022 | 14:30 |
| Fiorenzuola | Pro Sesto | 23-01-2022 | 14:30 |
| Giana Erminio | Trento | 23-01-2022 | 14:30 |
| Fiorenzuola | Pro Sesto | 23-01-2022 | 14:30 |
| Pro Patria | Piacenza | 23-01-2022 | 14:30 |
| PRO Vercelli | Juventus U23 | 23-01-2022 | 14:30 |
| Renate | Seregno | 23-01-2022 | 14:30 |
| Giana Erminio | Trento | 23-01-2022 | 14:30 |
| Fiorenzuola | Pro Sesto | 23-01-2022 | 14:30 |
| Giana Erminio | Trento | 23-01-2022 | 14:30 |
| Fiorenzuola | Pro Sesto | 23-01-2022 | 14:30 |
| Pergolettese | Sudtirol | 23-01-2022 | 14:30 |
| Giana Erminio | Trento | 23-01-2022 | 14:30 |
| Fiorenzuola | Pro Sesto | 23-01-2022 | 14:30 |
| Feralpisalo | Lecco | 23-01-2022 | 14:30 |
| Giana Erminio | Trento | 23-01-2022 | 14:30 |
| Fiorenzuola | Pro Sesto | 23-01-2022 | 14:30 |
| Giana Erminio | Trento | 23-01-2022 | 14:30 |
| Fiorenzuola | Pro Sesto | 23-01-2022 | 14:30 |
| Mantova | Albinoleffe | 23-01-2022 | 14:30 |
| Legnago Salus | Virtus Verona | 23-01-2022 | 14:30 |
| Giana Erminio | Trento | 23-01-2022 | 14:30 |
| Fiorenzuola | Pro Sesto | 23-01-2022 | 14:30 |
| Triestina | Padova | 23-01-2022 | 14:30 |
| Robur Siena | Imolese | 23-01-2022 | 14:30 |
| Grosseto | Carrarese | 23-01-2022 | 14:30 |
| Giana Erminio | Trento | 23-01-2022 | 14:30 |
| Fiorenzuola | Pro Sesto | 23-01-2022 | 14:30 |
| Giana Erminio | Trento | 23-01-2022 | 14:30 |
| Fiorenzuola | Pro Sesto | 23-01-2022 | 14:30 |
| Arsenal | Burnley | 23-01-2022 | 15:00 |
| Crystal Palace | Liverpool | 23-01-2022 | 15:00 |
| Leicester | Brighton | 23-01-2022 | 15:00 |
| Angers | Estac Troyes | 23-01-2022 | 15:00 |
| Nantes | Lorient | 23-01-2022 | 15:00 |
| Clermont Foot | Rennes | 23-01-2022 | 15:00 |
| Bordeaux | Strasbourg | 23-01-2022 | 15:00 |
| FC Magdeburg | Havelse | 23-01-2022 | 15:00 |
| Torino | Sassuolo | 23-01-2022 | 15:00 |
| Spezia | Sampdoria | 23-01-2022 | 15:00 |
| FC Porto B | Casa Pia | 23-01-2022 | 15:00 |
| Napoli | Salernitana | 23-01-2022 | 15:00 |
| RB Leipzig | VfL Wolfsburg | 23-01-2022 | 15:30 |
| RB Leipzig | VfL Wolfsburg | 23-01-2022 | 15:30 |
| Union St. Gilloise | Genk | 23-01-2022 | 16:00 |
| Excelsior Virton | Waasland-beveren | 23-01-2022 | 16:00 |
| Sporting Gijon | Amorebieta | 23-01-2022 | 16:00 |
| Vicenza Virtus | Cittadella | 23-01-2022 | 16:15 |
| Real Madrid | Elche | 23-01-2022 | 16:15 |
| Guimaraes | Estoril | 23-01-2022 | 16:30 |
| Rio Ave | Farense | 23-01-2022 | 16:30 |
| Maritimo | Belenenses | 23-01-2022 | 16:30 |
| Sparta Rotterdam | Utrecht | 23-01-2022 | 16:45 |
| Galatasaray | Trabzonspor | 23-01-2022 | 17:00 |
| Montpellier | Monaco | 23-01-2022 | 17:05 |
| Chelsea | Tottenham | 23-01-2022 | 17:30 |
| Hertha Berlin | Bayern Munich | 23-01-2022 | 17:30 |
| Monterosi | Potenza | 23-01-2022 | 17:30 |
| Foggia | Latina | 23-01-2022 | 17:30 |
| Avellino | SS Monopoli | 23-01-2022 | 17:30 |
| AZ Picerno | Turris | 23-01-2022 | 17:30 |
| Bari | Catania | 23-01-2022 | 17:30 |
| Taranto | Paganese | 23-01-2022 | 17:30 |
| Virtus Francavilla | Messina | 23-01-2022 | 17:30 |
| Vibonese | Fidelis Andria | 23-01-2022 | 17:30 |
| Empoli | AS Roma | 23-01-2022 | 18:00 |
| Huesca | Ponferradina | 23-01-2022 | 18:15 |
| Girona | Lugo | 23-01-2022 | 18:15 |
| KV Mechelen | Anderlecht | 23-01-2022 | 18:30 |
| Real Sociedad | Getafe | 23-01-2022 | 18:30 |
| Rayo Vallecano | Athletic Club | 23-01-2022 | 18:30 |
| Lecce | Cremonese | 23-01-2022 | 18:30 |
| GIL Vicente | Portimonense | 23-01-2022 | 19:00 |
| Benfica B | Penafiel | 23-01-2022 | 19:00 |
| Royal Excel Mouscron | Lierse Kempenzonen | 23-01-2022 | 20:00 |
| Waalwijk | Fortuna Sittard | 23-01-2022 | 20:00 |
| Estrela | Trofense | 23-01-2022 | 20:30 |
| Paris Saint Germain | Reims | 23-01-2022 | 20:45 |
| AC Milan | Juventus | 23-01-2022 | 20:45 |
| Cercle Brugge | Zulte Waregem | 23-01-2022 | 21:00 |
| Alaves | Barcelona | 23-01-2022 | 21:00 |
| Alcorcon | Mirandes | 23-01-2022 | 21:00 |
| FC Porto | Famalicao | 23-01-2022 | 21:30 |
| Academico Viseu | SC Covilha | 24-01-2022 | 16:30 |
| Caen | Ajaccio | 24-01-2022 | 20:45 |
| Blackburn | Middlesbrough | 24-01-2022 | 20:45 |
| Annecy | Concarneau | 24-01-2022 | 20:45 |
| Annecy | Concarneau | 24-01-2022 | 20:45 |
| Annecy | Concarneau | 24-01-2022 | 20:45 |
| Real Sociedad II | FC Cartagena | 24-01-2022 | 21:00 |
| Almeria | Eibar | 24-01-2022 | 21:00 |
| Catanzaro | Palermo | 24-01-2022 | 21:00 |
| Leixoes | Chaves | 24-01-2022 | 21:15 |
| Antwerp | St. Truiden | 25-01-2022 | 18:45 |
| VfL Osnabruck | FC Wurzburger Kickers | 25-01-2022 | 19:00 |
| Waldhof Mannheim | FC Viktoria Koln | 25-01-2022 | 19:00 |
| Freiburg II | Türkgücü-Ataspor | 25-01-2022 | 19:00 |
| Hallescher FC | Viktoria Berlin | 25-01-2022 | 19:00 |
| TSV 1860 Munich | FC Kaiserslautern | 25-01-2022 | 19:00 |
| RWDM | KVC Westerlo | 25-01-2022 | 20:00 |
| Le Mans | Cholet | 25-01-2022 | 20:00 |
| QPR | Swansea | 25-01-2022 | 20:45 |
| Leyton Orient | Newport County | 25-01-2022 | 20:45 |
| AFC Wimbledon | Ipswich | 25-01-2022 | 20:45 |
| Bromley | Woking | 25-01-2022 | 20:45 |
| Wealdstone | Notts County | 25-01-2022 | 20:45 |
| Luton | Bristol City | 25-01-2022 | 20:45 |
| Gillingham | Shrewsbury | 25-01-2022 | 20:45 |
| Aldershot Town | Southend | 25-01-2022 | 20:45 |
| Dover | Eastleigh | 25-01-2022 | 20:45 |
| Glentoran | Coleraine FC | 25-01-2022 | 20:45 |
| King's Lynn Town | Altrincham | 25-01-2022 | 20:45 |
| Birmingham | Peterborough | 25-01-2022 | 20:45 |
| Coventry | Stoke City | 25-01-2022 | 20:45 |
| Nottingham Forest | Barnsley | 25-01-2022 | 20:45 |
| Weymouth | Dagenham & Redbridge | 25-01-2022 | 20:45 |
| Scunthorpe | Bristol Rovers | 25-01-2022 | 20:45 |
| Stockport County | Maidenhead | 25-01-2022 | 20:45 |
| Wrexham | Grimsby | 25-01-2022 | 20:45 |
| Torquay | Solihull Moors | 25-01-2022 | 20:45 |
| FC Halifax Town | Boreham Wood | 25-01-2022 | 20:45 |
| Fleetwood Town | Plymouth | 25-01-2022 | 20:45 |
| Glentoran | Coleraine FC | 25-01-2022 | 20:45 |
| Barrow | Salford City | 25-01-2022 | 20:45 |
| Warrenpoint Town | Larne | 25-01-2022 | 20:45 |
| Glentoran | Coleraine FC | 25-01-2022 | 20:45 |
| Cliftonville FC | Linfield | 25-01-2022 | 20:45 |
| Carrick Rangers | Ballymena United | 25-01-2022 | 20:45 |
| Glenavon FC | Dungannon Swifts | 25-01-2022 | 20:45 |
| Portadown | Crusaders FC | 25-01-2022 | 20:45 |
| Loughgall | Ards | 25-01-2022 | 20:45 |
| Clyde | Airdrie United | 25-01-2022 | 20:45 |
| ST Mirren | Aberdeen | 25-01-2022 | 20:45 |
| Elgin City | Kelty Hearts | 25-01-2022 | 20:45 |
| Gent | Oostende | 25-01-2022 | 21:00 |
| Charleroi | Kortrijk | 25-01-2022 | 21:00 |
| Sudtirol | Triestina | 26-01-2022 | 18:00 |
| Zulte Waregem | OH Leuven | 26-01-2022 | 18:45 |
| AS Eupen | Standard Liege | 26-01-2022 | 18:45 |
| Angers | Saint Etienne | 26-01-2022 | 19:00 |
| MSV Duisburg | FC Magdeburg | 26-01-2022 | 19:00 |
| FC Saarbrucken | Borussia Dortmund II | 26-01-2022 | 19:00 |
| Verl | SV Meppen | 26-01-2022 | 19:00 |
| Havelse | SV Wehen | 26-01-2022 | 19:00 |
| FSV Zwickau | Eintracht Braunschweig | 26-01-2022 | 19:00 |
| Heart OF Midlothian | Celtic | 26-01-2022 | 20:45 |
| Motherwell | Hibernian | 26-01-2022 | 20:45 |
| Rangers | Livingston | 26-01-2022 | 20:45 |
| Dundee Utd | Ross County | 26-01-2022 | 20:45 |
| ST Johnstone | Dundee | 26-01-2022 | 20:45 |
| West Brom | Preston | 26-01-2022 | 21:00 |
| Anderlecht | Cercle Brugge | 26-01-2022 | 21:00 |
| Seraing United | Beerschot Wilrijk | 26-01-2022 | 21:00 |
| Club Brugge KV | Union St. Gilloise | 27-01-2022 | 20:45 |
| Lens | Monaco | 28-01-2022 | 01:00 |
| Paris Saint Germain | Nice | 28-01-2022 | 01:00 |
| Versailles | Toulouse | 28-01-2022 | 01:00 |
| Reims | Bastia | 28-01-2022 | 01:00 |
| Nantes | Stade Brestois 29 | 28-01-2022 | 01:00 |
| Nancy | Amiens | 28-01-2022 | 01:00 |
| Bergerac | Saint Etienne | 28-01-2022 | 01:00 |
| Marseille | Montpellier | 28-01-2022 | 01:00 |
| Cholet | Creteil | 28-01-2022 | 19:00 |
| FC Wurzburger Kickers | Freiburg II | 28-01-2022 | 19:00 |
| Farense | Estrela | 28-01-2022 | 19:00 |
| Lommel United | Lierse Kempenzonen | 28-01-2022 | 20:00 |
| FC OSS | Den Bosch | 28-01-2022 | 20:00 |
| Risca United | Llantwit Major | 28-01-2022 | 20:30 |
| Afan Lido | Cambrian & Clydach | 28-01-2022 | 20:30 |
| Ammanford AFC | Goytre United | 28-01-2022 | 20:30 |
| Airbus UK | Conwy Borough | 28-01-2022 | 20:30 |
| Ruthin Town | Llandudno | 28-01-2022 | 20:30 |
| Caernarfon Town | The New Saints | 28-01-2022 | 20:45 |
| Huddersfield | Stoke City | 28-01-2022 | 20:45 |
| Caernarfon Town | The New Saints | 28-01-2022 | 20:45 |
| Haverfordwest County AFC | Penybont | 28-01-2022 | 20:45 |
| St. Truiden | Charleroi | 28-01-2022 | 20:45 |
| Ballymena United | Cliftonville FC | 28-01-2022 | 20:45 |
| Caernarfon Town | The New Saints | 28-01-2022 | 20:45 |
| Ballymena United | Cliftonville FC | 28-01-2022 | 20:45 |
| Morton | Raith Rovers | 28-01-2022 | 20:45 |
| Ballymena United | Cliftonville FC | 28-01-2022 | 20:45 |
| Ballymena United | Cliftonville FC | 28-01-2022 | 20:45 |
| Ballymena United | Cliftonville FC | 28-01-2022 | 20:45 |
| Aberystwyth Town | Cefn Druids AFC | 28-01-2022 | 21:00 |
| Trofense | Benfica B | 28-01-2022 | 21:15 |
| OH Leuven | Genk | 29-01-2022 | 01:00 |
| Ross County | Rangers | 29-01-2022 | 13:30 |
| Borussia Dortmund II | VfL Osnabruck | 29-01-2022 | 14:00 |
| FC Kaiserslautern | Hallescher FC | 29-01-2022 | 14:00 |
| SV Wehen | MSV Duisburg | 29-01-2022 | 14:00 |
| Viktoria Berlin | FSV Zwickau | 29-01-2022 | 14:00 |
| Albinoleffe | Giana Erminio | 29-01-2022 | 14:30 |
| Albinoleffe | Giana Erminio | 29-01-2022 | 14:30 |
| Lecco | Triestina | 29-01-2022 | 14:30 |
| Seregno | Fiorenzuola | 29-01-2022 | 14:30 |
| Pro Sesto | Renate | 29-01-2022 | 14:30 |
| Albinoleffe | Giana Erminio | 29-01-2022 | 14:30 |
| Juventus U23 | Feralpisalo | 29-01-2022 | 14:30 |
| Albinoleffe | Giana Erminio | 29-01-2022 | 14:30 |
| Sudtirol | Legnago Salus | 29-01-2022 | 14:30 |
| Albinoleffe | Giana Erminio | 29-01-2022 | 14:30 |
| Piacenza | Mantova | 29-01-2022 | 14:30 |
| Albinoleffe | Giana Erminio | 29-01-2022 | 14:30 |
| Albinoleffe | Giana Erminio | 29-01-2022 | 14:30 |
| Virtus Verona | Pergolettese | 29-01-2022 | 14:30 |
| Padova | Pro Patria | 29-01-2022 | 14:30 |
| Albinoleffe | Giana Erminio | 29-01-2022 | 14:30 |
| Albinoleffe | Giana Erminio | 29-01-2022 | 14:30 |
| Albinoleffe | Giana Erminio | 29-01-2022 | 14:30 |
| Quick Boys | Excelsior Maassluis | 29-01-2022 | 15:00 |
| Rijnsburgse Boys | Ijsselmeervogels | 29-01-2022 | 15:00 |
| Kozakken Boys | Noordwijk | 29-01-2022 | 15:00 |
| Volendam II | ASWH | 29-01-2022 | 15:00 |
| Spakenburg | AFC Amsterdam | 29-01-2022 | 15:00 |
| Pontypridd Town | Swansea University | 29-01-2022 | 15:30 |
| Port Talbot Town | Taffs Well | 29-01-2022 | 15:30 |
| Gresford Athletic | Holyhead Hotspur | 29-01-2022 | 15:30 |
| Buckley Town | Llanidloes Town | 29-01-2022 | 15:30 |
| GAP Connah S Quay FC | Barry Town | 29-01-2022 | 15:30 |
| llanelli AFC | Undy Athletic | 29-01-2022 | 15:30 |
| Flint Town United | Cardiff MET | 29-01-2022 | 15:30 |
| Holywell | Guilsfield | 29-01-2022 | 15:30 |
| Carmarthen Town | Cwmbran Celtic | 29-01-2022 | 15:30 |
| Prestatyn Town | Penrhyncoch | 29-01-2022 | 15:30 |
| Colwyn Bay | Llangefni Town | 29-01-2022 | 15:30 |
| Sparta Rotterdam II | GVVV Veenendaal | 29-01-2022 | 15:30 |
| Bangor City | Llanrhaeadr | 29-01-2022 | 15:30 |
| Carmarthen Town | Cwmbran Celtic | 29-01-2022 | 15:30 |
| HHC | Katwijk | 29-01-2022 | 15:30 |
| Millwall | West Brom | 29-01-2022 | 16:00 |
| Fulham | Blackpool | 29-01-2022 | 16:00 |
| QPR | Reading | 29-01-2022 | 16:00 |
| AFC Wimbledon | Shrewsbury | 29-01-2022 | 16:00 |
| Barnet | Stockport County | 29-01-2022 | 16:00 |
| Bromley | Notts County | 29-01-2022 | 16:00 |
| Boreham Wood | King's Lynn Town | 29-01-2022 | 16:00 |
| Dagenham & Redbridge | FC Halifax Town | 29-01-2022 | 16:00 |
| Woking | Yeovil Town | 29-01-2022 | 16:00 |
| Stevenage | Harrogate Town | 29-01-2022 | 16:00 |
| Luton | Blackburn | 29-01-2022 | 16:00 |
| Wycombe | Milton Keynes Dons | 29-01-2022 | 16:00 |
| Gillingham | Oxford United | 29-01-2022 | 16:00 |
| Colchester | Swindon Town | 29-01-2022 | 16:00 |
| Northampton | Salford City | 29-01-2022 | 16:00 |
| Dover | Southend | 29-01-2022 | 16:00 |
| Cheltenham | Wigan | 29-01-2022 | 16:00 |
| Glentoran | Warrenpoint Town | 29-01-2022 | 16:00 |
| Solihull Moors | Altrincham | 29-01-2022 | 16:00 |
| Bristol Rovers | Walsall | 29-01-2022 | 16:00 |
| Lincoln | Burton Albion | 29-01-2022 | 16:00 |
| Weymouth | Aldershot Town | 29-01-2022 | 16:00 |
| Mansfield Town | Leyton Orient | 29-01-2022 | 16:00 |
| Newport County | Barrow | 29-01-2022 | 16:00 |
| Celtic | Dundee Utd | 29-01-2022 | 16:00 |
| Port Vale | Scunthorpe | 29-01-2022 | 16:00 |
| Grimsby | Wealdstone | 29-01-2022 | 16:00 |
| Sheffield Wednesday | Ipswich | 29-01-2022 | 16:00 |
| Doncaster | Plymouth | 29-01-2022 | 16:00 |
| Crewe | Rotherham | 29-01-2022 | 16:00 |
| Barnsley | Bournemouth | 29-01-2022 | 16:00 |
| Hull City | Swansea | 29-01-2022 | 16:00 |
| Exeter City | Hartlepool | 29-01-2022 | 16:00 |
| Wrexham | Maidenhead | 29-01-2022 | 16:00 |
| Oldham | Rochdale | 29-01-2022 | 16:00 |
| Bradford | Crawley Town | 29-01-2022 | 16:00 |
| Bolton | Sunderland | 29-01-2022 | 16:00 |
| Tranmere | Forest Green | 29-01-2022 | 16:00 |
| Accrington ST | Morecambe | 29-01-2022 | 16:00 |
| Preston | Bristol City | 29-01-2022 | 16:00 |
| Fleetwood Town | Cambridge United | 29-01-2022 | 16:00 |
| Glentoran | Warrenpoint Town | 29-01-2022 | 16:00 |
| Middlesbrough | Coventry | 29-01-2022 | 16:00 |
| Carlisle | Sutton Utd | 29-01-2022 | 16:00 |
| Annan Athletic | Stirling Albion | 29-01-2022 | 16:00 |
| Boreham Wood | King's Lynn Town | 29-01-2022 | 16:00 |
| Queen of the South | Dunfermline | 29-01-2022 | 16:00 |
| Coleraine FC | Linfield | 29-01-2022 | 16:00 |
| Newry City AFC | Dundela | 29-01-2022 | 16:00 |
| H&W Welders | Institute | 29-01-2022 | 16:00 |
| Queen's University | Ards | 29-01-2022 | 16:00 |
| Glentoran | Warrenpoint Town | 29-01-2022 | 16:00 |
| Crusaders FC | Glenavon FC | 29-01-2022 | 16:00 |
| Annagh United | Dergview | 29-01-2022 | 16:00 |
| Ballyclare Comrades | Ballinamallard United | 29-01-2022 | 16:00 |
| Hibernian | Livingston | 29-01-2022 | 16:00 |
| Heart OF Midlothian | Motherwell | 29-01-2022 | 16:00 |
| Kilmarnock | Inverness CT | 29-01-2022 | 16:00 |
| Loughgall | Knockbreda | 29-01-2022 | 16:00 |
| Hamilton Academical | Ayr Utd | 29-01-2022 | 16:00 |
| Albion Rovers | Cowdenbeath | 29-01-2022 | 16:00 |
| Queen's Park | Airdrie United | 29-01-2022 | 16:00 |
| Dungannon Swifts | Carrick Rangers | 29-01-2022 | 16:00 |
| Celtic | Dundee Utd | 29-01-2022 | 16:00 |
| Coleraine FC | Linfield | 29-01-2022 | 16:00 |
| Newry City AFC | Dundela | 29-01-2022 | 16:00 |
| East Fife | Peterhead | 29-01-2022 | 16:00 |
| Clyde | Alloa Athletic | 29-01-2022 | 16:00 |
| Kelty Hearts | Stranraer | 29-01-2022 | 16:00 |
| Stenhousemuir | Elgin City | 29-01-2022 | 16:00 |
| Dumbarton | Cove Rangers | 29-01-2022 | 16:00 |
| Dundee | ST Mirren | 29-01-2022 | 16:00 |
| Arbroath | Partick | 29-01-2022 | 16:00 |
| Middlesbrough | Coventry | 29-01-2022 | 16:00 |
| Coleraine FC | Linfield | 29-01-2022 | 16:00 |
| Newry City AFC | Dundela | 29-01-2022 | 16:00 |
| Montrose | Falkirk | 29-01-2022 | 16:00 |
| Coleraine FC | Linfield | 29-01-2022 | 16:00 |
| Newry City AFC | Dundela | 29-01-2022 | 16:00 |
| Forfar Athletic | Edinburgh City | 29-01-2022 | 16:00 |
| Coleraine FC | Linfield | 29-01-2022 | 16:00 |
| Newry City AFC | Dundela | 29-01-2022 | 16:00 |
| Aberdeen | ST Johnstone | 29-01-2022 | 16:00 |
| Forfar Athletic | Edinburgh City | 29-01-2022 | 16:00 |
| Beerschot Wilrijk | Zulte Waregem | 29-01-2022 | 16:15 |
| FC Magdeburg | FC Saarbrucken | 29-01-2022 | 17:55 |
| Eastleigh | Chesterfield | 29-01-2022 | 18:20 |
| Peterborough | Sheffield Utd | 29-01-2022 | 18:30 |
| Seraing United | AS Eupen | 29-01-2022 | 18:30 |
| Larne | Portadown | 29-01-2022 | 18:30 |
| FC Eindhoven | MVV | 29-01-2022 | 18:45 |
| Cercle Brugge | Oostende | 29-01-2022 | 20:45 |
| Deinze | Excelsior Virton | 29-01-2022 | 20:45 |
| Bala Town | Newtown AFC | 29-01-2022 | 20:45 |
| Excelsior | Emmen | 29-01-2022 | 21:00 |
| Amorebieta | Girona | 30-01-2022 | 01:00 |
| Eibar | Huesca | 30-01-2022 | 01:00 |
| Oviedo | Almeria | 30-01-2022 | 01:00 |
| Mirandes | Malaga | 30-01-2022 | 01:00 |
| Lugo | Burgos | 30-01-2022 | 01:00 |
| Ponferradina | Tenerife | 30-01-2022 | 01:00 |
| Valladolid | Sporting Gijon | 30-01-2022 | 01:00 |
| Leganes | Alcorcon | 30-01-2022 | 01:00 |
| Ibiza | Zaragoza | 30-01-2022 | 01:00 |
| FC Cartagena | Fuenlabrada | 30-01-2022 | 01:00 |
| Las Palmas | Real Sociedad II | 30-01-2022 | 01:00 |
| Nacional | FC Porto B | 30-01-2022 | 12:00 |
| VVV Venlo | Dordrecht | 30-01-2022 | 12:15 |
| FC Viktoria Koln | TSV 1860 Munich | 30-01-2022 | 13:00 |
| Union St. Gilloise | Anderlecht | 30-01-2022 | 13:30 |
| Rio Ave | Varzim | 30-01-2022 | 13:45 |
| SV Meppen | Waldhof Mannheim | 30-01-2022 | 14:00 |
| Derby | Birmingham | 30-01-2022 | 14:30 |
| Koninklijke HFC | De Treffers | 30-01-2022 | 14:30 |
| Almere City FC | Telstar | 30-01-2022 | 14:30 |
| Virtus Entella | Modena | 30-01-2022 | 14:30 |
| Reggiana | Robur Siena | 30-01-2022 | 14:30 |
| Lucchese | Ancona | 30-01-2022 | 14:30 |
| Pistoiese | Vis Pesaro | 30-01-2022 | 14:30 |
| Imolese | Teramo | 30-01-2022 | 14:30 |
| Cesena | Olbia | 30-01-2022 | 14:30 |
| Montevarchi Calcio | Pontedera | 30-01-2022 | 14:30 |
| Gubbio | Grosseto | 30-01-2022 | 14:30 |
| Viterbese | Pescara | 30-01-2022 | 14:30 |
| Fermana | Carrarese | 30-01-2022 | 14:30 |
| Chaves | Feirense | 30-01-2022 | 15:00 |
| Gent | Antwerp | 30-01-2022 | 16:00 |
| Waasland-beveren | KVC Westerlo | 30-01-2022 | 16:00 |
| Vizela | Guimaraes | 30-01-2022 | 16:30 |
| SC Covilha | Vilafranquense | 30-01-2022 | 16:30 |
| Mafra | Academico Viseu | 30-01-2022 | 16:30 |
| Estoril | Pacos Ferreira | 30-01-2022 | 16:30 |
| ADO Den Haag | De Graafschap | 30-01-2022 | 16:45 |
| Cardiff | Nottingham Forest | 30-01-2022 | 17:00 |
| Latina | Taranto | 30-01-2022 | 17:30 |
| Turris | Vibonese | 30-01-2022 | 17:30 |
| Paganese | Bari | 30-01-2022 | 17:30 |
| Fidelis Andria | Città di Campobasso | 30-01-2022 | 17:30 |
| Potenza | Avellino | 30-01-2022 | 17:30 |
| SS Monopoli | Virtus Francavilla | 30-01-2022 | 17:30 |
| Palermo | Monterosi | 30-01-2022 | 17:30 |
| Messina | AZ Picerno | 30-01-2022 | 17:30 |
| Catania | Catanzaro | 30-01-2022 | 17:30 |
| Standard Liege | KV Mechelen | 30-01-2022 | 18:30 |
| Academica | Leixoes | 30-01-2022 | 18:30 |
| SC Braga | Moreirense | 30-01-2022 | 19:00 |
| RWDM | Royal Excel Mouscron | 30-01-2022 | 20:00 |
| Kortrijk | Club Brugge KV | 30-01-2022 | 21:00 |
| FC Porto | Maritimo | 30-01-2022 | 21:30 |
| Casa Pia | Penafiel | 31-01-2022 | 18:00 |
| Eintracht Braunschweig | Verl | 31-01-2022 | 19:00 |
| Portimonense | Tondela | 31-01-2022 | 20:00 |
| Portsmouth | Charlton | 31-01-2022 | 20:45 |
| Juve Stabia | Foggia | 31-01-2022 | 21:00 |
| Famalicao | Arouca | 31-01-2022 | 22:15 |
| Gent | Club Brugge KV | 01-02-2022 | 01:00 |
| AS Eupen | Anderlecht | 01-02-2022 | 01:00 |
| Giana Erminio | Mantova | 01-02-2022 | 18:00 |
| Giana Erminio | Mantova | 01-02-2022 | 18:00 |
| Pro Patria | Trento | 01-02-2022 | 18:00 |
| PRO Vercelli | Pro Sesto | 01-02-2022 | 18:00 |
| Renate | Fiorenzuola | 01-02-2022 | 18:00 |
| Giana Erminio | Mantova | 01-02-2022 | 18:00 |
| Giana Erminio | Mantova | 01-02-2022 | 18:00 |
| Pergolettese | Padova | 01-02-2022 | 18:00 |
| Sudtirol | Albinoleffe | 01-02-2022 | 18:00 |
| Giana Erminio | Mantova | 01-02-2022 | 18:00 |
| Feralpisalo | Seregno | 01-02-2022 | 18:00 |
| Piacenza | Virtus Verona | 01-02-2022 | 18:00 |
| Giana Erminio | Mantova | 01-02-2022 | 18:00 |
| Giana Erminio | Mantova | 01-02-2022 | 18:00 |
| Legnago Salus | Lecco | 01-02-2022 | 18:00 |
| Giana Erminio | Mantova | 01-02-2022 | 18:00 |
| Triestina | Juventus U23 | 01-02-2022 | 18:00 |
| Giana Erminio | Mantova | 01-02-2022 | 18:00 |
| Giana Erminio | Mantova | 01-02-2022 | 18:00 |
| AFC Wimbledon | Cheltenham | 01-02-2022 | 20:45 |
| Southend | Barnet | 01-02-2022 | 20:45 |
| Swindon Town | Crawley Town | 01-02-2022 | 20:45 |
| Port Vale | Forest Green | 01-02-2022 | 20:45 |
| Sheffield Wednesday | Morecambe | 01-02-2022 | 20:45 |
| Doncaster | Rotherham | 01-02-2022 | 20:45 |
| Salford City | Carlisle | 01-02-2022 | 20:45 |
| Bradford | Leyton Orient | 01-02-2022 | 20:45 |
| Wigan | Oxford United | 01-02-2022 | 20:45 |
| Tranmere | Stevenage | 01-02-2022 | 20:45 |
| Hibernian | Heart OF Midlothian | 01-02-2022 | 20:45 |
| Livingston | ST Johnstone | 01-02-2022 | 20:45 |
| ST Mirren | Motherwell | 01-02-2022 | 20:45 |
| Dundee | Dundee Utd | 01-02-2022 | 20:45 |
| Ross County | Aberdeen | 01-02-2022 | 20:45 |
| Bolton | Cambridge United | 01-02-2022 | 21:00 |
| Santa Clara | Boavista | 02-02-2022 | 01:00 |
| Belenenses | Sporting CP | 02-02-2022 | 01:00 |
| Santa Clara | Boavista | 02-02-2022 | 01:00 |
| Leixoes | Mafra | 02-02-2022 | 16:30 |
| Rio Ave | SC Covilha | 02-02-2022 | 18:00 |
| Monterosi | Bari | 02-02-2022 | 18:00 |
| Paganese | Latina | 02-02-2022 | 18:00 |
| Fidelis Andria | Catania | 02-02-2022 | 18:00 |
| SS Monopoli | Turris | 02-02-2022 | 18:00 |
| Taranto | Città di Campobasso | 02-02-2022 | 18:00 |
| Palermo | Messina | 02-02-2022 | 18:00 |
| Vibonese | Virtus Francavilla | 02-02-2022 | 18:00 |
| Catanzaro | AZ Picerno | 02-02-2022 | 18:00 |
| Celtic | Rangers | 02-02-2022 | 20:45 |
| Celtic | Rangers | 02-02-2022 | 20:45 |
| Virtus Entella | Montevarchi Calcio | 02-02-2022 | 21:00 |
| Reggiana | Modena | 02-02-2022 | 21:00 |
| Imolese | Viterbese | 02-02-2022 | 21:00 |
| Pontedera | Vis Pesaro | 02-02-2022 | 21:00 |
| Cesena | Lucchese | 02-02-2022 | 21:00 |
| Robur Siena | Teramo | 02-02-2022 | 21:00 |
| Grosseto | Pistoiese | 02-02-2022 | 21:00 |
| Olbia | Ancona | 02-02-2022 | 21:00 |
| Fermana | Gubbio | 02-02-2022 | 21:00 |
| Pescara | Carrarese | 02-02-2022 | 21:00 |
| Avellino | Juve Stabia | 03-02-2022 | 18:00 |
| Potenza | Foggia | 03-02-2022 | 18:00 |
| Farense | Academica | 03-02-2022 | 21:15 |
| Royal Excel Mouscron | Waasland-beveren | 04-02-2022 | 01:00 |
| Lierse Kempenzonen | Deinze | 04-02-2022 | 01:00 |
| KVC Westerlo | Lommel United | 04-02-2022 | 01:00 |
| Excelsior Virton | RWDM | 04-02-2022 | 01:00 |
| FC Heidenheim | Hannover 96 | 04-02-2022 | 18:30 |
| FC Nurnberg | FC Ingolstadt 04 | 04-02-2022 | 18:30 |
| Boulogne | Annecy | 04-02-2022 | 19:00 |
| Chambly Thelle FC | Orleans | 04-02-2022 | 19:00 |
| RED Star FC 93 | Stade Briochin | 04-02-2022 | 19:00 |
| Laval | Bastia-Borgo | 04-02-2022 | 19:00 |
| Sedan | Cholet | 04-02-2022 | 19:00 |
| Chateauroux | Creteil | 04-02-2022 | 19:00 |
| Freiburg II | FC Viktoria Koln | 04-02-2022 | 19:00 |
| Bourg-en-bresse 01 | Avranches | 04-02-2022 | 19:00 |
| Dordrecht | Almere City FC | 04-02-2022 | 20:00 |
| NAC Breda | Roda | 04-02-2022 | 20:00 |
| Telstar | De Graafschap | 04-02-2022 | 20:00 |
| Jong Ajax | Jong AZ | 04-02-2022 | 20:00 |
| Den Bosch | ADO Den Haag | 04-02-2022 | 20:00 |
| Jong PSV | Helmond Sport | 04-02-2022 | 20:00 |
| MVV | VVV Venlo | 04-02-2022 | 20:00 |
| Emmen | FC OSS | 04-02-2022 | 20:00 |
| Hertha Berlin | VfL BOCHUM | 04-02-2022 | 20:30 |
| Marseille | Angers | 04-02-2022 | 21:00 |
| Oostende | OH Leuven | 05-02-2022 | 01:00 |
| Club Brugge KV | Gent | 05-02-2022 | 01:00 |
| Kortrijk | St. Truiden | 05-02-2022 | 01:00 |
| GAP Connah S Quay FC | Cardiff MET | 05-02-2022 | 01:00 |
| Anderlecht | AS Eupen | 05-02-2022 | 01:00 |
| Antwerp | Union St. Gilloise | 05-02-2022 | 01:00 |
| KV Mechelen | Beerschot Wilrijk | 05-02-2022 | 01:00 |
| Charleroi | Seraing United | 05-02-2022 | 01:00 |
| Genk | Zulte Waregem | 05-02-2022 | 01:00 |
| Standard Liege | Cercle Brugge | 05-02-2022 | 01:00 |
| Tuzlaspor | Bal?kesirspor | 05-02-2022 | 11:30 |
| Harrogate Town | Bradford | 05-02-2022 | 14:00 |
| VfL Osnabruck | Türkgücü-Ataspor | 05-02-2022 | 14:00 |
| Verl | Hallescher FC | 05-02-2022 | 14:00 |
| Waldhof Mannheim | Viktoria Berlin | 05-02-2022 | 14:00 |
| Havelse | SV Meppen | 05-02-2022 | 14:00 |
| FC Magdeburg | SV Wehen | 05-02-2022 | 14:00 |
| FSV Zwickau | FC Kaiserslautern | 05-02-2022 | 14:00 |
| Bursaspor | Alt?nordu | 05-02-2022 | 14:00 |
| Noordwijk | Spakenburg | 05-02-2022 | 14:30 |
| Giana Erminio | Juventus U23 | 05-02-2022 | 14:30 |
| Giana Erminio | Juventus U23 | 05-02-2022 | 14:30 |
| Giana Erminio | Juventus U23 | 05-02-2022 | 14:30 |
| Giana Erminio | Juventus U23 | 05-02-2022 | 14:30 |
| Pergolettese | Seregno | 05-02-2022 | 14:30 |
| Giana Erminio | Juventus U23 | 05-02-2022 | 14:30 |
| Giana Erminio | Juventus U23 | 05-02-2022 | 14:30 |
| Giana Erminio | Juventus U23 | 05-02-2022 | 14:30 |
| Mantova | Trento | 05-02-2022 | 14:30 |
| Giana Erminio | Juventus U23 | 05-02-2022 | 14:30 |
| Giana Erminio | Juventus U23 | 05-02-2022 | 14:30 |
| Giana Erminio | Juventus U23 | 05-02-2022 | 14:30 |
| ASWH | SVV Scheveningen | 05-02-2022 | 15:00 |
| Ijsselmeervogels | Volendam II | 05-02-2022 | 15:00 |
| como | Lecce | 05-02-2022 | 15:00 |
| Alessandria | Pisa | 05-02-2022 | 15:00 |
| Cremonese | Monza | 05-02-2022 | 15:00 |
| Pordenone | Spal | 05-02-2022 | 15:00 |
| Ternana | Reggina | 05-02-2022 | 15:00 |
| Ascoli | Perugia | 05-02-2022 | 15:00 |
| Frosinone | Vicenza Virtus | 05-02-2022 | 15:00 |
| Benevento | Parma | 05-02-2022 | 15:00 |
| Nuova Cosenza | Brescia | 05-02-2022 | 15:00 |
| Crotone | Cittadella | 05-02-2022 | 15:00 |
| Katwijk | Rijnsburgse Boys | 05-02-2022 | 15:30 |
| TEC | Kozakken Boys | 05-02-2022 | 15:30 |
| GVVV Veenendaal | Koninklijke HFC | 05-02-2022 | 15:30 |
| FC Koln | SC Freiburg | 05-02-2022 | 15:30 |
| Arminia Bielefeld | Borussia Monchengladbach | 05-02-2022 | 15:30 |
| FSV Mainz 05 | 1899 Hoffenheim | 05-02-2022 | 15:30 |
| VfB Stuttgart | Eintracht Frankfurt | 05-02-2022 | 15:30 |
| FC Augsburg | Union Berlin | 05-02-2022 | 15:30 |
| Chelsea | Plymouth | 05-02-2022 | 16:00 |
| Millwall | QPR | 05-02-2022 | 16:00 |
| Leyton Orient | Colchester | 05-02-2022 | 16:00 |
| Tottenham | Brighton | 05-02-2022 | 16:00 |
| Charlton | AFC Wimbledon | 05-02-2022 | 16:00 |
| Crystal Palace | Hartlepool | 05-02-2022 | 16:00 |
| Sutton Utd | Bristol Rovers | 05-02-2022 | 16:00 |
| Maidenhead | Eastleigh | 05-02-2022 | 16:00 |
| Crawley Town | Stevenage | 05-02-2022 | 16:00 |
| Aldershot Town | Barnet | 05-02-2022 | 16:00 |
| Southend | Boreham Wood | 05-02-2022 | 16:00 |
| Reading | Stoke City | 05-02-2022 | 16:00 |
| Milton Keynes Dons | Lincoln | 05-02-2022 | 16:00 |
| Oxford United | Portsmouth | 05-02-2022 | 16:00 |
| Cambridge United | Luton | 05-02-2022 | 16:00 |
| Cambridge United | Wycombe | 05-02-2022 | 16:00 |
| Ipswich | Gillingham | 05-02-2022 | 16:00 |
| Southampton | Coventry | 05-02-2022 | 16:00 |
| Swindon Town | Exeter City | 05-02-2022 | 16:00 |
| Peterborough | Luton | 05-02-2022 | 16:00 |
| Peterborough | QPR | 05-02-2022 | 16:00 |
| King's Lynn Town | Weymouth | 05-02-2022 | 16:00 |
| Bournemouth | Boreham Wood | 05-02-2022 | 16:00 |
| Forest Green | Newport County | 05-02-2022 | 16:00 |
| Birmingham | Sheffield Utd | 05-02-2022 | 16:00 |
| West Brom | Bournemouth | 05-02-2022 | 16:00 |
| Nottingham Forest | Coventry | 05-02-2022 | 16:00 |
| Nottingham Forest | Leicester | 05-02-2022 | 16:00 |
| Walsall | Northampton | 05-02-2022 | 16:00 |
| Notts County | Grimsby | 05-02-2022 | 16:00 |
| Kidderminster Harriers | West Ham | 05-02-2022 | 16:00 |
| Burton Albion | Sheffield Wednesday | 05-02-2022 | 16:00 |
| Wolves | Norwich | 05-02-2022 | 16:00 |
| Yeovil Town | Solihull Moors | 05-02-2022 | 16:00 |
| Chesterfield | Dagenham & Redbridge | 05-02-2022 | 16:00 |
| Stoke City | Wigan | 05-02-2022 | 16:00 |
| Shrewsbury | Fleetwood Town | 05-02-2022 | 16:00 |
| Rotherham | Accrington ST | 05-02-2022 | 16:00 |
| Scunthorpe | Oldham | 05-02-2022 | 16:00 |
| Barnsley | Cardiff | 05-02-2022 | 16:00 |
| Hull City | Preston | 05-02-2022 | 16:00 |
| Stockport County | Dover | 05-02-2022 | 16:00 |
| Altrincham | Woking | 05-02-2022 | 16:00 |
| Manchester City | Fulham | 05-02-2022 | 16:00 |
| Manchester United | Middlesbrough | 05-02-2022 | 16:00 |
| Swansea | Blackburn | 05-02-2022 | 16:00 |
| Huddersfield | Derby | 05-02-2022 | 16:00 |
| Huddersfield | Barnsley | 05-02-2022 | 16:00 |
| Torquay | Wrexham | 05-02-2022 | 16:00 |
| Salford City | Port Vale | 05-02-2022 | 16:00 |
| FC Halifax Town | Bromley | 05-02-2022 | 16:00 |
| Rochdale | Carlisle | 05-02-2022 | 16:00 |
| Wigan | Crewe | 05-02-2022 | 16:00 |
| Liverpool | Cardiff | 05-02-2022 | 16:00 |
| Everton | Brentford | 05-02-2022 | 16:00 |
| Plymouth | Cheltenham | 05-02-2022 | 16:00 |
| Blackpool | Bristol City | 05-02-2022 | 16:00 |
| Morecambe | Bolton | 05-02-2022 | 16:00 |
| Middlesbrough | Fulham | 05-02-2022 | 16:00 |
| Barrow | Tranmere | 05-02-2022 | 16:00 |
| Hartlepool | Mansfield Town | 05-02-2022 | 16:00 |
| Sunderland | Doncaster | 05-02-2022 | 16:00 |
| Annan Athletic | Stenhousemuir | 05-02-2022 | 16:00 |
| Plymouth | Cheltenham | 05-02-2022 | 16:00 |
| Stranraer | Edinburgh City | 05-02-2022 | 16:00 |
| Ballymena United | Portstewart | 05-02-2022 | 16:00 |
| Coleraine FC | Portadown | 05-02-2022 | 16:00 |
| Newry City AFC | Dundela | 05-02-2022 | 16:00 |
| Queen's University | Glentoran | 05-02-2022 | 16:00 |
| Carrick Rangers | Cliftonville FC | 05-02-2022 | 16:00 |
| Larne | Linfield | 05-02-2022 | 16:00 |
| Ayr Utd | Dunfermline | 05-02-2022 | 16:00 |
| Hibernian | ST Mirren | 05-02-2022 | 16:00 |
| Livingston | Aberdeen | 05-02-2022 | 16:00 |
| Raith Rovers | Hamilton Academical | 05-02-2022 | 16:00 |
| Dungannon Swifts | Annagh United | 05-02-2022 | 16:00 |
| Ballymena United | Portstewart | 05-02-2022 | 16:00 |
| Coleraine FC | Portadown | 05-02-2022 | 16:00 |
| Newry City AFC | Dundela | 05-02-2022 | 16:00 |
| Falkirk | Queen's Park | 05-02-2022 | 16:00 |
| East Fife | Clyde | 05-02-2022 | 16:00 |
| Partick | Queen of the South | 05-02-2022 | 16:00 |
| Kelty Hearts | Elgin City | 05-02-2022 | 16:00 |
| Stirling Albion | Cowdenbeath | 05-02-2022 | 16:00 |
| Dundee | Ross County | 05-02-2022 | 16:00 |
| Arbroath | Kilmarnock | 05-02-2022 | 16:00 |
| ST Johnstone | Dundee Utd | 05-02-2022 | 16:00 |
| Middlesbrough | Fulham | 05-02-2022 | 16:00 |
| Ballymena United | Portstewart | 05-02-2022 | 16:00 |
| Coleraine FC | Portadown | 05-02-2022 | 16:00 |
| Newry City AFC | Dundela | 05-02-2022 | 16:00 |
| Ballinamallard United | Crusaders FC | 05-02-2022 | 16:00 |
| Montrose | Dumbarton | 05-02-2022 | 16:00 |
| Ballymena United | Portstewart | 05-02-2022 | 16:00 |
| Coleraine FC | Portadown | 05-02-2022 | 16:00 |
| Newry City AFC | Dundela | 05-02-2022 | 16:00 |
| Forfar Athletic | Albion Rovers | 05-02-2022 | 16:00 |
| Cove Rangers | Airdrie United | 05-02-2022 | 16:00 |
| Ballymena United | Portstewart | 05-02-2022 | 16:00 |
| Coleraine FC | Portadown | 05-02-2022 | 16:00 |
| Newry City AFC | Dundela | 05-02-2022 | 16:00 |
| Peterhead | Alloa Athletic | 05-02-2022 | 16:00 |
| Inverness CT | Morton | 05-02-2022 | 16:00 |
| Forfar Athletic | Albion Rovers | 05-02-2022 | 16:00 |
| Toulouse | Dijon | 05-02-2022 | 16:00 |
| Wolves | Norwich | 05-02-2022 | 16:00 |
| Utrecht | Cambuur | 05-02-2022 | 16:30 |
| Saint Etienne | Montpellier | 05-02-2022 | 17:00 |
| Denizlispor | Eyüpspor | 05-02-2022 | 17:00 |
| De Treffers | Quick Boys | 05-02-2022 | 18:00 |
| De Treffers | Quick Boys | 05-02-2022 | 18:00 |
| Bayern Munich | RB Leipzig | 05-02-2022 | 18:30 |
| Fortuna Sittard | Heerenveen | 05-02-2022 | 18:45 |
| Quevilly | Grenoble | 05-02-2022 | 20:00 |
| PSV Eindhoven | AZ Alkmaar | 05-02-2022 | 20:00 |
| Guingamp | Auxerre | 05-02-2022 | 20:00 |
| PEC Zwolle | NEC Nijmegen | 05-02-2022 | 20:00 |
| Nancy | Caen | 05-02-2022 | 20:00 |
| Niort | LE Havre | 05-02-2022 | 20:00 |
| Sochaux | Amiens | 05-02-2022 | 20:00 |
| Rodez | Valenciennes | 05-02-2022 | 20:00 |
| Nimes | Dunkerque | 05-02-2022 | 20:00 |
| Bastia | PAU | 05-02-2022 | 20:00 |
| Twente | Vitesse | 05-02-2022 | 21:00 |
| Monaco | Lyon | 05-02-2022 | 21:00 |
| FC Schalke 04 | Jahn Regensburg | 06-02-2022 | 01:00 |
| Werder Bremen | Karlsruher SC | 06-02-2022 | 01:00 |
| SV Sandhausen | Erzgebirge AUE | 06-02-2022 | 01:00 |
| FC St. Pauli | SC Paderborn 07 | 06-02-2022 | 01:00 |
| Juventus | Verona | 06-02-2022 | 01:00 |
| Real Sociedad II | Lugo | 06-02-2022 | 01:00 |
| Athletic Club | Espanyol | 06-02-2022 | 01:00 |
| Amorebieta | Oviedo | 06-02-2022 | 01:00 |
| Inter | AC Milan | 06-02-2022 | 01:00 |
| Atalanta | Cagliari | 06-02-2022 | 01:00 |
| Osasuna | Sevilla | 06-02-2022 | 01:00 |
| Sporting Gijon | Eibar | 06-02-2022 | 01:00 |
| Sampdoria | Sassuolo | 06-02-2022 | 01:00 |
| Huesca | Mirandes | 06-02-2022 | 01:00 |
| Burgos | Alcorcon | 06-02-2022 | 01:00 |
| Girona | Ponferradina | 06-02-2022 | 01:00 |
| Zaragoza | Malaga | 06-02-2022 | 01:00 |
| Barcelona | Atletico Madrid | 06-02-2022 | 01:00 |
| Venezia | Napoli | 06-02-2022 | 01:00 |
| Udinese | Torino | 06-02-2022 | 01:00 |
| Bologna | Empoli | 06-02-2022 | 01:00 |
| Fiorentina | Lazio | 06-02-2022 | 01:00 |
| Celta Vigo | Rayo Vallecano | 06-02-2022 | 01:00 |
| Real Madrid | Granada CF | 06-02-2022 | 01:00 |
| Getafe | Levante | 06-02-2022 | 01:00 |
| Fuenlabrada | Valladolid | 06-02-2022 | 01:00 |
| Guimaraes | SC Braga | 06-02-2022 | 01:00 |
| GIL Vicente | Santa Clara | 06-02-2022 | 01:00 |
| Moreirense | Belenenses | 06-02-2022 | 01:00 |
| Pacos Ferreira | Portimonense | 06-02-2022 | 01:00 |
| Penafiel | Trofense | 06-02-2022 | 01:00 |
| Varzim | Nacional | 06-02-2022 | 01:00 |
| Leixoes | Rio Ave | 06-02-2022 | 01:00 |
| Boavista | Vizela | 06-02-2022 | 01:00 |
| FC Porto B | SC Covilha | 06-02-2022 | 01:00 |
| Arouca | FC Porto | 06-02-2022 | 01:00 |
| Valencia | Real Sociedad | 06-02-2022 | 01:00 |
| Feirense | Farense | 06-02-2022 | 01:00 |
| Mallorca | Cadiz | 06-02-2022 | 01:00 |
| Academico Viseu | Chaves | 06-02-2022 | 01:00 |
| Tondela | Benfica | 06-02-2022 | 01:00 |
| AS Roma | Genoa | 06-02-2022 | 01:00 |
| Elche | Alaves | 06-02-2022 | 01:00 |
| Vilafranquense | Mafra | 06-02-2022 | 01:00 |
| FC Cartagena | Las Palmas | 06-02-2022 | 01:00 |
| Sporting CP | Famalicao | 06-02-2022 | 01:00 |
| Benfica B | Casa Pia | 06-02-2022 | 01:00 |
| Estrela | Academica | 06-02-2022 | 01:00 |
| Real Betis | Villarreal | 06-02-2022 | 01:00 |
| Almeria | Ibiza | 06-02-2022 | 01:00 |
| Penafiel | Trofense | 06-02-2022 | 01:00 |
| Salernitana | Spezia | 06-02-2022 | 01:00 |
| Besiktas | Antalyaspor | 06-02-2022 | 01:00 |
| Maritimo | Estoril | 06-02-2022 | 01:00 |
| Fenerbahce | Istanbul Basaksehir | 06-02-2022 | 01:00 |
| Goztepe | Altay | 06-02-2022 | 01:00 |
| Tenerife | Leganes | 06-02-2022 | 01:00 |
| Konyaspor | Giresunspor | 06-02-2022 | 01:00 |
| Alanyaspor | Galatasaray | 06-02-2022 | 01:00 |
| Kayserispor | Hatayspor | 06-02-2022 | 01:00 |
| Rizespor | Adana Demirspor | 06-02-2022 | 01:00 |
| Erzurum BB | Manisa BBSK | 06-02-2022 | 11:30 |
| Feyenoord | Sparta Rotterdam | 06-02-2022 | 12:15 |
| Lorient | Lens | 06-02-2022 | 13:00 |
| TSV 1860 Munich | Eintracht Braunschweig | 06-02-2022 | 13:00 |
| SV Darmstadt 98 | Hamburger SV | 06-02-2022 | 13:30 |
| Holstein Kiel | Fortuna Dusseldorf | 06-02-2022 | 13:30 |
| Dynamo Dresden | Hansa Rostock | 06-02-2022 | 13:30 |
| MSV Duisburg | Borussia Dortmund II | 06-02-2022 | 14:00 |
| Menemen Belediyespor | Adanaspor | 06-02-2022 | 14:00 |
| AFC Amsterdam | Sparta Rotterdam II | 06-02-2022 | 14:30 |
| Willem II | Waalwijk | 06-02-2022 | 14:30 |
| Groningen | GO Ahead Eagles | 06-02-2022 | 14:30 |
| Motherwell | Celtic | 06-02-2022 | 14:30 |
| Fiorenzuola | Padova | 06-02-2022 | 14:30 |
| Fiorenzuola | Padova | 06-02-2022 | 14:30 |
| Pro Patria | Lecco | 06-02-2022 | 14:30 |
| PRO Vercelli | Virtus Verona | 06-02-2022 | 14:30 |
| Renate | Sudtirol | 06-02-2022 | 14:30 |
| Fiorenzuola | Padova | 06-02-2022 | 14:30 |
| Fiorenzuola | Padova | 06-02-2022 | 14:30 |
| Fiorenzuola | Padova | 06-02-2022 | 14:30 |
| Feralpisalo | Albinoleffe | 06-02-2022 | 14:30 |
| Fiorenzuola | Padova | 06-02-2022 | 14:30 |
| Fiorenzuola | Padova | 06-02-2022 | 14:30 |
| Legnago Salus | Piacenza | 06-02-2022 | 14:30 |
| Carrarese | Reggiana | 06-02-2022 | 14:30 |
| Pontedera | Imolese | 06-02-2022 | 14:30 |
| Fiorenzuola | Padova | 06-02-2022 | 14:30 |
| Triestina | Pro Sesto | 06-02-2022 | 14:30 |
| Robur Siena | Montevarchi Calcio | 06-02-2022 | 14:30 |
| Vis Pesaro | Viterbese | 06-02-2022 | 14:30 |
| Grosseto | Fermana | 06-02-2022 | 14:30 |
| Fiorenzuola | Padova | 06-02-2022 | 14:30 |
| Ancona | Pistoiese | 06-02-2022 | 14:30 |
| Olbia | Virtus Entella | 06-02-2022 | 14:30 |
| Teramo | Lucchese | 06-02-2022 | 14:30 |
| Fiorenzuola | Padova | 06-02-2022 | 14:30 |
| Pescara | Gubbio | 06-02-2022 | 14:30 |
| Reims | Bordeaux | 06-02-2022 | 15:00 |
| Estac Troyes | Metz | 06-02-2022 | 15:00 |
| Strasbourg | Nantes | 06-02-2022 | 15:00 |
| Nice | Clermont Foot | 06-02-2022 | 15:00 |
| Borussia Dortmund | Bayer Leverkusen | 06-02-2022 | 15:30 |
| Ajax | Heracles | 06-02-2022 | 16:45 |
| Rennes | Stade Brestois 29 | 06-02-2022 | 17:00 |
| Rangers | Heart OF Midlothian | 06-02-2022 | 17:00 |
| Genclerbirligi | Ankaragucu | 06-02-2022 | 17:00 |
| VfL Wolfsburg | SpVgg Greuther Furth | 06-02-2022 | 17:30 |
| Monterosi | Taranto | 06-02-2022 | 17:30 |
| Turris | Catania | 06-02-2022 | 17:30 |
| Foggia | Fidelis Andria | 06-02-2022 | 17:30 |
| Juve Stabia | Latina | 06-02-2022 | 17:30 |
| AZ Picerno | SS Monopoli | 06-02-2022 | 17:30 |
| Bari | Messina | 06-02-2022 | 17:30 |
| Virtus Francavilla | Potenza | 06-02-2022 | 17:30 |
| Vibonese | Paganese | 06-02-2022 | 17:30 |
| Catanzaro | Avellino | 06-02-2022 | 17:30 |
| Lille | Paris Saint Germain | 06-02-2022 | 20:45 |
| Lille | Paris Saint Germain | 06-02-2022 | 20:45 |
| Kocaelispor | Boluspor | 07-02-2022 | 18:00 |
| FC Saarbrucken | FC Wurzburger Kickers | 07-02-2022 | 19:00 |
| Jong Ajax | Jong PSV | 07-02-2022 | 20:00 |
| FC Eindhoven | Excelsior | 07-02-2022 | 20:00 |
| Roda | FC Volendam | 07-02-2022 | 20:00 |
| Roda | FC Volendam | 07-02-2022 | 20:00 |
| Concarneau | Villefranche | 07-02-2022 | 20:45 |
| Modena | Cesena | 07-02-2022 | 21:00 |
| Paris FC | Ajaccio | 07-02-2022 | 21:45 |
| Fulham | Millwall | 08-02-2022 | 20:45 |
| West Ham | Watford | 08-02-2022 | 20:45 |
| AFC Wimbledon | Rotherham | 08-02-2022 | 20:45 |
| Sutton Utd | Salford City | 08-02-2022 | 20:45 |
| Wealdstone | Yeovil Town | 08-02-2022 | 20:45 |
| Stevenage | Bradford | 08-02-2022 | 20:45 |
| Luton | Barnsley | 08-02-2022 | 20:45 |
| Wycombe | Shrewsbury | 08-02-2022 | 20:45 |
| Gillingham | Cambridge United | 08-02-2022 | 20:45 |
| Newcastle | Everton | 08-02-2022 | 20:45 |
| Northampton | Newport County | 08-02-2022 | 20:45 |
| Portsmouth | Burton Albion | 08-02-2022 | 20:45 |
| Cheltenham | Sunderland | 08-02-2022 | 20:45 |
| Forest Green | Rochdale | 08-02-2022 | 20:45 |
| Coventry | Blackpool | 08-02-2022 | 20:45 |
| Derby | Hull City | 08-02-2022 | 20:45 |
| Lincoln | Morecambe | 08-02-2022 | 20:45 |
| Mansfield Town | Colchester | 08-02-2022 | 20:45 |
| Cardiff | Peterborough | 08-02-2022 | 20:45 |
| Stoke City | Swansea | 08-02-2022 | 20:45 |
| Sheffield Wednesday | Wigan | 08-02-2022 | 20:45 |
| Doncaster | Ipswich | 08-02-2022 | 20:45 |
| Scunthorpe | Walsall | 08-02-2022 | 20:45 |
| Crewe | Plymouth | 08-02-2022 | 20:45 |
| Stockport County | Chesterfield | 08-02-2022 | 20:45 |
| Exeter City | Leyton Orient | 08-02-2022 | 20:45 |
| Oldham | Bristol Rovers | 08-02-2022 | 20:45 |
| Tranmere | Swindon Town | 08-02-2022 | 20:45 |
| Harrogate Town | Crawley Town | 08-02-2022 | 20:45 |
| Accrington ST | Oxford United | 08-02-2022 | 20:45 |
| Fleetwood Town | Milton Keynes Dons | 08-02-2022 | 20:45 |
| Hartlepool | Barrow | 08-02-2022 | 20:45 |
| Newcastle | Everton | 08-02-2022 | 20:45 |
| Carlisle | Port Vale | 08-02-2022 | 20:45 |
| Coleraine FC | Dungannon Swifts | 08-02-2022 | 20:45 |
| Linfield | Larne | 08-02-2022 | 20:45 |
| Crusaders FC | Ballymena United | 08-02-2022 | 20:45 |
| Carrick Rangers | Cliftonville FC | 08-02-2022 | 20:45 |
| Glenavon FC | Warrenpoint Town | 08-02-2022 | 20:45 |
| Portadown | Glentoran | 08-02-2022 | 20:45 |
| Coleraine FC | Dungannon Swifts | 08-02-2022 | 20:45 |
| Coleraine FC | Dungannon Swifts | 08-02-2022 | 20:45 |
| Coleraine FC | Dungannon Swifts | 08-02-2022 | 20:45 |
| Coleraine FC | Dungannon Swifts | 08-02-2022 | 20:45 |
| Bolton | Charlton | 08-02-2022 | 21:00 |
| Burnley | Manchester United | 08-02-2022 | 21:00 |
| Virtus Verona | Sudtirol | 09-02-2022 | 18:00 |
| QPR | Middlesbrough | 09-02-2022 | 20:45 |
| Tottenham | Southampton | 09-02-2022 | 20:45 |
| Bournemouth | Birmingham | 09-02-2022 | 20:45 |
| Norwich | Crystal Palace | 09-02-2022 | 20:45 |
| Bristol City | Reading | 09-02-2022 | 20:45 |
| Sheffield Utd | West Brom | 09-02-2022 | 20:45 |
| Manchester City | Brentford | 09-02-2022 | 20:45 |
| Blackburn | Nottingham Forest | 09-02-2022 | 20:45 |
| Preston | Huddersfield | 09-02-2022 | 20:45 |
| Heart OF Midlothian | Dundee | 09-02-2022 | 20:45 |
| Kilmarnock | Ayr Utd | 09-02-2022 | 20:45 |
| Rangers | Hibernian | 09-02-2022 | 20:45 |
| ST Mirren | ST Johnstone | 09-02-2022 | 20:45 |
| Dundee Utd | Motherwell | 09-02-2022 | 20:45 |
| Aberdeen | Celtic | 09-02-2022 | 20:45 |
| Ross County | Livingston | 09-02-2022 | 20:45 |
| Aston Villa | Leeds | 09-02-2022 | 21:00 |
| Chaves | Rio Ave | 10-02-2022 | 19:00 |
| Wolves | Arsenal | 10-02-2022 | 20:45 |
| Liverpool | Leicester | 10-02-2022 | 20:45 |
| Wolves | Arsenal | 10-02-2022 | 20:45 |
| Waasland-beveren | Lierse Kempenzonen | 11-02-2022 | 01:00 |
| RWDM | Deinze | 11-02-2022 | 01:00 |
| Avranches | Sedan | 11-02-2022 | 01:00 |
| KVC Westerlo | Royal Excel Mouscron | 11-02-2022 | 01:00 |
| Creteil | Sète | 11-02-2022 | 01:00 |
| Lommel United | Excelsior Virton | 11-02-2022 | 01:00 |
| Stade Briochin | Chateauroux | 11-02-2022 | 01:00 |
| Le Mans | Bourg-en-bresse 01 | 11-02-2022 | 01:00 |
| Orleans | RED Star FC 93 | 11-02-2022 | 01:00 |
| Cholet | Laval | 11-02-2022 | 01:00 |
| Annecy | Chambly Thelle FC | 11-02-2022 | 01:00 |
| Villefranche | Boulogne | 11-02-2022 | 01:00 |
| Annecy | Chambly Thelle FC | 11-02-2022 | 01:00 |
| Annecy | Chambly Thelle FC | 11-02-2022 | 01:00 |
| Bastia-Borgo | Concarneau | 11-02-2022 | 01:00 |
| Hansa Rostock | Werder Bremen | 11-02-2022 | 18:30 |
| Erzgebirge AUE | Holstein Kiel | 11-02-2022 | 18:30 |
| Hallescher FC | FSV Zwickau | 11-02-2022 | 19:00 |
| Excelsior | Jong Ajax | 11-02-2022 | 20:00 |
| ADO Den Haag | MVV | 11-02-2022 | 20:00 |
| Almere City FC | Emmen | 11-02-2022 | 20:00 |
| FC OSS | FC Eindhoven | 11-02-2022 | 20:00 |
| Helmond Sport | Telstar | 11-02-2022 | 20:00 |
| De Graafschap | Dordrecht | 11-02-2022 | 20:00 |
| Heracles | Utrecht | 11-02-2022 | 20:00 |
| Taffs Well | llanelli AFC | 11-02-2022 | 20:30 |
| Goytre United | Port Talbot Town | 11-02-2022 | 20:30 |
| Briton Ferry | Carmarthen Town | 11-02-2022 | 20:30 |
| Colwyn Bay | Buckley Town | 11-02-2022 | 20:30 |
| Llangefni Town | Bangor City | 11-02-2022 | 20:30 |
| RB Leipzig | FC Koln | 11-02-2022 | 20:30 |
| RB Leipzig | FC Koln | 11-02-2022 | 20:30 |
| Glentoran | Linfield | 11-02-2022 | 20:45 |
| Glentoran | Linfield | 11-02-2022 | 20:45 |
| Glentoran | Linfield | 11-02-2022 | 20:45 |
| Edinburgh City | Stirling Albion | 11-02-2022 | 20:45 |
| Dunkerque | Rodez | 12-02-2022 | 01:00 |
| LE Havre | Bastia | 12-02-2022 | 01:00 |
| Club Brugge KV | Charleroi | 12-02-2022 | 01:00 |
| Amiens | Niort | 12-02-2022 | 01:00 |
| Zulte Waregem | Anderlecht | 12-02-2022 | 01:00 |
| Caen | Nimes | 12-02-2022 | 01:00 |
| Valenciennes | Toulouse | 12-02-2022 | 01:00 |
| Beerschot Wilrijk | Kortrijk | 12-02-2022 | 01:00 |
| Union St. Gilloise | St. Truiden | 12-02-2022 | 01:00 |
| KV Mechelen | Oostende | 12-02-2022 | 01:00 |
| OH Leuven | Cercle Brugge | 12-02-2022 | 01:00 |
| Paris FC | Quevilly | 12-02-2022 | 01:00 |
| Genk | Standard Liege | 12-02-2022 | 01:00 |
| Seraing United | Antwerp | 12-02-2022 | 01:00 |
| AS Eupen | Gent | 12-02-2022 | 01:00 |
| Auxerre | Nancy | 12-02-2022 | 01:00 |
| Dijon | PAU | 12-02-2022 | 01:00 |
| Grenoble | Sochaux | 12-02-2022 | 01:00 |
| Ajaccio | Guingamp | 12-02-2022 | 01:00 |
| Manchester United | Southampton | 12-02-2022 | 13:30 |
| SV Meppen | TSV 1860 Munich | 12-02-2022 | 14:00 |
| Borussia Dortmund II | Havelse | 12-02-2022 | 14:00 |
| FC Kaiserslautern | FC Magdeburg | 12-02-2022 | 14:00 |
| FC Wurzburger Kickers | MSV Duisburg | 12-02-2022 | 14:00 |
| Eintracht Braunschweig | Freiburg II | 12-02-2022 | 14:00 |
| Undy Athletic | Risca United | 12-02-2022 | 15:00 |
| Undy Athletic | Risca United | 12-02-2022 | 15:00 |
| Cwmbran Celtic | Afan Lido | 12-02-2022 | 15:00 |
| Llantwit Major | Pontypridd Town | 12-02-2022 | 15:00 |
| Quick Boys | ASWH | 12-02-2022 | 15:00 |
| Kozakken Boys | AFC Amsterdam | 12-02-2022 | 15:00 |
| Volendam II | GVVV Veenendaal | 12-02-2022 | 15:00 |
| Spakenburg | HHC | 12-02-2022 | 15:00 |
| Cwmbran Celtic | Afan Lido | 12-02-2022 | 15:00 |
| Monza | Spal | 12-02-2022 | 15:00 |
| Brescia | Alessandria | 12-02-2022 | 15:00 |
| Parma | Pordenone | 12-02-2022 | 15:00 |
| Vicenza Virtus | Nuova Cosenza | 12-02-2022 | 15:00 |
| Cittadella | Cremonese | 12-02-2022 | 15:00 |
| Pisa | Ternana | 12-02-2022 | 15:00 |
| Perugia | Frosinone | 12-02-2022 | 15:00 |
| Ascoli | como | 12-02-2022 | 15:00 |
| Lecce | Benevento | 12-02-2022 | 15:00 |
| Reggina | Crotone | 12-02-2022 | 15:00 |
| Cambrian & Clydach | Ammanford AFC | 12-02-2022 | 15:30 |
| Guilsfield | Ruthin Town | 12-02-2022 | 15:30 |
| Llanidloes Town | Prestatyn Town | 12-02-2022 | 15:30 |
| Llanrhaeadr | Gresford Athletic | 12-02-2022 | 15:30 |
| Swansea University | Trefelin | 12-02-2022 | 15:30 |
| Penrhyncoch | Airbus UK | 12-02-2022 | 15:30 |
| Llanidloes Town | Prestatyn Town | 12-02-2022 | 15:30 |
| Sparta Rotterdam II | Ijsselmeervogels | 12-02-2022 | 15:30 |
| Conwy Borough | Llandudno | 12-02-2022 | 15:30 |
| Rijnsburgse Boys | TEC | 12-02-2022 | 15:30 |
| Koninklijke HFC | Excelsior Maassluis | 12-02-2022 | 15:30 |
| Llanidloes Town | Prestatyn Town | 12-02-2022 | 15:30 |
| Holyhead Hotspur | Holywell | 12-02-2022 | 15:30 |
| Borussia Monchengladbach | FC Augsburg | 12-02-2022 | 15:30 |
| Llanidloes Town | Prestatyn Town | 12-02-2022 | 15:30 |
| VfL BOCHUM | Bayern Munich | 12-02-2022 | 15:30 |
| Eintracht Frankfurt | VfL Wolfsburg | 12-02-2022 | 15:30 |
| SC Freiburg | FSV Mainz 05 | 12-02-2022 | 15:30 |
| Llanidloes Town | Prestatyn Town | 12-02-2022 | 15:30 |
| SpVgg Greuther Furth | Hertha Berlin | 12-02-2022 | 15:30 |
| Chelsea | Arsenal | 12-02-2022 | 16:00 |
| Millwall | Cardiff | 12-02-2022 | 16:00 |
| Leyton Orient | Salford City | 12-02-2022 | 16:00 |
| Brentford | Crystal Palace | 12-02-2022 | 16:00 |
| AFC Wimbledon | Sunderland | 12-02-2022 | 16:00 |
| Barnet | Wealdstone | 12-02-2022 | 16:00 |
| Bromley | Stockport County | 12-02-2022 | 16:00 |
| Sutton Utd | Forest Green | 12-02-2022 | 16:00 |
| Boreham Wood | Altrincham | 12-02-2022 | 16:00 |
| Dagenham & Redbridge | Maidenhead | 12-02-2022 | 16:00 |
| Watford | Brighton | 12-02-2022 | 16:00 |
| Woking | Southend | 12-02-2022 | 16:00 |
| Crawley Town | Hartlepool | 12-02-2022 | 16:00 |
| Reading | Coventry | 12-02-2022 | 16:00 |
| Milton Keynes Dons | Ipswich | 12-02-2022 | 16:00 |
| Oxford United | Bolton | 12-02-2022 | 16:00 |
| Colchester | Carlisle | 12-02-2022 | 16:00 |
| Portsmouth | Doncaster | 12-02-2022 | 16:00 |
| Eastleigh | Yeovil Town | 12-02-2022 | 16:00 |
| Dover | Torquay | 12-02-2022 | 16:00 |
| Swindon Town | Scunthorpe | 12-02-2022 | 16:00 |
| Peterborough | Preston | 12-02-2022 | 16:00 |
| Cheltenham | Fleetwood Town | 12-02-2022 | 16:00 |
| Solihull Moors | Notts County | 12-02-2022 | 16:00 |
| Birmingham | Luton | 12-02-2022 | 16:00 |
| West Brom | Blackburn | 12-02-2022 | 16:00 |
| Bristol Rovers | Mansfield Town | 12-02-2022 | 16:00 |
| Nottingham Forest | Stoke City | 12-02-2022 | 16:00 |
| Walsall | Tranmere | 12-02-2022 | 16:00 |
| Burton Albion | Cambridge United | 12-02-2022 | 16:00 |
| Lincoln | Wycombe | 12-02-2022 | 16:00 |
| Weymouth | Chesterfield | 12-02-2022 | 16:00 |
| Newport County | Oldham | 12-02-2022 | 16:00 |
| Port Vale | Northampton | 12-02-2022 | 16:00 |
| Grimsby | Aldershot Town | 12-02-2022 | 16:00 |
| Sheffield Wednesday | Rotherham | 12-02-2022 | 16:00 |
| Barnsley | QPR | 12-02-2022 | 16:00 |
| Hull City | Fulham | 12-02-2022 | 16:00 |
| Wrexham | King's Lynn Town | 12-02-2022 | 16:00 |
| Huddersfield | Sheffield Utd | 12-02-2022 | 16:00 |
| Rochdale | Harrogate Town | 12-02-2022 | 16:00 |
| Bradford | Exeter City | 12-02-2022 | 16:00 |
| Watford | Brighton | 12-02-2022 | 16:00 |
| Wigan | Charlton | 12-02-2022 | 16:00 |
| Everton | Leeds | 12-02-2022 | 16:00 |
| Cowdenbeath | Forfar Athletic | 12-02-2022 | 16:00 |
| Accrington ST | Crewe | 12-02-2022 | 16:00 |
| Plymouth | Shrewsbury | 12-02-2022 | 16:00 |
| Blackpool | Bournemouth | 12-02-2022 | 16:00 |
| Morecambe | Gillingham | 12-02-2022 | 16:00 |
| Middlesbrough | Derby | 12-02-2022 | 16:00 |
| Barrow | Stevenage | 12-02-2022 | 16:00 |
| Boreham Wood | Altrincham | 12-02-2022 | 16:00 |
| Plymouth | Shrewsbury | 12-02-2022 | 16:00 |
| Warrenpoint Town | Carrick Rangers | 12-02-2022 | 16:00 |
| Ballymena United | Dungannon Swifts | 12-02-2022 | 16:00 |
| Knockbreda | Annagh United | 12-02-2022 | 16:00 |
| Dundela | Queen's University | 12-02-2022 | 16:00 |
| H&W Welders | Ballyclare Comrades | 12-02-2022 | 16:00 |
| Cliftonville FC | Coleraine FC | 12-02-2022 | 16:00 |
| Glenavon FC | Portadown | 12-02-2022 | 16:00 |
| Larne | Crusaders FC | 12-02-2022 | 16:00 |
| Airdrie United | Montrose | 12-02-2022 | 16:00 |
| Albion Rovers | Annan Athletic | 12-02-2022 | 16:00 |
| Queen's Park | Cove Rangers | 12-02-2022 | 16:00 |
| Ballymena United | Dungannon Swifts | 12-02-2022 | 16:00 |
| Falkirk | Peterhead | 12-02-2022 | 16:00 |
| Cowdenbeath | Forfar Athletic | 12-02-2022 | 16:00 |
| Clyde | Dumbarton | 12-02-2022 | 16:00 |
| Stenhousemuir | Kelty Hearts | 12-02-2022 | 16:00 |
| Alloa Athletic | East Fife | 12-02-2022 | 16:00 |
| Middlesbrough | Derby | 12-02-2022 | 16:00 |
| Ballymena United | Dungannon Swifts | 12-02-2022 | 16:00 |
| Ballinamallard United | Ards | 12-02-2022 | 16:00 |
| Ballymena United | Dungannon Swifts | 12-02-2022 | 16:00 |
| Dergview | Newry City AFC | 12-02-2022 | 16:00 |
| Institute | Loughgall | 12-02-2022 | 16:00 |
| Ballymena United | Dungannon Swifts | 12-02-2022 | 16:00 |
| Elgin City | Stranraer | 12-02-2022 | 16:00 |
| GO Ahead Eagles | AZ Alkmaar | 12-02-2022 | 16:30 |
| Latina | Turris | 12-02-2022 | 17:30 |
| Avellino | Monterosi | 12-02-2022 | 17:30 |
| SS Monopoli | Bari | 12-02-2022 | 17:30 |
| De Treffers | Noordwijk | 12-02-2022 | 18:00 |
| De Treffers | Noordwijk | 12-02-2022 | 18:00 |
| Cardiff MET | The New Saints | 12-02-2022 | 18:15 |
| Barry Town | Caernarfon Town | 12-02-2022 | 18:15 |
| Penybont | Flint Town United | 12-02-2022 | 18:15 |
| Newtown AFC | GAP Connah S Quay FC | 12-02-2022 | 18:15 |
| Cefn Druids AFC | Haverfordwest County AFC | 12-02-2022 | 18:15 |
| Bala Town | Aberystwyth Town | 12-02-2022 | 18:15 |
| Norwich | Manchester City | 12-02-2022 | 18:30 |
| Bayer Leverkusen | VfB Stuttgart | 12-02-2022 | 18:30 |
| Groningen | Fortuna Sittard | 12-02-2022 | 18:45 |
| Vitesse | PSV Eindhoven | 12-02-2022 | 20:00 |
| Lens | Bordeaux | 13-02-2022 | 01:00 |
| Paris Saint Germain | Rennes | 13-02-2022 | 01:00 |
| Cambuur | PEC Zwolle | 13-02-2022 | 01:00 |
| Angers | Strasbourg | 13-02-2022 | 01:00 |
| Stade Brestois 29 | Estac Troyes | 13-02-2022 | 01:00 |
| Nantes | Reims | 13-02-2022 | 01:00 |
| Metz | Marseille | 13-02-2022 | 01:00 |
| SC Paderborn 07 | Dynamo Dresden | 13-02-2022 | 01:00 |
| Karlsruher SC | FC Nurnberg | 13-02-2022 | 01:00 |
| Clermont Foot | Saint Etienne | 13-02-2022 | 01:00 |
| Hamburger SV | FC Heidenheim | 13-02-2022 | 01:00 |
| Lyon | Nice | 13-02-2022 | 01:00 |
| Jahn Regensburg | FC St. Pauli | 13-02-2022 | 01:00 |
| Torino | Venezia | 13-02-2022 | 01:00 |
| Real Sociedad | Granada CF | 13-02-2022 | 01:00 |
| Montpellier | Lille | 13-02-2022 | 01:00 |
| Eibar | Fuenlabrada | 13-02-2022 | 01:00 |
| AC Milan | Sampdoria | 13-02-2022 | 01:00 |
| Atalanta | Juventus | 13-02-2022 | 01:00 |
| Alaves | Valencia | 13-02-2022 | 01:00 |
| Oviedo | Huesca | 13-02-2022 | 01:00 |
| Mirandes | Sporting Gijon | 13-02-2022 | 01:00 |
| Monaco | Lorient | 13-02-2022 | 01:00 |
| Genoa | Salernitana | 13-02-2022 | 01:00 |
| Verona | Udinese | 13-02-2022 | 01:00 |
| Lugo | Amorebieta | 13-02-2022 | 01:00 |
| Sassuolo | AS Roma | 13-02-2022 | 01:00 |
| Spezia | Fiorentina | 13-02-2022 | 01:00 |
| Ponferradina | Real Sociedad II | 13-02-2022 | 01:00 |
| Espanyol | Barcelona | 13-02-2022 | 01:00 |
| Valladolid | Girona | 13-02-2022 | 01:00 |
| Empoli | Cagliari | 13-02-2022 | 01:00 |
| Chaves | Vilafranquense | 13-02-2022 | 01:00 |
| Atletico Madrid | Getafe | 13-02-2022 | 01:00 |
| Rayo Vallecano | Osasuna | 13-02-2022 | 01:00 |
| Leganes | Zaragoza | 13-02-2022 | 01:00 |
| SC Braga | Pacos Ferreira | 13-02-2022 | 01:00 |
| Alcorcon | Tenerife | 13-02-2022 | 01:00 |
| Villarreal | Real Madrid | 13-02-2022 | 01:00 |
| Vizela | GIL Vicente | 13-02-2022 | 01:00 |
| Famalicao | Moreirense | 13-02-2022 | 01:00 |
| Varzim | Leixoes | 13-02-2022 | 01:00 |
| Rio Ave | Estrela | 13-02-2022 | 01:00 |
| FC Porto | Sporting CP | 13-02-2022 | 01:00 |
| Arouca | Maritimo | 13-02-2022 | 01:00 |
| Levante | Real Betis | 13-02-2022 | 01:00 |
| Mallorca | Athletic Club | 13-02-2022 | 01:00 |
| SC Covilha | Benfica B | 13-02-2022 | 01:00 |
| Ibiza | FC Cartagena | 13-02-2022 | 01:00 |
| Academica | Feirense | 13-02-2022 | 01:00 |
| Lazio | Bologna | 13-02-2022 | 01:00 |
| Mafra | FC Porto B | 13-02-2022 | 01:00 |
| Casa Pia | Trofense | 13-02-2022 | 01:00 |
| Belenenses | Guimaraes | 13-02-2022 | 01:00 |
| Estoril | Tondela | 13-02-2022 | 01:00 |
| Napoli | Inter | 13-02-2022 | 01:00 |
| Sevilla | Elche | 13-02-2022 | 01:00 |
| Malaga | Almeria | 13-02-2022 | 01:00 |
| Farense | Academico Viseu | 13-02-2022 | 01:00 |
| Portimonense | Boavista | 13-02-2022 | 01:00 |
| Cadiz | Celta Vigo | 13-02-2022 | 01:00 |
| Istanbul Basaksehir | Gazi?ehir Gaziantep | 13-02-2022 | 01:00 |
| Galatasaray | Kayserispor | 13-02-2022 | 01:00 |
| Nacional | Penafiel | 13-02-2022 | 01:00 |
| Kasimpasa | Alanyaspor | 13-02-2022 | 01:00 |
| Altay | Rizespor | 13-02-2022 | 01:00 |
| Manisa BBSK | Menemen Belediyespor | 13-02-2022 | 01:00 |
| Boluspor | Keçiörengücü | 13-02-2022 | 01:00 |
| Ankaragucu | ?stanbulspor | 13-02-2022 | 01:00 |
| Las Palmas | Burgos | 13-02-2022 | 01:00 |
| Antalyaspor | Fatih Karagümrük | 13-02-2022 | 01:00 |
| Samsunspor | Bursaspor | 13-02-2022 | 01:00 |
| Sivasspor | Yeni Malatyaspor | 13-02-2022 | 01:00 |
| Giresunspor | Fenerbahce | 13-02-2022 | 01:00 |
| Adana Demirspor | Besiktas | 13-02-2022 | 01:00 |
| Adanaspor | Denizlispor | 13-02-2022 | 01:00 |
| Hatayspor | Goztepe | 13-02-2022 | 01:00 |
| Sparta Rotterdam | Willem II | 13-02-2022 | 12:15 |
| NAC Breda | Den Bosch | 13-02-2022 | 12:15 |
| Viktoria Berlin | Verl | 13-02-2022 | 13:00 |
| Fortuna Dusseldorf | FC Schalke 04 | 13-02-2022 | 13:30 |
| Hannover 96 | SV Darmstadt 98 | 13-02-2022 | 13:30 |
| FC Ingolstadt 04 | SV Sandhausen | 13-02-2022 | 13:30 |
| Swansea | Bristol City | 13-02-2022 | 14:00 |
| SV Wehen | FC Saarbrucken | 13-02-2022 | 14:00 |
| Waalwijk | Feyenoord | 13-02-2022 | 14:30 |
| VVV Venlo | Roda | 13-02-2022 | 14:30 |
| Heerenveen | NEC Nijmegen | 13-02-2022 | 14:30 |
| Albinoleffe | Triestina | 13-02-2022 | 14:30 |
| Albinoleffe | Triestina | 13-02-2022 | 14:30 |
| Lecco | Fiorenzuola | 13-02-2022 | 14:30 |
| Seregno | Padova | 13-02-2022 | 14:30 |
| Pro Sesto | Feralpisalo | 13-02-2022 | 14:30 |
| Albinoleffe | Triestina | 13-02-2022 | 14:30 |
| Juventus U23 | Mantova | 13-02-2022 | 14:30 |
| Albinoleffe | Triestina | 13-02-2022 | 14:30 |
| Sudtirol | PRO Vercelli | 13-02-2022 | 14:30 |
| Albinoleffe | Triestina | 13-02-2022 | 14:30 |
| Piacenza | Pergolettese | 13-02-2022 | 14:30 |
| Albinoleffe | Triestina | 13-02-2022 | 14:30 |
| Albinoleffe | Triestina | 13-02-2022 | 14:30 |
| Virtus Verona | Pro Patria | 13-02-2022 | 14:30 |
| Legnago Salus | Giana Erminio | 13-02-2022 | 14:30 |
| Albinoleffe | Triestina | 13-02-2022 | 14:30 |
| Albinoleffe | Triestina | 13-02-2022 | 14:30 |
| Albinoleffe | Triestina | 13-02-2022 | 14:30 |
| Tottenham | Wolves | 13-02-2022 | 15:00 |
| Newcastle | Aston Villa | 13-02-2022 | 15:00 |
| Burnley | Liverpool | 13-02-2022 | 15:00 |
| Newcastle | Aston Villa | 13-02-2022 | 15:00 |
| Union Berlin | Borussia Dortmund | 13-02-2022 | 15:30 |
| Ajax | Twente | 13-02-2022 | 16:45 |
| Leicester | West Ham | 13-02-2022 | 17:30 |
| 1899 Hoffenheim | Arminia Bielefeld | 13-02-2022 | 17:30 |
| Virtus Entella | Pontedera | 13-02-2022 | 17:30 |
| Lucchese | Modena | 13-02-2022 | 17:30 |
| Pistoiese | Robur Siena | 13-02-2022 | 17:30 |
| Imolese | Ancona | 13-02-2022 | 17:30 |
| Cesena | Grosseto | 13-02-2022 | 17:30 |
| Montevarchi Calcio | Carrarese | 13-02-2022 | 17:30 |
| Gubbio | Olbia | 13-02-2022 | 17:30 |
| Viterbese | Teramo | 13-02-2022 | 17:30 |
| Fermana | Vis Pesaro | 13-02-2022 | 17:30 |
| Paganese | Città di Campobasso | 13-02-2022 | 17:30 |
| Fidelis Andria | Catanzaro | 13-02-2022 | 17:30 |
| Potenza | Vibonese | 13-02-2022 | 17:30 |
| Taranto | Virtus Francavilla | 13-02-2022 | 17:30 |
| Palermo | Juve Stabia | 13-02-2022 | 17:30 |
| Messina | Foggia | 13-02-2022 | 17:30 |
| Catania | AZ Picerno | 13-02-2022 | 17:30 |
| FC Viktoria Koln | VfL Osnabruck | 14-02-2022 | 19:00 |
| Jong PSV | Jong Utrecht | 14-02-2022 | 20:00 |
| Reggiana | Pescara | 14-02-2022 | 21:00 |
| Alessandria | Lecce | 15-02-2022 | 15:00 |
| Cremonese | Parma | 15-02-2022 | 15:00 |
| Spal | Reggina | 15-02-2022 | 15:00 |
| Pordenone | Cittadella | 15-02-2022 | 15:00 |
| Pisa | Vicenza Virtus | 15-02-2022 | 15:00 |
| Ternana | Monza | 15-02-2022 | 15:00 |
| Frosinone | como | 15-02-2022 | 15:00 |
| Benevento | Ascoli | 15-02-2022 | 15:00 |
| Nuova Cosenza | Perugia | 15-02-2022 | 15:00 |
| Crotone | Brescia | 15-02-2022 | 15:00 |
| Juve Stabia | Catania | 15-02-2022 | 18:00 |
| Catanzaro | Paganese | 15-02-2022 | 18:00 |
| Peterborough | Reading | 15-02-2022 | 20:45 |
| Burton Albion | Bolton | 15-02-2022 | 20:45 |
| Lincoln | Doncaster | 15-02-2022 | 20:45 |
| Sheffield Wednesday | Accrington ST | 15-02-2022 | 20:45 |
| Exeter City | Harrogate Town | 15-02-2022 | 20:45 |
| Hartlepool | Tranmere | 15-02-2022 | 20:45 |
| Paris Saint Germain | Real Madrid | 15-02-2022 | 21:00 |
| Sporting CP | Manchester City | 15-02-2022 | 21:00 |
| Menemen Belediyespor | Ankaragucu | 16-02-2022 | 01:00 |
| Bursaspor | Tuzlaspor | 16-02-2022 | 01:00 |
| Denizlispor | Alt?nordu | 16-02-2022 | 01:00 |
| Genclerbirligi | Samsunspor | 16-02-2022 | 01:00 |
| Erzurum BB | Eyüpspor | 16-02-2022 | 01:00 |
| Giana Erminio | Sudtirol | 16-02-2022 | 18:00 |
| Fiorenzuola | Trento | 16-02-2022 | 18:00 |
| Giana Erminio | Sudtirol | 16-02-2022 | 18:00 |
| Fiorenzuola | Trento | 16-02-2022 | 18:00 |
| Pro Patria | Pro Sesto | 16-02-2022 | 18:00 |
| Renate | Albinoleffe | 16-02-2022 | 18:00 |
| Giana Erminio | Sudtirol | 16-02-2022 | 18:00 |
| Fiorenzuola | Trento | 16-02-2022 | 18:00 |
| Juventus U23 | Piacenza | 16-02-2022 | 18:00 |
| Giana Erminio | Sudtirol | 16-02-2022 | 18:00 |
| Fiorenzuola | Trento | 16-02-2022 | 18:00 |
| Pergolettese | Legnago Salus | 16-02-2022 | 18:00 |
| Giana Erminio | Sudtirol | 16-02-2022 | 18:00 |
| Fiorenzuola | Trento | 16-02-2022 | 18:00 |
| Feralpisalo | PRO Vercelli | 16-02-2022 | 18:00 |
| Giana Erminio | Sudtirol | 16-02-2022 | 18:00 |
| Fiorenzuola | Trento | 16-02-2022 | 18:00 |
| Giana Erminio | Sudtirol | 16-02-2022 | 18:00 |
| Fiorenzuola | Trento | 16-02-2022 | 18:00 |
| Mantova | Seregno | 16-02-2022 | 18:00 |
| Padova | Lecco | 16-02-2022 | 18:00 |
| Giana Erminio | Sudtirol | 16-02-2022 | 18:00 |
| Fiorenzuola | Trento | 16-02-2022 | 18:00 |
| Triestina | Virtus Verona | 16-02-2022 | 18:00 |
| Giana Erminio | Sudtirol | 16-02-2022 | 18:00 |
| Fiorenzuola | Trento | 16-02-2022 | 18:00 |
| Monterosi | Messina | 16-02-2022 | 18:00 |
| Giana Erminio | Sudtirol | 16-02-2022 | 18:00 |
| Fiorenzuola | Trento | 16-02-2022 | 18:00 |
| Turris | Bari | 16-02-2022 | 18:00 |
| Foggia | Palermo | 16-02-2022 | 18:00 |
| Fidelis Andria | Potenza | 16-02-2022 | 18:00 |
| AZ Picerno | Latina | 16-02-2022 | 18:00 |
| Virtus Francavilla | Avellino | 16-02-2022 | 18:00 |
| Vibonese | Taranto | 16-02-2022 | 18:00 |
| Atletico Madrid | Levante | 16-02-2022 | 19:00 |
| Red Bull Salzburg | Bayern Munich | 16-02-2022 | 21:00 |
| Inter | Liverpool | 16-02-2022 | 21:00 |
| Red Bull Salzburg | Bayern Munich | 16-02-2022 | 21:00 |
| Modena | Montevarchi Calcio | 16-02-2022 | 21:00 |
| Carrarese | Imolese | 16-02-2022 | 21:00 |
| Pontedera | Gubbio | 16-02-2022 | 21:00 |
| Robur Siena | Fermana | 16-02-2022 | 21:00 |
| Vis Pesaro | Lucchese | 16-02-2022 | 21:00 |
| Grosseto | Viterbese | 16-02-2022 | 21:00 |
| Ancona | Cesena | 16-02-2022 | 21:00 |
| Olbia | Reggiana | 16-02-2022 | 21:00 |
| Teramo | Pistoiese | 16-02-2022 | 21:00 |
| Pescara | Virtus Entella | 16-02-2022 | 21:00 |
| Borussia Dortmund | Rangers | 17-02-2022 | 18:45 |
| Barcelona | Napoli | 17-02-2022 | 18:45 |
| Harrogate Town | Mansfield Town | 17-02-2022 | 20:45 |
| RB Leipzig | Real Sociedad | 17-02-2022 | 21:00 |
| Atalanta | Olympiakos Piraeus | 17-02-2022 | 21:00 |
| RB Leipzig | Real Sociedad | 17-02-2022 | 21:00 |
| FC Porto | Lazio | 17-02-2022 | 21:00 |
| Sevilla | Dinamo Zagreb | 17-02-2022 | 21:00 |
| Boulogne | Bastia-Borgo | 18-02-2022 | 01:00 |
| Royal Excel Mouscron | Excelsior Virton | 18-02-2022 | 01:00 |
| Deinze | Lommel United | 18-02-2022 | 01:00 |
| Waasland-beveren | RWDM | 18-02-2022 | 01:00 |
| Chambly Thelle FC | Villefranche | 18-02-2022 | 01:00 |
| Lierse Kempenzonen | KVC Westerlo | 18-02-2022 | 01:00 |
| RED Star FC 93 | Annecy | 18-02-2022 | 01:00 |
| Laval | Avranches | 18-02-2022 | 01:00 |
| Sedan | Le Mans | 18-02-2022 | 01:00 |
| Orleans | Stade Briochin | 18-02-2022 | 01:00 |
| Concarneau | Cholet | 18-02-2022 | 01:00 |
| Bourg-en-bresse 01 | Creteil | 18-02-2022 | 01:00 |
| FC Schalke 04 | SC Paderborn 07 | 18-02-2022 | 18:30 |
| Dynamo Dresden | FC Heidenheim | 18-02-2022 | 18:30 |
| Verl | FSV Zwickau | 18-02-2022 | 19:00 |
| Dordrecht | FC OSS | 18-02-2022 | 20:00 |
| Telstar | NAC Breda | 18-02-2022 | 20:00 |
| Den Bosch | Jong PSV | 18-02-2022 | 20:00 |
| FC Eindhoven | ADO Den Haag | 18-02-2022 | 20:00 |
| Helmond Sport | VVV Venlo | 18-02-2022 | 20:00 |
| MVV | Jong AZ | 18-02-2022 | 20:00 |
| Fortuna Sittard | Sparta Rotterdam | 18-02-2022 | 20:00 |
| Roda | De Graafschap | 18-02-2022 | 20:00 |
| Emmen | FC Volendam | 18-02-2022 | 20:00 |
| Roda | De Graafschap | 18-02-2022 | 20:00 |
| FSV Mainz 05 | Bayer Leverkusen | 18-02-2022 | 20:30 |
| Southend | Grimsby | 18-02-2022 | 20:45 |
| Rotherham | Wigan | 18-02-2022 | 20:45 |
| Larne | Glentoran | 18-02-2022 | 20:45 |
| Dungannon Swifts | Cliftonville FC | 18-02-2022 | 20:45 |
| Oostende | Standard Liege | 19-02-2022 | 01:00 |
| Cercle Brugge | Beerschot Wilrijk | 19-02-2022 | 01:00 |
| Penybont | Taffs Well | 19-02-2022 | 01:00 |
| Kortrijk | Zulte Waregem | 19-02-2022 | 01:00 |
| Quevilly | Valenciennes | 19-02-2022 | 01:00 |
| The New Saints | Guilsfield | 19-02-2022 | 01:00 |
| Gent | Seraing United | 19-02-2022 | 01:00 |
| GAP Connah S Quay FC | Colwyn Bay | 19-02-2022 | 01:00 |
| Bala Town | Aberystwyth Town | 19-02-2022 | 01:00 |
| Anderlecht | Genk | 19-02-2022 | 01:00 |
| Antwerp | KV Mechelen | 19-02-2022 | 01:00 |
| Charleroi | Union St. Gilloise | 19-02-2022 | 01:00 |
| St. Truiden | OH Leuven | 19-02-2022 | 01:00 |
| Guingamp | Paris FC | 19-02-2022 | 01:00 |
| AS Eupen | Club Brugge KV | 19-02-2022 | 01:00 |
| Nancy | Dunkerque | 19-02-2022 | 01:00 |
| Niort | Auxerre | 19-02-2022 | 01:00 |
| Sochaux | Ajaccio | 19-02-2022 | 01:00 |
| Rodez | Amiens | 19-02-2022 | 01:00 |
| Toulouse | LE Havre | 19-02-2022 | 01:00 |
| PAU | Caen | 19-02-2022 | 01:00 |
| Nimes | Grenoble | 19-02-2022 | 01:00 |
| Bastia | Dijon | 19-02-2022 | 01:00 |
| West Ham | Newcastle | 19-02-2022 | 13:30 |
| SV Sandhausen | Hamburger SV | 19-02-2022 | 13:30 |
| Holstein Kiel | Karlsruher SC | 19-02-2022 | 13:30 |
| MSV Duisburg | Türkgücü-Ataspor | 19-02-2022 | 14:00 |
| FC Saarbrucken | FC Viktoria Koln | 19-02-2022 | 14:00 |
| VfL Osnabruck | Eintracht Braunschweig | 19-02-2022 | 14:00 |
| SV Wehen | Viktoria Berlin | 19-02-2022 | 14:00 |
| Freiburg II | SV Meppen | 19-02-2022 | 14:00 |
| FC Magdeburg | Borussia Dortmund II | 19-02-2022 | 14:00 |
| Noordwijk | Volendam II | 19-02-2022 | 14:30 |
| GVVV Veenendaal | Kozakken Boys | 19-02-2022 | 14:30 |
| Northampton | Colchester | 19-02-2022 | 15:00 |
| ASWH | Rijnsburgse Boys | 19-02-2022 | 15:00 |
| Ijsselmeervogels | Koninklijke HFC | 19-02-2022 | 15:00 |
| como | Nuova Cosenza | 19-02-2022 | 15:00 |
| Monza | Pisa | 19-02-2022 | 15:00 |
| Brescia | Frosinone | 19-02-2022 | 15:00 |
| Parma | Ternana | 19-02-2022 | 15:00 |
| Vicenza Virtus | Spal | 19-02-2022 | 15:00 |
| Cittadella | Benevento | 19-02-2022 | 15:00 |
| Perugia | Cremonese | 19-02-2022 | 15:00 |
| Ascoli | Alessandria | 19-02-2022 | 15:00 |
| Lecce | Crotone | 19-02-2022 | 15:00 |
| Reggina | Pordenone | 19-02-2022 | 15:00 |
| Katwijk | Spakenburg | 19-02-2022 | 15:30 |
| TEC | Quick Boys | 19-02-2022 | 15:30 |
| HHC | Sparta Rotterdam II | 19-02-2022 | 15:30 |
| Arminia Bielefeld | Union Berlin | 19-02-2022 | 15:30 |
| VfB Stuttgart | VfL BOCHUM | 19-02-2022 | 15:30 |
| VfL Wolfsburg | 1899 Hoffenheim | 19-02-2022 | 15:30 |
| FC Augsburg | SC Freiburg | 19-02-2022 | 15:30 |
| Arsenal | Brentford | 19-02-2022 | 16:00 |
| Fulham | Huddersfield | 19-02-2022 | 16:00 |
| QPR | Hull City | 19-02-2022 | 16:00 |
| Charlton | Oxford United | 19-02-2022 | 16:00 |
| Crystal Palace | Chelsea | 19-02-2022 | 16:00 |
| Wealdstone | Wrexham | 19-02-2022 | 16:00 |
| Maidenhead | Boreham Wood | 19-02-2022 | 16:00 |
| Stevenage | Bristol Rovers | 19-02-2022 | 16:00 |
| Luton | West Brom | 19-02-2022 | 16:00 |
| Wycombe | Cheltenham | 19-02-2022 | 16:00 |
| Gillingham | Plymouth | 19-02-2022 | 16:00 |
| Brighton | Burnley | 19-02-2022 | 16:00 |
| Cambridge United | Accrington ST | 19-02-2022 | 16:00 |
| Ipswich | Burton Albion | 19-02-2022 | 16:00 |
| Southampton | Everton | 19-02-2022 | 16:00 |
| King's Lynn Town | Bromley | 19-02-2022 | 16:00 |
| Bournemouth | Nottingham Forest | 19-02-2022 | 16:00 |
| Forest Green | Walsall | 19-02-2022 | 16:00 |
| Coventry | Barnsley | 19-02-2022 | 16:00 |
| Aston Villa | Watford | 19-02-2022 | 16:00 |
| Bristol City | Middlesbrough | 19-02-2022 | 16:00 |
| Notts County | Eastleigh | 19-02-2022 | 16:00 |
| Derby | Peterborough | 19-02-2022 | 16:00 |
| Yeovil Town | Dagenham & Redbridge | 19-02-2022 | 16:00 |
| Newport County | Mansfield Town | 19-02-2022 | 16:00 |
| Cardiff | Blackpool | 19-02-2022 | 16:00 |
| Chesterfield | Solihull Moors | 19-02-2022 | 16:00 |
| Stoke City | Birmingham | 19-02-2022 | 16:00 |
| Shrewsbury | Morecambe | 19-02-2022 | 16:00 |
| Sheffield Utd | Swansea | 19-02-2022 | 16:00 |
| Doncaster | Sheffield Wednesday | 19-02-2022 | 16:00 |
| Scunthorpe | Rochdale | 19-02-2022 | 16:00 |
| Crewe | Portsmouth | 19-02-2022 | 16:00 |
| Stockport County | Woking | 19-02-2022 | 16:00 |
| Exeter City | Barrow | 19-02-2022 | 16:00 |
| Altrincham | Weymouth | 19-02-2022 | 16:00 |
| Torquay | Barnet | 19-02-2022 | 16:00 |
| Oldham | Bradford | 19-02-2022 | 16:00 |
| Salford City | Crawley Town | 19-02-2022 | 16:00 |
| FC Halifax Town | Dover | 19-02-2022 | 16:00 |
| Bolton | AFC Wimbledon | 19-02-2022 | 16:00 |
| Tranmere | Port Vale | 19-02-2022 | 16:00 |
| Liverpool | Norwich | 19-02-2022 | 16:00 |
| Cowdenbeath | Elgin City | 19-02-2022 | 16:00 |
| Harrogate Town | Leyton Orient | 19-02-2022 | 16:00 |
| Blackburn | Millwall | 19-02-2022 | 16:00 |
| Preston | Reading | 19-02-2022 | 16:00 |
| Fleetwood Town | Lincoln | 19-02-2022 | 16:00 |
| Hartlepool | Sutton Utd | 19-02-2022 | 16:00 |
| Sunderland | Milton Keynes Dons | 19-02-2022 | 16:00 |
| Carlisle | Swindon Town | 19-02-2022 | 16:00 |
| Annan Athletic | Edinburgh City | 19-02-2022 | 16:00 |
| Queen of the South | Arbroath | 19-02-2022 | 16:00 |
| Stranraer | Stenhousemuir | 19-02-2022 | 16:00 |
| Warrenpoint Town | Coleraine FC | 19-02-2022 | 16:00 |
| Ards | Institute | 19-02-2022 | 16:00 |
| Ballymena United | Glenavon FC | 19-02-2022 | 16:00 |
| Newry City AFC | Knockbreda | 19-02-2022 | 16:00 |
| Dundela | Ballinamallard United | 19-02-2022 | 16:00 |
| Queen's University | Dergview | 19-02-2022 | 16:00 |
| Linfield | Portadown | 19-02-2022 | 16:00 |
| Crusaders FC | Carrick Rangers | 19-02-2022 | 16:00 |
| Annagh United | H&W Welders | 19-02-2022 | 16:00 |
| Hibernian | Ross County | 19-02-2022 | 16:00 |
| Livingston | ST Mirren | 19-02-2022 | 16:00 |
| Motherwell | Aberdeen | 19-02-2022 | 16:00 |
| Kilmarnock | Raith Rovers | 19-02-2022 | 16:00 |
| Loughgall | Ballyclare Comrades | 19-02-2022 | 16:00 |
| Hamilton Academical | Morton | 19-02-2022 | 16:00 |
| Dunfermline | Partick | 19-02-2022 | 16:00 |
| Ballymena United | Glenavon FC | 19-02-2022 | 16:00 |
| Newry City AFC | Knockbreda | 19-02-2022 | 16:00 |
| Cowdenbeath | Elgin City | 19-02-2022 | 16:00 |
| East Fife | Queen's Park | 19-02-2022 | 16:00 |
| Stirling Albion | Albion Rovers | 19-02-2022 | 16:00 |
| Dumbarton | Alloa Athletic | 19-02-2022 | 16:00 |
| ST Johnstone | Heart OF Midlothian | 19-02-2022 | 16:00 |
| Ballymena United | Glenavon FC | 19-02-2022 | 16:00 |
| Newry City AFC | Knockbreda | 19-02-2022 | 16:00 |
| Montrose | Clyde | 19-02-2022 | 16:00 |
| Ballymena United | Glenavon FC | 19-02-2022 | 16:00 |
| Newry City AFC | Knockbreda | 19-02-2022 | 16:00 |
| Forfar Athletic | Kelty Hearts | 19-02-2022 | 16:00 |
| Cove Rangers | Falkirk | 19-02-2022 | 16:00 |
| Ballymena United | Glenavon FC | 19-02-2022 | 16:00 |
| Newry City AFC | Knockbreda | 19-02-2022 | 16:00 |
| Peterhead | Airdrie United | 19-02-2022 | 16:00 |
| Inverness CT | Ayr Utd | 19-02-2022 | 16:00 |
| Forfar Athletic | Kelty Hearts | 19-02-2022 | 16:00 |
| NEC Nijmegen | Waalwijk | 19-02-2022 | 16:30 |
| Bari | Città di Campobasso | 19-02-2022 | 17:30 |
| Manchester City | Tottenham | 19-02-2022 | 18:30 |
| FC Koln | Eintracht Frankfurt | 19-02-2022 | 18:30 |
| Willem II | Ajax | 19-02-2022 | 18:45 |
| AZ Alkmaar | Heracles | 19-02-2022 | 21:00 |
| Lens | Lyon | 20-02-2022 | 01:00 |
| Lille | Metz | 20-02-2022 | 01:00 |
| Lille | Metz | 20-02-2022 | 01:00 |
| Reims | Stade Brestois 29 | 20-02-2022 | 01:00 |
| Rennes | Estac Troyes | 20-02-2022 | 01:00 |
| Lorient | Montpellier | 20-02-2022 | 01:00 |
| Nantes | Paris Saint Germain | 20-02-2022 | 01:00 |
| Werder Bremen | FC Ingolstadt 04 | 20-02-2022 | 01:00 |
| Bordeaux | Monaco | 20-02-2022 | 01:00 |
| Saint Etienne | Strasbourg | 20-02-2022 | 01:00 |
| FC Nurnberg | Jahn Regensburg | 20-02-2022 | 01:00 |
| Juventus | Torino | 20-02-2022 | 01:00 |
| Real Sociedad II | Malaga | 20-02-2022 | 01:00 |
| Athletic Club | Real Sociedad | 20-02-2022 | 01:00 |
| Amorebieta | Leganes | 20-02-2022 | 01:00 |
| Inter | Sassuolo | 20-02-2022 | 01:00 |
| Osasuna | Atletico Madrid | 20-02-2022 | 01:00 |
| Sporting Gijon | Ponferradina | 20-02-2022 | 01:00 |
| Marseille | Clermont Foot | 20-02-2022 | 01:00 |
| Nice | Angers | 20-02-2022 | 01:00 |
| Sampdoria | Empoli | 20-02-2022 | 01:00 |
| Huesca | Lugo | 20-02-2022 | 01:00 |
| Burgos | Oviedo | 20-02-2022 | 01:00 |
| Girona | Eibar | 20-02-2022 | 01:00 |
| Zaragoza | Las Palmas | 20-02-2022 | 01:00 |
| Venezia | Genoa | 20-02-2022 | 01:00 |
| Espanyol | Sevilla | 20-02-2022 | 01:00 |
| Udinese | Lazio | 20-02-2022 | 01:00 |
| Bologna | Spezia | 20-02-2022 | 01:00 |
| Fiorentina | Atalanta | 20-02-2022 | 01:00 |
| Celta Vigo | Levante | 20-02-2022 | 01:00 |
| Real Madrid | Alaves | 20-02-2022 | 01:00 |
| Fuenlabrada | Alcorcon | 20-02-2022 | 01:00 |
| Guimaraes | Arouca | 20-02-2022 | 01:00 |
| GIL Vicente | Belenenses | 20-02-2022 | 01:00 |
| Moreirense | FC Porto | 20-02-2022 | 01:00 |
| Pacos Ferreira | Vizela | 20-02-2022 | 01:00 |
| Trofense | Mafra | 20-02-2022 | 01:00 |
| Penafiel | SC Covilha | 20-02-2022 | 01:00 |
| Santa Clara | Portimonense | 20-02-2022 | 01:00 |
| Boavista | Benfica | 20-02-2022 | 01:00 |
| FC Porto B | Chaves | 20-02-2022 | 01:00 |
| Valencia | Barcelona | 20-02-2022 | 01:00 |
| Feirense | Rio Ave | 20-02-2022 | 01:00 |
| Academico Viseu | Leixoes | 20-02-2022 | 01:00 |
| Tondela | SC Braga | 20-02-2022 | 01:00 |
| AS Roma | Verona | 20-02-2022 | 01:00 |
| Elche | Rayo Vallecano | 20-02-2022 | 01:00 |
| Vilafranquense | Academica | 20-02-2022 | 01:00 |
| Cagliari | Napoli | 20-02-2022 | 01:00 |
| FC Cartagena | Valladolid | 20-02-2022 | 01:00 |
| Sporting CP | Estoril | 20-02-2022 | 01:00 |
| Casa Pia | Nacional | 20-02-2022 | 01:00 |
| Benfica B | Farense | 20-02-2022 | 01:00 |
| Estrela | Varzim | 20-02-2022 | 01:00 |
| Granada CF | Villarreal | 20-02-2022 | 01:00 |
| Real Betis | Mallorca | 20-02-2022 | 01:00 |
| Almeria | Mirandes | 20-02-2022 | 01:00 |
| Penafiel | SC Covilha | 20-02-2022 | 01:00 |
| Salernitana | AC Milan | 20-02-2022 | 01:00 |
| Cadiz | Getafe | 20-02-2022 | 01:00 |
| Besiktas | Altay | 20-02-2022 | 01:00 |
| Maritimo | Famalicao | 20-02-2022 | 01:00 |
| Fenerbahce | Hatayspor | 20-02-2022 | 01:00 |
| Santa Clara | Portimonense | 20-02-2022 | 01:00 |
| Tuzlaspor | Kocaelispor | 20-02-2022 | 01:00 |
| Goztepe | Galatasaray | 20-02-2022 | 01:00 |
| Manisa BBSK | Ümraniyespor | 20-02-2022 | 01:00 |
| Boluspor | Genclerbirligi | 20-02-2022 | 01:00 |
| Ankaragucu | Bursaspor | 20-02-2022 | 01:00 |
| Tenerife | Ibiza | 20-02-2022 | 01:00 |
| Konyaspor | Kasimpasa | 20-02-2022 | 01:00 |
| Samsunspor | Denizlispor | 20-02-2022 | 01:00 |
| Alanyaspor | Trabzonspor | 20-02-2022 | 01:00 |
| Kayserispor | Giresunspor | 20-02-2022 | 01:00 |
| Adanaspor | Erzurum BB | 20-02-2022 | 01:00 |
| Rizespor | Istanbul Basaksehir | 20-02-2022 | 01:00 |
| Yeni Malatyaspor | Antalyaspor | 20-02-2022 | 01:00 |
| PEC Zwolle | Groningen | 20-02-2022 | 12:15 |
| Dundee Utd | Rangers | 20-02-2022 | 13:00 |
| Havelse | FC Wurzburger Kickers | 20-02-2022 | 13:00 |
| Fortuna Dusseldorf | Erzgebirge AUE | 20-02-2022 | 13:30 |
| SV Darmstadt 98 | Hansa Rostock | 20-02-2022 | 13:30 |
| FC St. Pauli | Hannover 96 | 20-02-2022 | 13:30 |
| Waldhof Mannheim | FC Kaiserslautern | 20-02-2022 | 14:00 |
| Feyenoord | Cambuur | 20-02-2022 | 14:30 |
| AFC Amsterdam | De Treffers | 20-02-2022 | 14:30 |
| Twente | GO Ahead Eagles | 20-02-2022 | 14:30 |
| Albinoleffe | Pergolettese | 20-02-2022 | 14:30 |
| Fiorenzuola | Triestina | 20-02-2022 | 14:30 |
| Albinoleffe | Pergolettese | 20-02-2022 | 14:30 |
| Fiorenzuola | Triestina | 20-02-2022 | 14:30 |
| PRO Vercelli | Renate | 20-02-2022 | 14:30 |
| Lecco | Mantova | 20-02-2022 | 14:30 |
| Seregno | Juventus U23 | 20-02-2022 | 14:30 |
| Pro Sesto | Piacenza | 20-02-2022 | 14:30 |
| Albinoleffe | Pergolettese | 20-02-2022 | 14:30 |
| Fiorenzuola | Triestina | 20-02-2022 | 14:30 |
| Albinoleffe | Pergolettese | 20-02-2022 | 14:30 |
| Fiorenzuola | Triestina | 20-02-2022 | 14:30 |
| Sudtirol | Pro Patria | 20-02-2022 | 14:30 |
| Albinoleffe | Pergolettese | 20-02-2022 | 14:30 |
| Fiorenzuola | Triestina | 20-02-2022 | 14:30 |
| Albinoleffe | Pergolettese | 20-02-2022 | 14:30 |
| Fiorenzuola | Triestina | 20-02-2022 | 14:30 |
| Albinoleffe | Pergolettese | 20-02-2022 | 14:30 |
| Fiorenzuola | Triestina | 20-02-2022 | 14:30 |
| Virtus Verona | Giana Erminio | 20-02-2022 | 14:30 |
| Legnago Salus | Feralpisalo | 20-02-2022 | 14:30 |
| Albinoleffe | Pergolettese | 20-02-2022 | 14:30 |
| Fiorenzuola | Triestina | 20-02-2022 | 14:30 |
| Albinoleffe | Pergolettese | 20-02-2022 | 14:30 |
| Fiorenzuola | Triestina | 20-02-2022 | 14:30 |
| Albinoleffe | Pergolettese | 20-02-2022 | 14:30 |
| Fiorenzuola | Triestina | 20-02-2022 | 14:30 |
| Leeds | Manchester United | 20-02-2022 | 15:00 |
| Bayern Munich | SpVgg Greuther Furth | 20-02-2022 | 15:30 |
| Celtic | Dundee | 20-02-2022 | 16:00 |
| Celtic | Dundee | 20-02-2022 | 16:00 |
| Utrecht | Vitesse | 20-02-2022 | 16:45 |
| PSV Eindhoven | Heerenveen | 20-02-2022 | 16:45 |
| Wolves | Leicester | 20-02-2022 | 17:30 |
| Borussia Dortmund | Borussia Monchengladbach | 20-02-2022 | 17:30 |
| Reggiana | Grosseto | 20-02-2022 | 17:30 |
| Lucchese | Pontedera | 20-02-2022 | 17:30 |
| Pistoiese | Carrarese | 20-02-2022 | 17:30 |
| Imolese | Olbia | 20-02-2022 | 17:30 |
| Cesena | Vis Pesaro | 20-02-2022 | 17:30 |
| Montevarchi Calcio | Ancona | 20-02-2022 | 17:30 |
| Gubbio | Teramo | 20-02-2022 | 17:30 |
| Viterbese | Modena | 20-02-2022 | 17:30 |
| Fermana | Pescara | 20-02-2022 | 17:30 |
| Latina | Vibonese | 20-02-2022 | 17:30 |
| Avellino | Fidelis Andria | 20-02-2022 | 17:30 |
| Paganese | Monterosi | 20-02-2022 | 17:30 |
| AZ Picerno | Juve Stabia | 20-02-2022 | 17:30 |
| Wolves | Leicester | 20-02-2022 | 17:30 |
| SS Monopoli | Foggia | 20-02-2022 | 17:30 |
| Taranto | Catanzaro | 20-02-2022 | 17:30 |
| Palermo | Turris | 20-02-2022 | 17:30 |
| Messina | Potenza | 20-02-2022 | 17:30 |
| Catania | Virtus Francavilla | 20-02-2022 | 17:30 |
| Hertha Berlin | RB Leipzig | 20-02-2022 | 19:30 |
| TSV 1860 Munich | Hallescher FC | 21-02-2022 | 19:00 |
| Jong Ajax | Almere City FC | 21-02-2022 | 20:00 |
| Virtus Entella | Robur Siena | 21-02-2022 | 21:00 |
| Alessandria | Perugia | 22-02-2022 | 15:00 |
| Brescia | Ascoli | 22-02-2022 | 15:00 |
| Cremonese | Vicenza Virtus | 22-02-2022 | 15:00 |
| Spal | Ternana | 22-02-2022 | 15:00 |
| Pordenone | Monza | 22-02-2022 | 15:00 |
| Pisa | Parma | 22-02-2022 | 15:00 |
| Frosinone | Reggina | 22-02-2022 | 15:00 |
| Benevento | como | 22-02-2022 | 15:00 |
| Lecce | Cittadella | 22-02-2022 | 15:00 |
| Crotone | Nuova Cosenza | 22-02-2022 | 15:00 |
| Leyton Orient | Bristol Rovers | 22-02-2022 | 20:45 |
| Charlton | Milton Keynes Dons | 22-02-2022 | 20:45 |
| Barnet | King's Lynn Town | 22-02-2022 | 20:45 |
| Dagenham & Redbridge | Woking | 22-02-2022 | 20:45 |
| Maidenhead | Yeovil Town | 22-02-2022 | 20:45 |
| Wycombe | Wigan | 22-02-2022 | 20:45 |
| Gillingham | AFC Wimbledon | 22-02-2022 | 20:45 |
| Aldershot Town | Dover | 22-02-2022 | 20:45 |
| Cambridge United | Plymouth | 22-02-2022 | 20:45 |
| Colchester | Hartlepool | 22-02-2022 | 20:45 |
| Ipswich | Cheltenham | 22-02-2022 | 20:45 |
| Eastleigh | Southend | 22-02-2022 | 20:45 |
| Swindon Town | Walsall | 22-02-2022 | 20:45 |
| Solihull Moors | Wealdstone | 22-02-2022 | 20:45 |
| Bristol City | Coventry | 22-02-2022 | 20:45 |
| Notts County | FC Halifax Town | 22-02-2022 | 20:45 |
| Weymouth | Bromley | 22-02-2022 | 20:45 |
| Chesterfield | Wrexham | 22-02-2022 | 20:45 |
| Shrewsbury | Portsmouth | 22-02-2022 | 20:45 |
| Rotherham | Morecambe | 22-02-2022 | 20:45 |
| Doncaster | Accrington ST | 22-02-2022 | 20:45 |
| Crewe | Oxford United | 22-02-2022 | 20:45 |
| Hull City | Barnsley | 22-02-2022 | 20:45 |
| Swansea | Bournemouth | 22-02-2022 | 20:45 |
| Torquay | Boreham Wood | 22-02-2022 | 20:45 |
| Rochdale | Port Vale | 22-02-2022 | 20:45 |
| Preston | Nottingham Forest | 22-02-2022 | 20:45 |
| Fleetwood Town | Sheffield Wednesday | 22-02-2022 | 20:45 |
| Middlesbrough | West Brom | 22-02-2022 | 20:45 |
| Sunderland | Burton Albion | 22-02-2022 | 20:45 |
| Middlesbrough | West Brom | 22-02-2022 | 20:45 |
| Chelsea | Lille | 22-02-2022 | 21:00 |
| Reading | Birmingham | 22-02-2022 | 21:00 |
| Bolton | Lincoln | 22-02-2022 | 21:00 |
| Villarreal | Juventus | 22-02-2022 | 21:00 |
| Latina | Avellino | 22-02-2022 | 21:00 |
| Turris | Foggia | 22-02-2022 | 21:00 |
| Juve Stabia | Vibonese | 22-02-2022 | 21:00 |
| Potenza | Catanzaro | 22-02-2022 | 21:00 |
| Bari | AZ Picerno | 22-02-2022 | 21:00 |
| Palermo | Taranto | 22-02-2022 | 21:00 |
| Virtus Francavilla | Fidelis Andria | 22-02-2022 | 21:00 |
| Messina | SS Monopoli | 22-02-2022 | 21:00 |
| Catania | Paganese | 22-02-2022 | 21:00 |
| Albinoleffe | Fiorenzuola | 23-02-2022 | 18:00 |
| Albinoleffe | Fiorenzuola | 23-02-2022 | 18:00 |
| Lecco | Giana Erminio | 23-02-2022 | 18:00 |
| Seregno | PRO Vercelli | 23-02-2022 | 18:00 |
| Pro Sesto | Pergolettese | 23-02-2022 | 18:00 |
| Albinoleffe | Fiorenzuola | 23-02-2022 | 18:00 |
| Juventus U23 | Pro Patria | 23-02-2022 | 18:00 |
| Albinoleffe | Fiorenzuola | 23-02-2022 | 18:00 |
| Albinoleffe | Fiorenzuola | 23-02-2022 | 18:00 |
| Piacenza | Triestina | 23-02-2022 | 18:00 |
| Albinoleffe | Fiorenzuola | 23-02-2022 | 18:00 |
| Albinoleffe | Fiorenzuola | 23-02-2022 | 18:00 |
| Virtus Verona | Renate | 23-02-2022 | 18:00 |
| Mantova | Feralpisalo | 23-02-2022 | 18:00 |
| Padova | Legnago Salus | 23-02-2022 | 18:00 |
| Albinoleffe | Fiorenzuola | 23-02-2022 | 18:00 |
| Albinoleffe | Fiorenzuola | 23-02-2022 | 18:00 |
| Albinoleffe | Fiorenzuola | 23-02-2022 | 18:00 |
| Fulham | Peterborough | 23-02-2022 | 20:45 |
| QPR | Blackpool | 23-02-2022 | 20:45 |
| Derby | Millwall | 23-02-2022 | 20:45 |
| Stoke City | Luton | 23-02-2022 | 20:45 |
| Sheffield Utd | Blackburn | 23-02-2022 | 20:45 |
| Huddersfield | Cardiff | 23-02-2022 | 20:45 |
| Pistoiese | Pontedera | 23-02-2022 | 21:00 |
| Imolese | Cesena | 23-02-2022 | 21:00 |
| Montevarchi Calcio | Fermana | 23-02-2022 | 21:00 |
| Atletico Madrid | Manchester United | 23-02-2022 | 21:00 |
| Vis Pesaro | Pescara | 23-02-2022 | 21:00 |
| Gubbio | Reggiana | 23-02-2022 | 21:00 |
| Ancona | Grosseto | 23-02-2022 | 21:00 |
| Viterbese | Olbia | 23-02-2022 | 21:00 |
| Teramo | Modena | 23-02-2022 | 21:00 |
| Real Sociedad | RB Leipzig | 24-02-2022 | 18:45 |
| Dinamo Zagreb | Sevilla | 24-02-2022 | 18:45 |
| Lazio | FC Porto | 24-02-2022 | 18:45 |
| Olympiakos Piraeus | Atalanta | 24-02-2022 | 18:45 |
| Rangers | Borussia Dortmund | 24-02-2022 | 21:00 |
| Carrarese | Robur Siena | 24-02-2022 | 21:00 |
| Lucchese | Virtus Entella | 24-02-2022 | 21:00 |
| SC Braga | Sheriff Tiraspol | 24-02-2022 | 21:00 |
| Napoli | Barcelona | 24-02-2022 | 21:00 |
| Real Betis | Zenit Saint Petersburg | 24-02-2022 | 21:00 |
| RWDM | Lierse Kempenzonen | 25-02-2022 | 01:00 |
| Avranches | Concarneau | 25-02-2022 | 01:00 |
| KVC Westerlo | Waasland-beveren | 25-02-2022 | 01:00 |
| Creteil | Sedan | 25-02-2022 | 01:00 |
| Lommel United | Royal Excel Mouscron | 25-02-2022 | 01:00 |
| Stade Briochin | Sète | 25-02-2022 | 01:00 |
| Le Mans | Laval | 25-02-2022 | 01:00 |
| Excelsior Virton | Deinze | 25-02-2022 | 01:00 |
| Cholet | Boulogne | 25-02-2022 | 01:00 |
| FC Viktoria Koln | Havelse | 25-02-2022 | 01:00 |
| SV Meppen | VfL Osnabruck | 25-02-2022 | 01:00 |
| Borussia Dortmund II | SV Wehen | 25-02-2022 | 01:00 |
| Chateauroux | Bourg-en-bresse 01 | 25-02-2022 | 01:00 |
| FC Kaiserslautern | Verl | 25-02-2022 | 01:00 |
| Annecy | Orleans | 25-02-2022 | 01:00 |
| Villefranche | RED Star FC 93 | 25-02-2022 | 01:00 |
| FC Wurzburger Kickers | FC Magdeburg | 25-02-2022 | 01:00 |
| Eintracht Braunschweig | MSV Duisburg | 25-02-2022 | 01:00 |
| Annecy | Orleans | 25-02-2022 | 01:00 |
| Hallescher FC | Waldhof Mannheim | 25-02-2022 | 01:00 |
| FSV Zwickau | TSV 1860 Munich | 25-02-2022 | 01:00 |
| Annecy | Orleans | 25-02-2022 | 01:00 |
| Viktoria Berlin | Freiburg II | 25-02-2022 | 01:00 |
| Bastia-Borgo | Chambly Thelle FC | 25-02-2022 | 01:00 |
| SC Paderborn 07 | Erzgebirge AUE | 25-02-2022 | 18:30 |
| Hannover 96 | Holstein Kiel | 25-02-2022 | 18:30 |
| Excelsior | Roda | 25-02-2022 | 20:00 |
| ADO Den Haag | Telstar | 25-02-2022 | 20:00 |
| Dordrecht | MVV | 25-02-2022 | 20:00 |
| NAC Breda | Jong PSV | 25-02-2022 | 20:00 |
| Waalwijk | Twente | 25-02-2022 | 20:00 |
| Almere City FC | VVV Venlo | 25-02-2022 | 20:00 |
| FC OSS | Jong Utrecht | 25-02-2022 | 20:00 |
| De Graafschap | Den Bosch | 25-02-2022 | 20:00 |
| Emmen | Jong Ajax | 25-02-2022 | 20:00 |
| Taffs Well | Risca United | 25-02-2022 | 20:30 |
| Briton Ferry | Afan Lido | 25-02-2022 | 20:30 |
| Gresford Athletic | Bangor City | 25-02-2022 | 20:30 |
| Buckley Town | Llangefni Town | 25-02-2022 | 20:30 |
| llanelli AFC | Port Talbot Town | 25-02-2022 | 20:30 |
| Ruthin Town | Holyhead Hotspur | 25-02-2022 | 20:30 |
| 1899 Hoffenheim | VfB Stuttgart | 25-02-2022 | 20:30 |
| Carrick Rangers | Linfield | 25-02-2022 | 20:45 |
| Edinburgh City | Cowdenbeath | 25-02-2022 | 20:45 |
| Southampton | Norwich | 25-02-2022 | 21:00 |
| Dunkerque | Dijon | 26-02-2022 | 01:00 |
| Oostende | St. Truiden | 26-02-2022 | 01:00 |
| LE Havre | Nancy | 26-02-2022 | 01:00 |
| Club Brugge KV | Antwerp | 26-02-2022 | 01:00 |
| Amiens | Nimes | 26-02-2022 | 01:00 |
| Zulte Waregem | Seraing United | 26-02-2022 | 01:00 |
| Caen | Bastia | 26-02-2022 | 01:00 |
| Valenciennes | PAU | 26-02-2022 | 01:00 |
| Beerschot Wilrijk | Charleroi | 26-02-2022 | 01:00 |
| Union St. Gilloise | AS Eupen | 26-02-2022 | 01:00 |
| KV Mechelen | Cercle Brugge | 26-02-2022 | 01:00 |
| OH Leuven | Anderlecht | 26-02-2022 | 01:00 |
| Paris FC | Sochaux | 26-02-2022 | 01:00 |
| Guingamp | Niort | 26-02-2022 | 01:00 |
| Genk | Kortrijk | 26-02-2022 | 01:00 |
| Standard Liege | Gent | 26-02-2022 | 01:00 |
| Auxerre | Quevilly | 26-02-2022 | 01:00 |
| Grenoble | Toulouse | 26-02-2022 | 01:00 |
| Ajaccio | Rodez | 26-02-2022 | 01:00 |
| Leeds | Tottenham | 26-02-2022 | 13:30 |
| Karlsruher SC | FC Schalke 04 | 26-02-2022 | 13:30 |
| Hansa Rostock | FC Nurnberg | 26-02-2022 | 13:30 |
| FC Ingolstadt 04 | FC St. Pauli | 26-02-2022 | 13:30 |
| Undy Athletic | Pontypridd Town | 26-02-2022 | 15:00 |
| Undy Athletic | Pontypridd Town | 26-02-2022 | 15:00 |
| Cwmbran Celtic | Ammanford AFC | 26-02-2022 | 15:00 |
| Llantwit Major | Trefelin | 26-02-2022 | 15:00 |
| Cwmbran Celtic | Ammanford AFC | 26-02-2022 | 15:00 |
| como | Brescia | 26-02-2022 | 15:00 |
| Monza | Lecce | 26-02-2022 | 15:00 |
| Parma | Spal | 26-02-2022 | 15:00 |
| Vicenza Virtus | Pordenone | 26-02-2022 | 15:00 |
| Cittadella | Frosinone | 26-02-2022 | 15:00 |
| Perugia | Benevento | 26-02-2022 | 15:00 |
| Ternana | Cremonese | 26-02-2022 | 15:00 |
| Ascoli | Crotone | 26-02-2022 | 15:00 |
| Nuova Cosenza | Alessandria | 26-02-2022 | 15:00 |
| Reggina | Pisa | 26-02-2022 | 15:00 |
| Cambrian & Clydach | Goytre United | 26-02-2022 | 15:30 |
| Swansea University | Carmarthen Town | 26-02-2022 | 15:30 |
| Airbus UK | Llanidloes Town | 26-02-2022 | 15:30 |
| Holywell | Llanrhaeadr | 26-02-2022 | 15:30 |
| Prestatyn Town | Colwyn Bay | 26-02-2022 | 15:30 |
| Conwy Borough | Guilsfield | 26-02-2022 | 15:30 |
| Llandudno | Penrhyncoch | 26-02-2022 | 15:30 |
| Borussia Monchengladbach | VfL Wolfsburg | 26-02-2022 | 15:30 |
| Bayer Leverkusen | Arminia Bielefeld | 26-02-2022 | 15:30 |
| SC Freiburg | Hertha Berlin | 26-02-2022 | 15:30 |
| SpVgg Greuther Furth | FC Koln | 26-02-2022 | 15:30 |
| Union Berlin | FSV Mainz 05 | 26-02-2022 | 15:30 |
| Arsenal | Liverpool | 26-02-2022 | 16:00 |
| Millwall | Sheffield Utd | 26-02-2022 | 16:00 |
| West Ham | Wolves | 26-02-2022 | 16:00 |
| Leyton Orient | Carlisle | 26-02-2022 | 16:00 |
| Brentford | Newcastle | 26-02-2022 | 16:00 |
| Crystal Palace | Burnley | 26-02-2022 | 16:00 |
| AFC Wimbledon | Doncaster | 26-02-2022 | 16:00 |
| Sutton Utd | Scunthorpe | 26-02-2022 | 16:00 |
| Boreham Wood | Eastleigh | 26-02-2022 | 16:00 |
| Wealdstone | Torquay | 26-02-2022 | 16:00 |
| Woking | Notts County | 26-02-2022 | 16:00 |
| Crawley Town | Forest Green | 26-02-2022 | 16:00 |
| Luton | Derby | 26-02-2022 | 16:00 |
| Southend | Solihull Moors | 26-02-2022 | 16:00 |
| Milton Keynes Dons | Bolton | 26-02-2022 | 16:00 |
| Brighton | Aston Villa | 26-02-2022 | 16:00 |
| Oxford United | Cambridge United | 26-02-2022 | 16:00 |
| Colchester | Oldham | 26-02-2022 | 16:00 |
| Portsmouth | Fleetwood Town | 26-02-2022 | 16:00 |
| Dover | Grimsby | 26-02-2022 | 16:00 |
| Swindon Town | Salford City | 26-02-2022 | 16:00 |
| Peterborough | Hull City | 26-02-2022 | 16:00 |
| Cheltenham | Crewe | 26-02-2022 | 16:00 |
| King's Lynn Town | Maidenhead | 26-02-2022 | 16:00 |
| Bournemouth | Stoke City | 26-02-2022 | 16:00 |
| Birmingham | Huddersfield | 26-02-2022 | 16:00 |
| Coventry | Preston | 26-02-2022 | 16:00 |
| West Brom | Swansea | 26-02-2022 | 16:00 |
| Bristol Rovers | Exeter City | 26-02-2022 | 16:00 |
| Nottingham Forest | Bristol City | 26-02-2022 | 16:00 |
| Walsall | Hartlepool | 26-02-2022 | 16:00 |
| Burton Albion | Shrewsbury | 26-02-2022 | 16:00 |
| Lincoln | Gillingham | 26-02-2022 | 16:00 |
| Newport County | Tranmere | 26-02-2022 | 16:00 |
| Cardiff | Fulham | 26-02-2022 | 16:00 |
| Chesterfield | Yeovil Town | 26-02-2022 | 16:00 |
| Port Vale | Stevenage | 26-02-2022 | 16:00 |
| Sheffield Wednesday | Charlton | 26-02-2022 | 16:00 |
| Barnsley | Middlesbrough | 26-02-2022 | 16:00 |
| Stockport County | Weymouth | 26-02-2022 | 16:00 |
| Altrincham | Dagenham & Redbridge | 26-02-2022 | 16:00 |
| Wrexham | Aldershot Town | 26-02-2022 | 16:00 |
| Manchester United | Watford | 26-02-2022 | 16:00 |
| FC Halifax Town | Barnet | 26-02-2022 | 16:00 |
| Rochdale | Northampton | 26-02-2022 | 16:00 |
| Bradford | Mansfield Town | 26-02-2022 | 16:00 |
| Wigan | Sunderland | 26-02-2022 | 16:00 |
| Blackburn | QPR | 26-02-2022 | 16:00 |
| Accrington ST | Wycombe | 26-02-2022 | 16:00 |
| Plymouth | Rotherham | 26-02-2022 | 16:00 |
| Blackpool | Reading | 26-02-2022 | 16:00 |
| Morecambe | Ipswich | 26-02-2022 | 16:00 |
| Barrow | Harrogate Town | 26-02-2022 | 16:00 |
| Boreham Wood | Eastleigh | 26-02-2022 | 16:00 |
| Plymouth | Rotherham | 26-02-2022 | 16:00 |
| Stranraer | Albion Rovers | 26-02-2022 | 16:00 |
| Coleraine FC | Ballymena United | 26-02-2022 | 16:00 |
| Newry City AFC | Annagh United | 26-02-2022 | 16:00 |
| Knockbreda | Dundela | 26-02-2022 | 16:00 |
| H&W Welders | Loughgall | 26-02-2022 | 16:00 |
| Cliftonville FC | Crusaders FC | 26-02-2022 | 16:00 |
| Glenavon FC | Glentoran | 26-02-2022 | 16:00 |
| Ayr Utd | Queen of the South | 26-02-2022 | 16:00 |
| Ballyclare Comrades | Queen's University | 26-02-2022 | 16:00 |
| Portadown | Warrenpoint Town | 26-02-2022 | 16:00 |
| Hamilton Academical | Inverness CT | 26-02-2022 | 16:00 |
| Airdrie United | Clyde | 26-02-2022 | 16:00 |
| Raith Rovers | Partick | 26-02-2022 | 16:00 |
| Queen's Park | Montrose | 26-02-2022 | 16:00 |
| Dungannon Swifts | Larne | 26-02-2022 | 16:00 |
| Dunfermline | Kilmarnock | 26-02-2022 | 16:00 |
| Coleraine FC | Ballymena United | 26-02-2022 | 16:00 |
| Newry City AFC | Annagh United | 26-02-2022 | 16:00 |
| Falkirk | East Fife | 26-02-2022 | 16:00 |
| Kelty Hearts | Annan Athletic | 26-02-2022 | 16:00 |
| Stenhousemuir | Forfar Athletic | 26-02-2022 | 16:00 |
| ST Mirren | Heart OF Midlothian | 26-02-2022 | 16:00 |
| Alloa Athletic | Cove Rangers | 26-02-2022 | 16:00 |
| Morton | Arbroath | 26-02-2022 | 16:00 |
| Dundee | Livingston | 26-02-2022 | 16:00 |
| Coleraine FC | Ballymena United | 26-02-2022 | 16:00 |
| Newry City AFC | Annagh United | 26-02-2022 | 16:00 |
| Coleraine FC | Ballymena United | 26-02-2022 | 16:00 |
| Newry City AFC | Annagh United | 26-02-2022 | 16:00 |
| Dergview | Ards | 26-02-2022 | 16:00 |
| Institute | Ballinamallard United | 26-02-2022 | 16:00 |
| Coleraine FC | Ballymena United | 26-02-2022 | 16:00 |
| Newry City AFC | Annagh United | 26-02-2022 | 16:00 |
| Aberdeen | Dundee Utd | 26-02-2022 | 16:00 |
| Peterhead | Dumbarton | 26-02-2022 | 16:00 |
| Elgin City | Stirling Albion | 26-02-2022 | 16:00 |
| Ross County | ST Johnstone | 26-02-2022 | 16:00 |
| Heracles | PEC Zwolle | 26-02-2022 | 16:30 |
| Monterosi | AZ Picerno | 26-02-2022 | 17:30 |
| Foggia | Bari | 26-02-2022 | 17:30 |
| Avellino | Catania | 26-02-2022 | 17:30 |
| Juve Stabia | SS Monopoli | 26-02-2022 | 17:30 |
| Potenza | Paganese | 26-02-2022 | 17:30 |
| Virtus Francavilla | Palermo | 26-02-2022 | 17:30 |
| Vibonese | Messina | 26-02-2022 | 17:30 |
| Catanzaro | Latina | 26-02-2022 | 17:30 |
| Everton | Manchester City | 26-02-2022 | 18:30 |
| Eintracht Frankfurt | Bayern Munich | 26-02-2022 | 18:30 |
| Groningen | Willem II | 26-02-2022 | 18:45 |
| Cambuur | Fortuna Sittard | 26-02-2022 | 21:00 |
| Paris Saint Germain | Saint Etienne | 27-02-2022 | 01:00 |
| Angers | Lens | 27-02-2022 | 01:00 |
| Stade Brestois 29 | Lorient | 27-02-2022 | 01:00 |
| Estac Troyes | Marseille | 27-02-2022 | 01:00 |
| Metz | Nantes | 27-02-2022 | 01:00 |
| Strasbourg | Nice | 27-02-2022 | 01:00 |
| Clermont Foot | Bordeaux | 27-02-2022 | 01:00 |
| Lyon | Lille | 27-02-2022 | 01:00 |
| Torino | Cagliari | 27-02-2022 | 01:00 |
| Real Sociedad | Osasuna | 27-02-2022 | 01:00 |
| Montpellier | Rennes | 27-02-2022 | 01:00 |
| Eibar | Burgos | 27-02-2022 | 01:00 |
| AC Milan | Udinese | 27-02-2022 | 01:00 |
| Atalanta | Sampdoria | 27-02-2022 | 01:00 |
| Dynamo Dresden | SV Darmstadt 98 | 27-02-2022 | 01:00 |
| Sporting Gijon | Zaragoza | 27-02-2022 | 01:00 |
| Oviedo | Real Sociedad II | 27-02-2022 | 01:00 |
| Mirandes | Tenerife | 27-02-2022 | 01:00 |
| Monaco | Reims | 27-02-2022 | 01:00 |
| Genoa | Inter | 27-02-2022 | 01:00 |
| Verona | Venezia | 27-02-2022 | 01:00 |
| Sassuolo | Fiorentina | 27-02-2022 | 01:00 |
| Spezia | AS Roma | 27-02-2022 | 01:00 |
| Barcelona | Athletic Club | 27-02-2022 | 01:00 |
| Valladolid | Amorebieta | 27-02-2022 | 01:00 |
| Empoli | Juventus | 27-02-2022 | 01:00 |
| Chaves | Benfica B | 27-02-2022 | 01:00 |
| Atletico Madrid | Celta Vigo | 27-02-2022 | 01:00 |
| Rayo Vallecano | Real Madrid | 27-02-2022 | 01:00 |
| Leganes | Girona | 27-02-2022 | 01:00 |
| Getafe | Alaves | 27-02-2022 | 01:00 |
| SC Braga | Santa Clara | 27-02-2022 | 01:00 |
| Alcorcon | Ponferradina | 27-02-2022 | 01:00 |
| Villarreal | Espanyol | 27-02-2022 | 01:00 |
| Vizela | Portimonense | 27-02-2022 | 01:00 |
| Famalicao | Tondela | 27-02-2022 | 01:00 |
| Varzim | Feirense | 27-02-2022 | 01:00 |
| Rio Ave | FC Porto B | 27-02-2022 | 01:00 |
| FC Porto | GIL Vicente | 27-02-2022 | 01:00 |
| Leixoes | Estrela | 27-02-2022 | 01:00 |
| Arouca | Moreirense | 27-02-2022 | 01:00 |
| Levante | Elche | 27-02-2022 | 01:00 |
| Mallorca | Valencia | 27-02-2022 | 01:00 |
| SC Covilha | Casa Pia | 27-02-2022 | 01:00 |
| Ibiza | Huesca | 27-02-2022 | 01:00 |
| Academica | Academico Viseu | 27-02-2022 | 01:00 |
| Lazio | Napoli | 27-02-2022 | 01:00 |
| Mafra | Penafiel | 27-02-2022 | 01:00 |
| Belenenses | Pacos Ferreira | 27-02-2022 | 01:00 |
| Estoril | Boavista | 27-02-2022 | 01:00 |
| Granada CF | Cadiz | 27-02-2022 | 01:00 |
| Sevilla | Real Betis | 27-02-2022 | 01:00 |
| Almeria | Fuenlabrada | 27-02-2022 | 01:00 |
| Salernitana | Bologna | 27-02-2022 | 01:00 |
| Malaga | FC Cartagena | 27-02-2022 | 01:00 |
| Fidelis Andria | Taranto | 27-02-2022 | 01:00 |
| Farense | Vilafranquense | 27-02-2022 | 01:00 |
| Istanbul Basaksehir | Fatih Karagümrük | 27-02-2022 | 01:00 |
| Galatasaray | Rizespor | 27-02-2022 | 01:00 |
| Nacional | Trofense | 27-02-2022 | 01:00 |
| Kasimpasa | Fenerbahce | 27-02-2022 | 01:00 |
| Maritimo | Sporting CP | 27-02-2022 | 01:00 |
| Menemen Belediyespor | Alt?nordu | 27-02-2022 | 01:00 |
| Altay | Gazi?ehir Gaziantep | 27-02-2022 | 01:00 |
| Manisa BBSK | Eyüpspor | 27-02-2022 | 01:00 |
| Denizlispor | Boluspor | 27-02-2022 | 01:00 |
| Genclerbirligi | Bal?kesirspor | 27-02-2022 | 01:00 |
| Las Palmas | Lugo | 27-02-2022 | 01:00 |
| Alanyaspor | Konyaspor | 27-02-2022 | 01:00 |
| Sivasspor | Besiktas | 27-02-2022 | 01:00 |
| Giresunspor | Goztepe | 27-02-2022 | 01:00 |
| Adana Demirspor | Antalyaspor | 27-02-2022 | 01:00 |
| Hatayspor | Yeni Malatyaspor | 27-02-2022 | 01:00 |
| Erzurum BB | Ankaragucu | 27-02-2022 | 01:00 |
| AZ Alkmaar | Feyenoord | 27-02-2022 | 12:15 |
| Vitesse | NEC Nijmegen | 27-02-2022 | 12:15 |
| Hibernian | Celtic | 27-02-2022 | 13:00 |
| Hamburger SV | Werder Bremen | 27-02-2022 | 13:30 |
| FC Heidenheim | SV Sandhausen | 27-02-2022 | 13:30 |
| Jahn Regensburg | Fortuna Dusseldorf | 27-02-2022 | 13:30 |
| Sparta Rotterdam | PSV Eindhoven | 27-02-2022 | 14:30 |
| Modena | Pescara | 27-02-2022 | 14:30 |
| Carrarese | Gubbio | 27-02-2022 | 14:30 |
| Lucchese | Fermana | 27-02-2022 | 14:30 |
| Pistoiese | Imolese | 27-02-2022 | 14:30 |
| Pontedera | Cesena | 27-02-2022 | 14:30 |
| Robur Siena | Viterbese | 27-02-2022 | 14:30 |
| Vis Pesaro | Virtus Entella | 27-02-2022 | 14:30 |
| Ancona | Reggiana | 27-02-2022 | 14:30 |
| Olbia | Montevarchi Calcio | 27-02-2022 | 14:30 |
| Teramo | Grosseto | 27-02-2022 | 14:30 |
| Chelsea | Leicester | 27-02-2022 | 15:00 |
| VfL BOCHUM | RB Leipzig | 27-02-2022 | 15:30 |
| Rangers | Motherwell | 27-02-2022 | 16:00 |
| GO Ahead Eagles | Ajax | 27-02-2022 | 16:45 |
| FC Augsburg | Borussia Dortmund | 27-02-2022 | 17:30 |
| Giana Erminio | PRO Vercelli | 27-02-2022 | 17:30 |
| Giana Erminio | PRO Vercelli | 27-02-2022 | 17:30 |
| Pro Patria | Legnago Salus | 27-02-2022 | 17:30 |
| Renate | Lecco | 27-02-2022 | 17:30 |
| Giana Erminio | PRO Vercelli | 27-02-2022 | 17:30 |
| Juventus U23 | Albinoleffe | 27-02-2022 | 17:30 |
| Giana Erminio | PRO Vercelli | 27-02-2022 | 17:30 |
| Pergolettese | Fiorenzuola | 27-02-2022 | 17:30 |
| Giana Erminio | PRO Vercelli | 27-02-2022 | 17:30 |
| Feralpisalo | Trento | 27-02-2022 | 17:30 |
| Piacenza | Sudtirol | 27-02-2022 | 17:30 |
| Giana Erminio | PRO Vercelli | 27-02-2022 | 17:30 |
| Giana Erminio | PRO Vercelli | 27-02-2022 | 17:30 |
| Virtus Verona | Seregno | 27-02-2022 | 17:30 |
| Mantova | Triestina | 27-02-2022 | 17:30 |
| Padova | Pro Sesto | 27-02-2022 | 17:30 |
| Giana Erminio | PRO Vercelli | 27-02-2022 | 17:30 |
| Giana Erminio | PRO Vercelli | 27-02-2022 | 17:30 |
| Giana Erminio | PRO Vercelli | 27-02-2022 | 17:30 |
| Heerenveen | Utrecht | 27-02-2022 | 20:00 |
| Club Brugge KV | Gent | 01-03-2022 | 01:00 |
| Anderlecht | AS Eupen | 01-03-2022 | 01:00 |
| Monza | Parma | 01-03-2022 | 15:00 |
| Alessandria | como | 01-03-2022 | 15:00 |
| Brescia | Perugia | 01-03-2022 | 15:00 |
| Spal | Cittadella | 01-03-2022 | 15:00 |
| Pisa | Crotone | 01-03-2022 | 15:00 |
| Ternana | Pordenone | 01-03-2022 | 15:00 |
| Frosinone | Nuova Cosenza | 01-03-2022 | 15:00 |
| Benevento | Cremonese | 01-03-2022 | 15:00 |
| Lecce | Ascoli | 01-03-2022 | 15:00 |
| Reggina | Vicenza Virtus | 01-03-2022 | 15:00 |
| Crawley Town | Oldham | 01-03-2022 | 20:45 |
| Wycombe | Cambridge United | 01-03-2022 | 20:45 |
| Colchester | Leyton Orient | 01-03-2022 | 20:45 |
| Bristol Rovers | Barrow | 01-03-2022 | 20:45 |
| Newport County | Forest Green | 01-03-2022 | 20:45 |
| Chesterfield | Notts County | 01-03-2022 | 20:45 |
| Shrewsbury | Rotherham | 01-03-2022 | 20:45 |
| Sheffield Wednesday | Burton Albion | 01-03-2022 | 20:45 |
| Celtic | ST Mirren | 02-03-2022 | 20:45 |
| Heart OF Midlothian | Aberdeen | 02-03-2022 | 20:45 |
| Livingston | Dundee Utd | 02-03-2022 | 20:45 |
| Motherwell | Ross County | 02-03-2022 | 20:45 |
| Celtic | ST Mirren | 02-03-2022 | 20:45 |
| Dundee | Hibernian | 02-03-2022 | 20:45 |
| ST Johnstone | Rangers | 02-03-2022 | 20:45 |
| Boulogne | Avranches | 04-03-2022 | 01:00 |
| Royal Excel Mouscron | RWDM | 04-03-2022 | 01:00 |
| Deinze | KVC Westerlo | 04-03-2022 | 01:00 |
| Waasland-beveren | Excelsior Virton | 04-03-2022 | 01:00 |
| Chambly Thelle FC | Cholet | 04-03-2022 | 01:00 |
| Lierse Kempenzonen | Lommel United | 04-03-2022 | 01:00 |
| RED Star FC 93 | Bastia-Borgo | 04-03-2022 | 01:00 |
| Laval | Creteil | 04-03-2022 | 01:00 |
| Sedan | Chateauroux | 04-03-2022 | 01:00 |
| Orleans | Villefranche | 04-03-2022 | 01:00 |
| MSV Duisburg | FC Viktoria Koln | 04-03-2022 | 01:00 |
| Concarneau | Le Mans | 04-03-2022 | 01:00 |
| Borussia Dortmund II | Türkgücü-Ataspor | 04-03-2022 | 01:00 |
| FC Saarbrucken | SV Meppen | 04-03-2022 | 01:00 |
| VfL Osnabruck | FC Kaiserslautern | 04-03-2022 | 01:00 |
| SV Wehen | FC Wurzburger Kickers | 04-03-2022 | 01:00 |
| Annecy | Stade Briochin | 04-03-2022 | 01:00 |
| Waldhof Mannheim | Eintracht Braunschweig | 04-03-2022 | 01:00 |
| Havelse | Viktoria Berlin | 04-03-2022 | 01:00 |
| Freiburg II | FSV Zwickau | 04-03-2022 | 01:00 |
| Bourg-en-bresse 01 | Sète | 04-03-2022 | 01:00 |
| Annecy | Stade Briochin | 04-03-2022 | 01:00 |
| FC Magdeburg | Hallescher FC | 04-03-2022 | 01:00 |
| TSV 1860 Munich | Verl | 04-03-2022 | 01:00 |
| Annecy | Stade Briochin | 04-03-2022 | 01:00 |
| SV Darmstadt 98 | FC Heidenheim | 04-03-2022 | 18:30 |
| Holstein Kiel | SC Paderborn 07 | 04-03-2022 | 18:30 |
| Excelsior | Den Bosch | 04-03-2022 | 20:00 |
| Telstar | FC OSS | 04-03-2022 | 20:00 |
| Helmond Sport | FC Eindhoven | 04-03-2022 | 20:00 |
| MVV | NAC Breda | 04-03-2022 | 20:00 |
| Vitesse | Sparta Rotterdam | 04-03-2022 | 20:00 |
| Roda | Dordrecht | 04-03-2022 | 20:00 |
| VVV Venlo | FC Volendam | 04-03-2022 | 20:00 |
| De Graafschap | Jong AZ | 04-03-2022 | 20:00 |
| Roda | Dordrecht | 04-03-2022 | 20:00 |
| Taffs Well | Pontypridd Town | 04-03-2022 | 20:30 |
| Briton Ferry | Ammanford AFC | 04-03-2022 | 20:30 |
| llanelli AFC | Risca United | 04-03-2022 | 20:30 |
| Holyhead Hotspur | Conwy Borough | 04-03-2022 | 20:30 |
| Arminia Bielefeld | FC Augsburg | 04-03-2022 | 20:30 |
| Cercle Brugge | Genk | 05-03-2022 | 01:00 |
| Kortrijk | Union St. Gilloise | 05-03-2022 | 01:00 |
| Quevilly | LE Havre | 05-03-2022 | 01:00 |
| Gent | Zulte Waregem | 05-03-2022 | 01:00 |
| Anderlecht | Oostende | 05-03-2022 | 01:00 |
| Antwerp | Beerschot Wilrijk | 05-03-2022 | 01:00 |
| Charleroi | Standard Liege | 05-03-2022 | 01:00 |
| St. Truiden | KV Mechelen | 05-03-2022 | 01:00 |
| Seraing United | Club Brugge KV | 05-03-2022 | 01:00 |
| AS Eupen | OH Leuven | 05-03-2022 | 01:00 |
| Nancy | Grenoble | 05-03-2022 | 01:00 |
| Niort | Ajaccio | 05-03-2022 | 01:00 |
| Dijon | Caen | 05-03-2022 | 01:00 |
| Sochaux | Guingamp | 05-03-2022 | 01:00 |
| Rodez | Auxerre | 05-03-2022 | 01:00 |
| Toulouse | Dunkerque | 05-03-2022 | 01:00 |
| PAU | Amiens | 05-03-2022 | 01:00 |
| Nimes | Paris FC | 05-03-2022 | 01:00 |
| Bastia | Valenciennes | 05-03-2022 | 01:00 |
| Harrogate Town | Hartlepool | 05-03-2022 | 13:30 |
| GVVV Veenendaal | Noordwijk | 05-03-2022 | 14:30 |
| Undy Athletic | Trefelin | 05-03-2022 | 15:00 |
| Undy Athletic | Trefelin | 05-03-2022 | 15:00 |
| Llantwit Major | Carmarthen Town | 05-03-2022 | 15:00 |
| Quick Boys | Ijsselmeervogels | 05-03-2022 | 15:00 |
| Rijnsburgse Boys | HHC | 05-03-2022 | 15:00 |
| Kozakken Boys | Excelsior Maassluis | 05-03-2022 | 15:00 |
| Spakenburg | ASWH | 05-03-2022 | 15:00 |
| como | Spal | 05-03-2022 | 15:00 |
| Cremonese | Brescia | 05-03-2022 | 15:00 |
| Parma | Reggina | 05-03-2022 | 15:00 |
| Vicenza Virtus | Ternana | 05-03-2022 | 15:00 |
| Cittadella | Monza | 05-03-2022 | 15:00 |
| Pordenone | Pisa | 05-03-2022 | 15:00 |
| Perugia | Lecce | 05-03-2022 | 15:00 |
| Ascoli | Frosinone | 05-03-2022 | 15:00 |
| Nuova Cosenza | Benevento | 05-03-2022 | 15:00 |
| Crotone | Alessandria | 05-03-2022 | 15:00 |
| Cwmbran Celtic | Goytre United | 05-03-2022 | 15:30 |
| Port Talbot Town | Cambrian & Clydach | 05-03-2022 | 15:30 |
| Llanidloes Town | Llandudno | 05-03-2022 | 15:30 |
| Llanrhaeadr | Ruthin Town | 05-03-2022 | 15:30 |
| Swansea University | Afan Lido | 05-03-2022 | 15:30 |
| Buckley Town | Prestatyn Town | 05-03-2022 | 15:30 |
| Penrhyncoch | Guilsfield | 05-03-2022 | 15:30 |
| Llanidloes Town | Llandudno | 05-03-2022 | 15:30 |
| Colwyn Bay | Airbus UK | 05-03-2022 | 15:30 |
| Sparta Rotterdam II | Katwijk | 05-03-2022 | 15:30 |
| Bangor City | Holywell | 05-03-2022 | 15:30 |
| Llangefni Town | Gresford Athletic | 05-03-2022 | 15:30 |
| Llanidloes Town | Llandudno | 05-03-2022 | 15:30 |
| Volendam II | AFC Amsterdam | 05-03-2022 | 15:30 |
| Llanidloes Town | Llandudno | 05-03-2022 | 15:30 |
| VfL BOCHUM | SpVgg Greuther Furth | 05-03-2022 | 15:30 |
| Cwmbran Celtic | Goytre United | 05-03-2022 | 15:30 |
| Llanidloes Town | Llandudno | 05-03-2022 | 15:30 |
| VfL Wolfsburg | Union Berlin | 05-03-2022 | 15:30 |
| RB Leipzig | SC Freiburg | 05-03-2022 | 15:30 |
| Bayern Munich | Bayer Leverkusen | 05-03-2022 | 15:30 |
| Hertha Berlin | Eintracht Frankfurt | 05-03-2022 | 15:30 |
| RB Leipzig | SC Freiburg | 05-03-2022 | 15:30 |
| Fulham | Blackburn | 05-03-2022 | 16:00 |
| QPR | Cardiff | 05-03-2022 | 16:00 |
| Leyton Orient | Stevenage | 05-03-2022 | 16:00 |
| Tottenham | Everton | 05-03-2022 | 16:00 |
| Charlton | Sunderland | 05-03-2022 | 16:00 |
| Barnet | Dover | 05-03-2022 | 16:00 |
| Sutton Utd | Rochdale | 05-03-2022 | 16:00 |
| Dagenham & Redbridge | Boreham Wood | 05-03-2022 | 16:00 |
| Watford | Arsenal | 05-03-2022 | 16:00 |
| Maidenhead | Altrincham | 05-03-2022 | 16:00 |
| Crawley Town | Scunthorpe | 05-03-2022 | 16:00 |
| Gillingham | Bolton | 05-03-2022 | 16:00 |
| Aldershot Town | Stockport County | 05-03-2022 | 16:00 |
| Reading | Millwall | 05-03-2022 | 16:00 |
| Oxford United | Burton Albion | 05-03-2022 | 16:00 |
| Cambridge United | Shrewsbury | 05-03-2022 | 16:00 |
| Colchester | Port Vale | 05-03-2022 | 16:00 |
| Newcastle | Brighton | 05-03-2022 | 16:00 |
| Northampton | Tranmere | 05-03-2022 | 16:00 |
| Portsmouth | Accrington ST | 05-03-2022 | 16:00 |
| Eastleigh | Wealdstone | 05-03-2022 | 16:00 |
| Cheltenham | Doncaster | 05-03-2022 | 16:00 |
| Leicester | Leeds | 05-03-2022 | 16:00 |
| Solihull Moors | King's Lynn Town | 05-03-2022 | 16:00 |
| Norwich | Brentford | 05-03-2022 | 16:00 |
| Aston Villa | Southampton | 05-03-2022 | 16:00 |
| Bristol City | Birmingham | 05-03-2022 | 16:00 |
| Notts County | Yeovil Town | 05-03-2022 | 16:00 |
| Derby | Barnsley | 05-03-2022 | 16:00 |
| Wolves | Crystal Palace | 05-03-2022 | 16:00 |
| Lincoln | Sheffield Wednesday | 05-03-2022 | 16:00 |
| Weymouth | FC Halifax Town | 05-03-2022 | 16:00 |
| Mansfield Town | Exeter City | 05-03-2022 | 16:00 |
| Newport County | Bristol Rovers | 05-03-2022 | 16:00 |
| Chesterfield | Southend | 05-03-2022 | 16:00 |
| Stoke City | Blackpool | 05-03-2022 | 16:00 |
| Sheffield Utd | Nottingham Forest | 05-03-2022 | 16:00 |
| Rotherham | Milton Keynes Dons | 05-03-2022 | 16:00 |
| Grimsby | Woking | 05-03-2022 | 16:00 |
| Crewe | Wycombe | 05-03-2022 | 16:00 |
| Hull City | West Brom | 05-03-2022 | 16:00 |
| Manchester City | Manchester United | 05-03-2022 | 16:00 |
| Swansea | Coventry | 05-03-2022 | 16:00 |
| Huddersfield | Peterborough | 05-03-2022 | 16:00 |
| Torquay | Bromley | 05-03-2022 | 16:00 |
| Oldham | Carlisle | 05-03-2022 | 16:00 |
| Salford City | Forest Green | 05-03-2022 | 16:00 |
| Bradford | Swindon Town | 05-03-2022 | 16:00 |
| Watford | Arsenal | 05-03-2022 | 16:00 |
| Wigan | AFC Wimbledon | 05-03-2022 | 16:00 |
| Liverpool | West Ham | 05-03-2022 | 16:00 |
| Cowdenbeath | Kelty Hearts | 05-03-2022 | 16:00 |
| Burnley | Chelsea | 05-03-2022 | 16:00 |
| Preston | Bournemouth | 05-03-2022 | 16:00 |
| Plymouth | Morecambe | 05-03-2022 | 16:00 |
| Fleetwood Town | Ipswich | 05-03-2022 | 16:00 |
| Middlesbrough | Luton | 05-03-2022 | 16:00 |
| Barrow | Walsall | 05-03-2022 | 16:00 |
| Newcastle | Brighton | 05-03-2022 | 16:00 |
| Annan Athletic | Stranraer | 05-03-2022 | 16:00 |
| Queen of the South | Morton | 05-03-2022 | 16:00 |
| Plymouth | Morecambe | 05-03-2022 | 16:00 |
| Ards | Ballyclare Comrades | 05-03-2022 | 16:00 |
| Dundela | Institute | 05-03-2022 | 16:00 |
| Queen's University | Annagh United | 05-03-2022 | 16:00 |
| Hibernian | ST Johnstone | 05-03-2022 | 16:00 |
| Livingston | Celtic | 05-03-2022 | 16:00 |
| Motherwell | Dundee | 05-03-2022 | 16:00 |
| Kilmarnock | Hamilton Academical | 05-03-2022 | 16:00 |
| Loughgall | Newry City AFC | 05-03-2022 | 16:00 |
| Albion Rovers | Edinburgh City | 05-03-2022 | 16:00 |
| Raith Rovers | Ayr Utd | 05-03-2022 | 16:00 |
| Cowdenbeath | Kelty Hearts | 05-03-2022 | 16:00 |
| Rangers | Aberdeen | 05-03-2022 | 16:00 |
| Clyde | Falkirk | 05-03-2022 | 16:00 |
| Partick | Inverness CT | 05-03-2022 | 16:00 |
| Alloa Athletic | Airdrie United | 05-03-2022 | 16:00 |
| Stirling Albion | Stenhousemuir | 05-03-2022 | 16:00 |
| Dumbarton | Queen's Park | 05-03-2022 | 16:00 |
| Dundee Utd | Heart OF Midlothian | 05-03-2022 | 16:00 |
| Arbroath | Dunfermline | 05-03-2022 | 16:00 |
| Middlesbrough | Luton | 05-03-2022 | 16:00 |
| Ballinamallard United | H&W Welders | 05-03-2022 | 16:00 |
| Montrose | East Fife | 05-03-2022 | 16:00 |
| Forfar Athletic | Elgin City | 05-03-2022 | 16:00 |
| Dergview | Knockbreda | 05-03-2022 | 16:00 |
| Cove Rangers | Peterhead | 05-03-2022 | 16:00 |
| Forfar Athletic | Elgin City | 05-03-2022 | 16:00 |
| Ross County | ST Mirren | 05-03-2022 | 16:00 |
| Wolves | Crystal Palace | 05-03-2022 | 16:00 |
| PSV Eindhoven | Heracles | 05-03-2022 | 16:30 |
| VfB Stuttgart | Borussia Monchengladbach | 05-03-2022 | 18:30 |
| GO Ahead Eagles | Utrecht | 05-03-2022 | 20:00 |
| Feyenoord | Groningen | 05-03-2022 | 21:00 |
| Lens | Stade Brestois 29 | 06-03-2022 | 01:00 |
| Lille | Clermont Foot | 06-03-2022 | 01:00 |
| Lille | Clermont Foot | 06-03-2022 | 01:00 |
| Reims | Strasbourg | 06-03-2022 | 01:00 |
| Rennes | Angers | 06-03-2022 | 01:00 |
| NEC Nijmegen | AZ Alkmaar | 06-03-2022 | 01:00 |
| Lorient | Lyon | 06-03-2022 | 01:00 |
| Nantes | Montpellier | 06-03-2022 | 01:00 |
| FC Schalke 04 | Hansa Rostock | 06-03-2022 | 01:00 |
| SV Sandhausen | Hannover 96 | 06-03-2022 | 01:00 |
| FC St. Pauli | Karlsruher SC | 06-03-2022 | 01:00 |
| Bordeaux | Estac Troyes | 06-03-2022 | 01:00 |
| Saint Etienne | Metz | 06-03-2022 | 01:00 |
| FC Nurnberg | Hamburger SV | 06-03-2022 | 01:00 |
| Giana Erminio | Piacenza | 06-03-2022 | 01:00 |
| Fiorenzuola | Virtus Verona | 06-03-2022 | 01:00 |
| Giana Erminio | Piacenza | 06-03-2022 | 01:00 |
| Fiorenzuola | Virtus Verona | 06-03-2022 | 01:00 |
| Juventus | Spezia | 06-03-2022 | 01:00 |
| Real Sociedad II | Sporting Gijon | 06-03-2022 | 01:00 |
| PRO Vercelli | Pro Patria | 06-03-2022 | 01:00 |
| Lecco | Pergolettese | 06-03-2022 | 01:00 |
| Athletic Club | Levante | 06-03-2022 | 01:00 |
| Amorebieta | Malaga | 06-03-2022 | 01:00 |
| Seregno | Albinoleffe | 06-03-2022 | 01:00 |
| Inter | Salernitana | 06-03-2022 | 01:00 |
| Pro Sesto | Juventus U23 | 06-03-2022 | 01:00 |
| Giana Erminio | Piacenza | 06-03-2022 | 01:00 |
| Fiorenzuola | Virtus Verona | 06-03-2022 | 01:00 |
| Osasuna | Villarreal | 06-03-2022 | 01:00 |
| Giana Erminio | Piacenza | 06-03-2022 | 01:00 |
| Fiorenzuola | Virtus Verona | 06-03-2022 | 01:00 |
| Alaves | Sevilla | 06-03-2022 | 01:00 |
| Sudtirol | Mantova | 06-03-2022 | 01:00 |
| Marseille | Monaco | 06-03-2022 | 01:00 |
| Giana Erminio | Piacenza | 06-03-2022 | 01:00 |
| Fiorenzuola | Virtus Verona | 06-03-2022 | 01:00 |
| Nice | Paris Saint Germain | 06-03-2022 | 01:00 |
| Giana Erminio | Piacenza | 06-03-2022 | 01:00 |
| Fiorenzuola | Virtus Verona | 06-03-2022 | 01:00 |
| Genoa | Empoli | 06-03-2022 | 01:00 |
| Giana Erminio | Piacenza | 06-03-2022 | 01:00 |
| Fiorenzuola | Virtus Verona | 06-03-2022 | 01:00 |
| Huesca | Las Palmas | 06-03-2022 | 01:00 |
| Virtus Entella | Carrarese | 06-03-2022 | 01:00 |
| Girona | Oviedo | 06-03-2022 | 01:00 |
| Lugo | Alcorcon | 06-03-2022 | 01:00 |
| Reggiana | Pontedera | 06-03-2022 | 01:00 |
| Zaragoza | Almeria | 06-03-2022 | 01:00 |
| Ponferradina | Ibiza | 06-03-2022 | 01:00 |
| Padova | Feralpisalo | 06-03-2022 | 01:00 |
| Modena | Olbia | 06-03-2022 | 01:00 |
| Venezia | Sassuolo | 06-03-2022 | 01:00 |
| Espanyol | Getafe | 06-03-2022 | 01:00 |
| Udinese | Sampdoria | 06-03-2022 | 01:00 |
| Bologna | Torino | 06-03-2022 | 01:00 |
| Giana Erminio | Piacenza | 06-03-2022 | 01:00 |
| Fiorenzuola | Virtus Verona | 06-03-2022 | 01:00 |
| Fiorentina | Verona | 06-03-2022 | 01:00 |
| Triestina | Renate | 06-03-2022 | 01:00 |
| Celta Vigo | Mallorca | 06-03-2022 | 01:00 |
| Cesena | Teramo | 06-03-2022 | 01:00 |
| Montevarchi Calcio | Pistoiese | 06-03-2022 | 01:00 |
| Real Madrid | Real Sociedad | 06-03-2022 | 01:00 |
| Leganes | Mirandes | 06-03-2022 | 01:00 |
| Fuenlabrada | Burgos | 06-03-2022 | 01:00 |
| Guimaraes | Famalicao | 06-03-2022 | 01:00 |
| GIL Vicente | Estoril | 06-03-2022 | 01:00 |
| Moreirense | Maritimo | 06-03-2022 | 01:00 |
| Grosseto | Imolese | 06-03-2022 | 01:00 |
| Pacos Ferreira | FC Porto | 06-03-2022 | 01:00 |
| Trofense | Farense | 06-03-2022 | 01:00 |
| Penafiel | Chaves | 06-03-2022 | 01:00 |
| Gubbio | Vis Pesaro | 06-03-2022 | 01:00 |
| Santa Clara | Vizela | 06-03-2022 | 01:00 |
| Boavista | SC Braga | 06-03-2022 | 01:00 |
| FC Porto B | Academica | 06-03-2022 | 01:00 |
| Giana Erminio | Piacenza | 06-03-2022 | 01:00 |
| Fiorenzuola | Virtus Verona | 06-03-2022 | 01:00 |
| Valencia | Granada CF | 06-03-2022 | 01:00 |
| Feirense | Leixoes | 06-03-2022 | 01:00 |
| Academico Viseu | Estrela | 06-03-2022 | 01:00 |
| Tondela | Belenenses | 06-03-2022 | 01:00 |
| Viterbese | Lucchese | 06-03-2022 | 01:00 |
| Fermana | Ancona | 06-03-2022 | 01:00 |
| AS Roma | Atalanta | 06-03-2022 | 01:00 |
| Giana Erminio | Piacenza | 06-03-2022 | 01:00 |
| Fiorenzuola | Virtus Verona | 06-03-2022 | 01:00 |
| Elche | Barcelona | 06-03-2022 | 01:00 |
| Pescara | Robur Siena | 06-03-2022 | 01:00 |
| Latina | Potenza | 06-03-2022 | 01:00 |
| Vilafranquense | Rio Ave | 06-03-2022 | 01:00 |
| Cagliari | Lazio | 06-03-2022 | 01:00 |
| FC Cartagena | Eibar | 06-03-2022 | 01:00 |
| Sporting CP | Arouca | 06-03-2022 | 01:00 |
| Casa Pia | Mafra | 06-03-2022 | 01:00 |
| Benfica B | Varzim | 06-03-2022 | 01:00 |
| Napoli | AC Milan | 06-03-2022 | 01:00 |
| Turris | Fidelis Andria | 06-03-2022 | 01:00 |
| Real Betis | Atletico Madrid | 06-03-2022 | 01:00 |
| Paganese | Avellino | 06-03-2022 | 01:00 |
| Penafiel | Chaves | 06-03-2022 | 01:00 |
| AZ Picerno | Città di Campobasso | 06-03-2022 | 01:00 |
| Portimonense | Benfica | 06-03-2022 | 01:00 |
| Bari | Virtus Francavilla | 06-03-2022 | 01:00 |
| Cadiz | Rayo Vallecano | 06-03-2022 | 01:00 |
| SS Monopoli | Catanzaro | 06-03-2022 | 01:00 |
| Taranto | Foggia | 06-03-2022 | 01:00 |
| Palermo | Vibonese | 06-03-2022 | 01:00 |
| Messina | Juve Stabia | 06-03-2022 | 01:00 |
| Catania | Monterosi | 06-03-2022 | 01:00 |
| Nacional | SC Covilha | 06-03-2022 | 01:00 |
| Besiktas | Istanbul Basaksehir | 06-03-2022 | 01:00 |
| Fenerbahce | Trabzonspor | 06-03-2022 | 01:00 |
| Santa Clara | Vizela | 06-03-2022 | 01:00 |
| Tuzlaspor | ?stanbulspor | 06-03-2022 | 01:00 |
| Goztepe | Kasimpasa | 06-03-2022 | 01:00 |
| Kocaelispor | Keçiörengücü | 06-03-2022 | 01:00 |
| Boluspor | Bursaspor | 06-03-2022 | 01:00 |
| Ankaragucu | Band?rmaspor | 06-03-2022 | 01:00 |
| Tenerife | Valladolid | 06-03-2022 | 01:00 |
| Antalyaspor | Sivasspor | 06-03-2022 | 01:00 |
| Konyaspor | Galatasaray | 06-03-2022 | 01:00 |
| Samsunspor | Menemen Belediyespor | 06-03-2022 | 01:00 |
| Kayserispor | Alanyaspor | 06-03-2022 | 01:00 |
| Adanaspor | Manisa BBSK | 06-03-2022 | 01:00 |
| Rizespor | Giresunspor | 06-03-2022 | 01:00 |
| Yeni Malatyaspor | Adana Demirspor | 06-03-2022 | 01:00 |
| Willem II | Heerenveen | 06-03-2022 | 12:15 |
| Fortuna Dusseldorf | FC Ingolstadt 04 | 06-03-2022 | 13:30 |
| Werder Bremen | Dynamo Dresden | 06-03-2022 | 13:30 |
| Erzgebirge AUE | Jahn Regensburg | 06-03-2022 | 13:30 |
| De Treffers | TEC | 06-03-2022 | 14:30 |
| De Treffers | TEC | 06-03-2022 | 14:30 |
| Twente | Cambuur | 06-03-2022 | 14:30 |
| FSV Mainz 05 | Borussia Dortmund | 06-03-2022 | 15:30 |
| Ajax | Waalwijk | 06-03-2022 | 16:45 |